{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239689507328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/ijmm.2019.4143"}},{"identifier":{"@type":"DOI","@value":"10.3892/or.2019.7081"}},{"identifier":{"@type":"PMID","@value":"30896835"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription"}],"description":[{"notation":[{"@value":"The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑finger transcription factor, occurs in hypocretin neuron‑ablated transgenic mice, suggesting that PLAGL1 is co‑expressed in hypocretin neurons and regulates hypocretin transcription. The present study examined whether canonical prepro‑hypocretin transcription is functionally modulated by PLAGL1. Double immunostaining indicated that the majority of hypocretin neurons were positive for PLAGL1 immunoreactivity in the nucleus. Notably, PLAGL1 immunoreactivity in hypocretin neurons was altered in response to several conditions affecting hypocretin function. An uneven localization of PLAGL1 was detected in the nuclei of hypocretin neurons following sleep deprivation. Chromatin immunoprecipitation revealed that endogenous PLAGL1 may bind to a putative PLAGL1‑binding site in the proximal region of the hypocretin gene, in the murine hypothalamus. In addition, electroporation of the PLAGL1 expression vector into the fetal hypothalamus promoted hypothalamic hypocretin transcription. These results suggested that PLAGL1 may regulate hypothalamic hypocretin transcription."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751149574784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30399472"},{"@type":"NRID","@value":"1000030399472"},{"@type":"NRID","@value":"9000411647809"},{"@type":"NRID","@value":"9000019040091"},{"@type":"NRID","@value":"9000010977742"},{"@type":"NRID","@value":"9000019188134"},{"@type":"NRID","@value":"9000314081323"},{"@type":"NRID","@value":"9000001228316"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0191138"}],"foaf:name":[{"@value":"Susumu Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239689507206","@type":"Researcher","foaf:name":[{"@value":"Yoshiko Honda"}],"jpcoar:affiliationName":[{"@value":"SLEEP Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156‑8506, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751135572480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00735590"},{"@type":"NRID","@value":"1000000735590"},{"@type":"NRID","@value":"9000406059127"},{"@type":"NRID","@value":"9000406035210"},{"@type":"NRID","@value":"9000369341747"},{"@type":"NRID","@value":"9000406059148"},{"@type":"NRID","@value":"9000406059160"},{"@type":"NRID","@value":"9000308729405"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/koiket"}],"foaf:name":[{"@value":"Taro Koike"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239689507207","@type":"Researcher","foaf:name":[{"@value":"Shizuka Takaku"}],"jpcoar:affiliationName":[{"@value":"SLEEP Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156‑8506, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801211910656","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70599331"},{"@type":"NRID","@value":"1000070599331"},{"@type":"NRID","@value":"9000318138065"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hi-standard"}],"foaf:name":[{"@value":"Souichi Oe"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276166320896","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70457969"},{"@type":"NRID","@value":"1000070457969"},{"@type":"NRID","@value":"9000406059130"},{"@type":"NRID","@value":"9000406035209"},{"@type":"NRID","@value":"9000314080981"},{"@type":"NRID","@value":"9000025033579"},{"@type":"NRID","@value":"9000261643826"},{"@type":"NRID","@value":"9000243857282"},{"@type":"NRID","@value":"9000014620076"},{"@type":"NRID","@value":"9000406059157"},{"@type":"NRID","@value":"9000008955503"},{"@type":"NRID","@value":"9000406059125"},{"@type":"NRID","@value":"9000261643839"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/K92"}],"foaf:name":[{"@value":"Yukie Hirahara"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276175278336","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50548641"},{"@type":"NRID","@value":"1000050548641"},{"@type":"NRID","@value":"9000410037138"},{"@type":"NRID","@value":"9000019186670"},{"@type":"NRID","@value":"9000258520419"},{"@type":"NRID","@value":"9000258431169"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nae_takizawa"}],"foaf:name":[{"@value":"Nae Takizawa"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239689507208","@type":"Researcher","foaf:name":[{"@value":"Takashi Yoshida"}],"jpcoar:affiliationName":[{"@value":"Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka 573‑1191, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133465228672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50309233"},{"@type":"NRID","@value":"1000050309233"},{"@type":"NRID","@value":"9000347044744"},{"@type":"NRID","@value":"9000347074851"},{"@type":"NRID","@value":"9000004693955"},{"@type":"NRID","@value":"9000004696000"},{"@type":"NRID","@value":"9000347044724"},{"@type":"NRID","@value":"9000406059156"},{"@type":"NRID","@value":"9000253492914"},{"@type":"NRID","@value":"9000406059124"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0163261"}],"foaf:name":[{"@value":"Yasuharu Takamori"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801205815424","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20195746"},{"@type":"NRID","@value":"1000020195746"},{"@type":"NRID","@value":"9000001740937"},{"@type":"NRID","@value":"9000347065281"},{"@type":"NRID","@value":"9000347068026"},{"@type":"NRID","@value":"9000404539314"},{"@type":"NRID","@value":"9000314081326"},{"@type":"NRID","@value":"9000014219784"},{"@type":"NRID","@value":"9000004694149"},{"@type":"NRID","@value":"9000002677847"},{"@type":"NRID","@value":"9000347070741"},{"@type":"NRID","@value":"9000347074941"},{"@type":"NRID","@value":"9000003010023"},{"@type":"NRID","@value":"9000283602396"},{"@type":"NRID","@value":"9000403267035"},{"@type":"NRID","@value":"9000255847693"},{"@type":"NRID","@value":"9000018898213"},{"@type":"NRID","@value":"9000392137084"},{"@type":"NRID","@value":"9000323841372"},{"@type":"NRID","@value":"9000001740931"},{"@type":"NRID","@value":"9000347067622"},{"@type":"NRID","@value":"9000002668986"},{"@type":"NRID","@value":"9000347073024"},{"@type":"NRID","@value":"9000347074991"},{"@type":"NRID","@value":"9000254225837"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/SleepLab"}],"foaf:name":[{"@value":"Tohru Kodama"}],"jpcoar:affiliationName":[{"@value":"SLEEP Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156‑8506, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030848250377269121","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000406059164"}],"foaf:name":[{"@value":"Kiyoshi Kurokawa"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801203490048","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00142373"},{"@type":"NRID","@value":"1000000142373"},{"@type":"NRID","@value":"9000020618412"},{"@type":"NRID","@value":"9000406059131"},{"@type":"NRID","@value":"9000406059141"},{"@type":"NRID","@value":"9000347044747"},{"@type":"NRID","@value":"9000347074853"},{"@type":"NRID","@value":"9000286631715"},{"@type":"NRID","@value":"9000254107575"},{"@type":"NRID","@value":"9000005079282"},{"@type":"NRID","@value":"9000406035211"},{"@type":"NRID","@value":"9000019251028"},{"@type":"NRID","@value":"9000000765227"},{"@type":"NRID","@value":"9000314081167"},{"@type":"NRID","@value":"9000020686200"},{"@type":"NRID","@value":"9000347070277"},{"@type":"NRID","@value":"9000347044728"},{"@type":"NRID","@value":"9000253266857"},{"@type":"NRID","@value":"9000257902327"},{"@type":"NRID","@value":"9000014620090"},{"@type":"NRID","@value":"9000004038858"},{"@type":"NRID","@value":"9000017035047"},{"@type":"NRID","@value":"9000406035205"},{"@type":"NRID","@value":"9000347045400"},{"@type":"NRID","@value":"9000253265682"},{"@type":"NRID","@value":"9000252884837"},{"@type":"NRID","@value":"9000000764894"},{"@type":"NRID","@value":"9000020581797"},{"@type":"NRID","@value":"9000004607056"},{"@type":"NRID","@value":"9000243857284"},{"@type":"NRID","@value":"9000006339215"},{"@type":"NRID","@value":"9000369341754"},{"@type":"NRID","@value":"9000283477299"},{"@type":"NRID","@value":"9000004724029"},{"@type":"NRID","@value":"9000020202601"},{"@type":"NRID","@value":"9000314397142"},{"@type":"NRID","@value":"9000022137643"},{"@type":"NRID","@value":"9000019968406"},{"@type":"NRID","@value":"9000406059154"},{"@type":"NRID","@value":"9000314081327"},{"@type":"NRID","@value":"9000258318551"},{"@type":"NRID","@value":"9000257740319"},{"@type":"NRID","@value":"9000279593841"},{"@type":"NRID","@value":"9000007157237"},{"@type":"NRID","@value":"9000005305384"},{"@type":"NRID","@value":"9000406059165"},{"@type":"NRID","@value":"9000347065440"},{"@type":"NRID","@value":"9000254107515"},{"@type":"NRID","@value":"9000392135513"},{"@type":"NRID","@value":"9000021965626"},{"@type":"NRID","@value":"9000308729406"},{"@type":"NRID","@value":"9000253492915"},{"@type":"NRID","@value":"9000257901563"},{"@type":"NRID","@value":"9000314080932"},{"@type":"NRID","@value":"9000254524367"},{"@type":"NRID","@value":"9000000764671"},{"@type":"NRID","@value":"9000018324960"},{"@type":"NRID","@value":"9000406059126"},{"@type":"NRID","@value":"9000314080930"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0018749"}],"foaf:name":[{"@value":"Hisao Yamada"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"11073756"},{"@type":"EISSN","@value":"1791244X"},{"@type":"PISSN","@value":"1021335X"},{"@type":"EISSN","@value":"17912431"}],"prism:publicationName":[{"@value":"International Journal of Molecular Medicine"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2019-03-20"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","createdAt":"2019-03-22","modifiedAt":"2020-07-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Genetics","dc:title":"Genetics"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Medicine","dc:title":"General Medicine"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781914162560","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K08540"},{"@type":"JGN","@value":"JP16K08540"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08540/"}],"notation":[{"@language":"ja","@value":"ナルコレプシーの誘因としてのマイクロビオータを動物モデルで検証する"},{"@language":"en","@value":"Microbiota as a trigger factor for narcolepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782018595456","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K06891"},{"@type":"JGN","@value":"JP19K06891"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06891/"}],"notation":[{"@language":"ja","@value":"単一細胞解析による覚醒制御機構の解明"},{"@language":"en","@value":"Single cell analysis to elucidate the regulatory mechanisms of arousal"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256823695616","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K06747"},{"@type":"JGN","@value":"JP15K06747"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06747/"}],"notation":[{"@language":"ja","@value":"ニューロンおよびグリア細胞における核膜構築タンパク質の多様性"},{"@language":"en","@value":"Variety of the composition of nuclear membrane proteins in neurons and the glial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256890885120","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K08533"},{"@type":"JGN","@value":"JP16K08533"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08533/"}],"notation":[{"@language":"ja","@value":"新規オレキシン転写制御因子の機能解析とナルコレプシーへの関与"},{"@language":"en","@value":"Analysis of novel transcription factors for hypocretin and involvement of narcolepsy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230071771392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239692090112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypothalamo-hypophysial system in rats with autotransplantation of the adrenal cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142933734400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-wide atlas of gene expression in the adult mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144416126976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Zac1 Is an Essential Transcription Factor for Cardiac Morphogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145808945536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reactivation of hyperglycemia-induced hypocretin (<i>HCRT)</i> gene silencing by <i>N</i>-acetyl-<scp>d</scp>-mannosamine in the orexin neurons derived from human iPS cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145926424320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional regulation of the hypocretin/orexin gene by NR6A1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619156094720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nuclear Organization of Mammalian Genomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620200628224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093902073600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Orexin and MCH neurons express c‐Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094443225600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094805344640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure and Function of Human Prepro-orexin Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095093187328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neurogenesis in the ependymal layer of the adult rat 3rd ventricle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658910154624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570117238784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Activation Capacity of the Novel PLAG Family of Zinc Finger Proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570281603072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>hZAC</i>\n            encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570556181632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A genomic atlas of mouse hypothalamic development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570602310656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570653816960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Respiration and autonomic regulation and orexin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043798393984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044707827584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Orexin (Hypocretin) Neurons Contain Dynorphin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044852863360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044988632704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046268025472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of adaptive behaviour during fasting by hypothalamic Foxa2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518985140352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520216296064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993653270912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994646351488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of orexin in motivated behaviours"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995755766784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468421194752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468731817216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypocretin/orexin‐containing neurons are produced in one sharp peak in the developing ventral diencephalon"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944235582208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945228161408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418601142656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418975126656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419410889088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420016947456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895398084864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895691847296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Activities of the Zinc Finger Protein Zac Are Differentially Controlled by DNA Binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895878499200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosome organization and chromatin modification: influence on genome function and evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368477901952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369372245120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369864811008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844656006400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844796005760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Human Prepro-orexin Gene Regulatory Region That Activates Gene Expression in the Lateral Region and Represses It in the Medial Regions of the Hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844912391040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318578501376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793376933504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Regulation of the Hypocretin/Orexin Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793419506560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795422828800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective loss of GABA\n            <sub>B</sub>\n            receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269292699136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IGFBP3 Colocalizes with and Regulates Hypocretin (Orexin)"}]},{"@id":"https://cir.nii.ac.jp/crid/1370850545449195008","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromatin damage patterns shift according to Eu/Heterochromatin replication. The mechanisms of DNA replication"}]},{"@id":"https://cir.nii.ac.jp/crid/1370850545449195274","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modular organization of a hypocretin gene minimal promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206298728448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of orexin in the central regulation of glucose and energy homeostasis [Review]"},{"@value":"Role of orexin in the central regulation of glucose and energy homeostasis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3892/ijmm.2019.4143"},{"@type":"KAKEN","@value":"PRODUCT-22450938"},{"@type":"KAKEN","@value":"PRODUCT-22417162"},{"@type":"KAKEN","@value":"PRODUCT-22450961"},{"@type":"KAKEN","@value":"PRODUCT-22732726"},{"@type":"OPENAIRE","@value":"doi_dedup___::5d8d05d8af22b19c57dde56748b4c3a8"}]}