{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239641330432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3762/bjnano.5.238"}},{"identifier":{"@type":"URI","@value":"https://www.beilstein-journals.org/bjnano/articles/5/238"}},{"identifier":{"@type":"URI","@value":"https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-5-238.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.beilstein-journals.org/bjnano/content/5/1/238"}},{"identifier":{"@type":"PMID","@value":"25551057"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The anticancer efficacy of a supramolecular complex that was used as an artificial enzyme against multi-drug-resistant cancer cells was confirmed. A complex of diethylaminoethyl–dextran–methacrylic acid methylester copolymer (DDMC)/paclitaxel (PTX), obtained with PTX as the guest and DDMC as the host, formed a nanoparticle 50–300 nm in size. This complex is considered to be useful as a drug delivery system (DDS) for anticancer compounds since it formed a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to PTX was shown clearly through a maximum survival curve. Conversely, the DDMC/PTX complex showed a superior anticancer efficacy and cell killing rate, as determined through a Michaelis–Menten-type equation, which may promote an allosteric supramolecular reaction to tubulin, in the same manner as an enzymatic reaction. The DDMC/PTX complex showed significantly higher anticancer activity compared to PTX alone in mouse skin in vivo. The median survival times of the saline, PTX, DDMC/PTX4 (particle size 50 nm), and DDMC/PTX5 (particle size 290 nm) groups were 120 h (treatment (T)/control (C), 1.0), 176 h (T/C, 1.46), 328 h (T/C, 2.73), and 280 h (T/C, 2.33), respectively. The supramolecular DDMC/PTX complex showed twice the effectiveness of PTX alone (<jats:italic>p</jats:italic>< 0.036). Above all, the DDMC/PTX complex is not degraded in cells and acts as an intact supramolecular assembly, which adds a new species to the range of DDS.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239641330304","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Onishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330305","@type":"Researcher","foaf:name":[{"@value":"Yuki Eshita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330434","@type":"Researcher","foaf:name":[{"@value":"Rui-Cheng Ji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330307","@type":"Researcher","foaf:name":[{"@value":"Masayasu Onishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276161733248","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30380520"},{"@type":"NRID","@value":"1000030380520"},{"@type":"NRID","@value":"9000000782222"},{"@type":"NRID","@value":"9000362188611"},{"@type":"NRID","@value":"9000002042473"},{"@type":"NRID","@value":"9000406358147"},{"@type":"NRID","@value":"9000017587529"},{"@type":"NRID","@value":"9000018375240"},{"@type":"NRID","@value":"9000006477608"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0118220"}],"foaf:name":[{"@value":"Takashi Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330432","@type":"Researcher","foaf:name":[{"@value":"Masaaki Mizuno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330306","@type":"Researcher","foaf:name":[{"@value":"Jun Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239641330309","@type":"Researcher","foaf:name":[{"@value":"Naoji Kubota"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"21904286"}],"prism:publicationName":[{"@value":"Beilstein Journal of Nanotechnology"}],"dc:publisher":[{"@value":"Beilstein Institut"}],"prism:publicationDate":"2014-12-01","prism:volume":"5","prism:startingPage":"2293","prism:endingPage":"2307"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/2.0","http://creativecommons.org/licenses/by/2.0","http://creativecommons.org/licenses/by/2.0"],"url":[{"@id":"https://www.beilstein-journals.org/bjnano/articles/5/238"},{"@id":"https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-5-238.pdf"},{"@id":"http://www.beilstein-journals.org/bjnano/content/5/1/238"}],"createdAt":"2014-12-01","modifiedAt":"2022-04-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=diethylaminoethyl%E2%80%93dextran%E2%80%93MMA","dc:title":"diethylaminoethyl–dextran–MMA"},{"@id":"https://cir.nii.ac.jp/all?q=artificial%20enzyme","dc:title":"artificial enzyme"},{"@id":"https://cir.nii.ac.jp/all?q=Technology","dc:title":"Technology"},{"@id":"https://cir.nii.ac.jp/all?q=T","dc:title":"T"},{"@id":"https://cir.nii.ac.jp/all?q=Chemical%20technology","dc:title":"Chemical technology"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Physics","dc:title":"Physics"},{"@id":"https://cir.nii.ac.jp/all?q=QC1-999","dc:title":"QC1-999"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=TP1-1185","dc:title":"TP1-1185"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=paclitaxel","dc:title":"paclitaxel"},{"@id":"https://cir.nii.ac.jp/all?q=multi-drug%20resistance%20of%20cancer%20cells","dc:title":"multi-drug resistance of cancer cells"},{"@id":"https://cir.nii.ac.jp/all?q=supramolecular%20complex","dc:title":"supramolecular complex"},{"@id":"https://cir.nii.ac.jp/all?q=graft%20copolymer","dc:title":"graft copolymer"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782290656000","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26305014"},{"@type":"JGN","@value":"JP26305014"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26305014/"}],"notation":[{"@language":"ja","@value":"バングラデシュにおけるポスト・カラ・アザール皮膚リーシュマニア症の発症機序の解明"},{"@language":"en","@value":"Analysis of pathogenic factor in the onset mechanism of Post-kala-azar dermal leishmaniasis (PKDL) in Bangladesh"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220971967360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism of the Introduction of Exogenous Genes into Cultured Cells Using DEAE-Dextran-MMA Graft Copolymer as a Non-Viral Gene Carrier. 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