{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239690917120.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/ijo.2019.4762"}},{"identifier":{"@type":"PMID","@value":"30942440"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Tumor‑suppressive microRNA‑223 targets WDR62 directly in bladder cancer"}],"description":[{"notation":[{"@value":"miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analysis of clinical bladder cancer (BC) specimens. It was revealed that miR‑223 expression was significantly downregulated in BC, suggesting that miR‑223 functions as a tumor suppressor miRNA in BC. The aim of this study was to investigate the functional roles of miR‑223 and to identify its targets in BC. The expression levels of miR‑223 were significantly decreased in our clinical BC specimens. The Cancer Genome Atlas (TCGA) database indicated that miR‑223 expression was related to lymphovascular invasion and distant metastasis. The restoration of miR‑223 expression significantly inhibited tumor aggressiveness and induced apoptosis via caspase‑3/7 activation in BC cells. WD repeat domain 62 (WDR62), a candidate target of miR‑223 according to in silico analyses, has been previously proposed to play a role in neurodevelopment. Direct binding between WDR62 and miR‑223 was confirmed by luciferase assay. The TCGA database revealed positive associations between WDR62 mRNA expression and a higher tumor grade and stage in BC. The knockdown of WDR62 significantly inhibited tumor aggressiveness and induced the apoptosis of BC cells. On the whole, the findings of this study reveal a novel miR‑223 target, oncogenic WDR62, and provided insight into the oncogenesis of BC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239690917128","@type":"Researcher","foaf:name":[{"@value":"Satoshi Sugita"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801192049536","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90642611"},{"@type":"NRID","@value":"1000090642611"},{"@type":"NRID","@value":"9000346987371"}],"foaf:name":[{"@value":"Hirofumi Yoshino"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239690917129","@type":"Researcher","foaf:name":[{"@value":"Masaya Yonemori"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239690917123","@type":"Researcher","foaf:name":[{"@value":"Kazutaka Miyamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239690917120","@type":"Researcher","foaf:name":[{"@value":"Ryosuke Matsushita"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239690917121","@type":"Researcher","foaf:name":[{"@value":"Takashi Sakaguchi"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751158844160","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10642613"},{"@type":"NRID","@value":"1000010642613"},{"@type":"NRID","@value":"9000346987373"}],"foaf:name":[{"@value":"Toshihiko Itesako"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239690917126","@type":"Researcher","foaf:name":[{"@value":"Shuichi Tatarano"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658574920961","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90164144"},{"@type":"NRID","@value":"1000090164144"}],"foaf:name":[{"@value":"Masayuki Nakagawa"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751143885184","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80347103"},{"@type":"NRID","@value":"1000080347103"},{"@type":"NRID","@value":"9000004647786"},{"@type":"NRID","@value":"9000365487639"},{"@type":"NRID","@value":"9000394966293"},{"@type":"NRID","@value":"9000399820491"},{"@type":"NRID","@value":"9000254098661"},{"@type":"NRID","@value":"9000107323067"},{"@type":"NRID","@value":"9000018621530"},{"@type":"NRID","@value":"9000346987376"},{"@type":"NRID","@value":"9000394463931"},{"@type":"NRID","@value":"9000388456467"},{"@type":"NRID","@value":"9000399337396"}],"foaf:name":[{"@value":"Hideki Enokida"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10196439"},{"@type":"EISSN","@value":"17912423"}],"prism:publicationName":[{"@value":"International Journal of Oncology"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2019-03-22","prism:volume":"54","prism:number":"6","prism:startingPage":"2222"},"reviewed":"false","createdAt":"2019-03-22","modifiedAt":"2020-07-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Oncogene%20Proteins","dc:title":"Oncogene Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder","dc:title":"Urinary Bladder"},{"@id":"https://cir.nii.ac.jp/all?q=Datasets%20as%20Topic","dc:title":"Datasets as Topic"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Cycle%20Proteins","dc:title":"Cell Cycle Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Nerve%20Tissue%20Proteins","dc:title":"Nerve Tissue Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Cystectomy","dc:title":"Cystectomy"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=MicroRNAs","dc:title":"MicroRNAs"},{"@id":"https://cir.nii.ac.jp/all?q=Urinary%20Bladder%20Neoplasms","dc:title":"Urinary Bladder Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Knockdown%20Techniques","dc:title":"Gene Knockdown Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Grading","dc:title":"Neoplasm Grading"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781916927872","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K11015"},{"@type":"JGN","@value":"JP16K11015"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11015/"}],"notation":[{"@language":"ja","@value":"尿路上皮癌・増殖シグナルを遮断するマイクロRNAの探索に基づく革新的治療法の開発"},{"@language":"en","@value":"Development of the innovative treatment based on the search of microRNA blocking growth signals in urothelial 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Carcinoma"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235487603456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor‐suppressive <i>micro<scp>RNA</scp>‐143/145</i> cluster targets hexokinase‐2 in renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144186812288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146501434112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"miR-223 decreases cell proliferation and enhances cell apoptosis in acute myeloid leukemia via targeting FBXW7"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705197331968","@type":"Article","resourceType":"学術雑誌論文(journal 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cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567864088704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Most mammalian mRNAs are conserved targets of microRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569051770240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor‐suppressive <i>micro<scp>RNA</scp>‐135a</i> inhibits cancer cell proliferation by targeting the <i>c‐<scp>MYC</scp></i> oncogene in renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570949816832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>MicroRNA-218</i>Inhibits Cell Migration and Invasion in Renal Cell Carcinoma through Targeting<i>Caveolin-2</i>Involved in Focal Adhesion Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593739812992","@type":"Article","resourceType":"学術雑誌論文(journal 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WDR62 is associated with centrosome amplification in human ovarian cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993645171968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Docking interactions of the JNK scaffold protein WDR62"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995109077504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469447439104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular evolution of WDR62, a gene that regulates neocorticogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945665016064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945705515264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"WDR62 is associated with the spindle pole and is mutated in human microcephaly"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420334697344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The functional significance of miR-1 and miR-133a in renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421389256832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Systematic Review of Neoadjuvant and Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893367863424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MiR-223-5p works as an oncomiR in vulvar carcinoma 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