{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239691443456.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/mco.2017.1428"}},{"identifier":{"@type":"PMID","@value":"29181164"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Recent findings on epigenetic gene abnormalities involved in uterine cancer"}],"description":[{"notation":[{"@value":"Selective aberrant genetic effects that do not depend on abnormal DNA sequences are referred to as epigenetic abnormalities and are involved in carcinogenesis. In uterine cancer, various genes involved in apoptosis, cell cycle, DNA repair, cell proliferation and cell adhesion are abnormally methylated, resulting in gene silencing. Reversal of such epigenetic abnormalities in cancer cells is a potential strategy for cancer therapy, and studies on epigenetic abnormalities and treatment methods in uterine cancer are in progress. These include the evaluation of 5-hydroxymethylcytosine, which is present in cancer tissues at lower levels compared with those in normal tissues, as a prognostic marker in cervical cancer; combination therapy with 5-azacytidine and cisplatin; combination treatment focusing on tumor necrosis factor-related apoptosis-inducing ligand in cervical cancer; studies focusing on DNA mismatch repair in endometrial cancer; and use of a demethylating agent to reactivate tumor suppressor genes and inhibit tumor proliferation. Detection of epigenetic changes using biomarkers may be used for histological classification, evaluation of disease progression and identification of compounds that are able to modulate epigenetic changes and may be useful for uterine cancer treatment."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030285133777500672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20433732"},{"@type":"NRID","@value":"1000020433732"},{"@type":"NRID","@value":"9000364333043"},{"@type":"NRID","@value":"9000399223728"},{"@type":"NRID","@value":"9000257773405"},{"@type":"NRID","@value":"9000001321353"},{"@type":"NRID","@value":"9000399223674"},{"@type":"NRID","@value":"9000399243422"},{"@type":"NRID","@value":"9000261045326"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0131068"}],"foaf:name":[{"@value":"Megumi Yanokura"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658545754241","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70265875"},{"@type":"NRID","@value":"1000070265875"},{"@type":"NRID","@value":"9000364289147"},{"@type":"NRID","@value":"9000364314494"},{"@type":"NRID","@value":"9000364596071"},{"@type":"NRID","@value":"9000364596065"},{"@type":"NRID","@value":"9000364419379"},{"@type":"NRID","@value":"9000364435594"},{"@type":"NRID","@value":"9000399537138"},{"@type":"NRID","@value":"9000365008903"},{"@type":"NRID","@value":"9000413780843"},{"@type":"NRID","@value":"9000409869924"},{"@type":"NRID","@value":"9000376549531"},{"@type":"NRID","@value":"9000364251973"},{"@type":"NRID","@value":"9000399223727"},{"@type":"NRID","@value":"9000257773400"},{"@type":"NRID","@value":"9000368921386"},{"@type":"NRID","@value":"9000397819278"},{"@type":"NRID","@value":"9000364349828"},{"@type":"NRID","@value":"9000364301086"},{"@type":"NRID","@value":"9000364404490"},{"@type":"NRID","@value":"9000024281096"},{"@type":"NRID","@value":"9000364579305"},{"@type":"NRID","@value":"9000399221955"},{"@type":"NRID","@value":"9000296672962"},{"@type":"NRID","@value":"9000388476186"},{"@type":"NRID","@value":"9000364553871"},{"@type":"NRID","@value":"9000388449082"},{"@type":"NRID","@value":"9000004697510"},{"@type":"NRID","@value":"9000364587387"},{"@type":"NRID","@value":"9000364503459"},{"@type":"NRID","@value":"9000364301150"},{"@type":"NRID","@value":"9000364291758"},{"@type":"NRID","@value":"9000364408797"},{"@type":"NRID","@value":"9000364434827"},{"@type":"NRID","@value":"9000364441747"},{"@type":"NRID","@value":"9000364552739"},{"@type":"NRID","@value":"9000410966351"},{"@type":"NRID","@value":"9000413583279"},{"@type":"NRID","@value":"9000394961642"},{"@type":"NRID","@value":"9000018181621"},{"@type":"NRID","@value":"9000364463118"},{"@type":"NRID","@value":"9000364464023"},{"@type":"NRID","@value":"9000364458984"},{"@type":"NRID","@value":"9000364301102"},{"@type":"NRID","@value":"9000364405573"},{"@type":"NRID","@value":"9000364526573"},{"@type":"NRID","@value":"9000414942169"},{"@type":"NRID","@value":"9000283564108"},{"@type":"NRID","@value":"9000399941976"},{"@type":"NRID","@value":"9000399946350"},{"@type":"NRID","@value":"9000364403250"},{"@type":"NRID","@value":"9000364399483"},{"@type":"NRID","@value":"9000364503980"},{"@type":"NRID","@value":"9000364475860"},{"@type":"NRID","@value":"9000351064795"},{"@type":"NRID","@value":"9000399223673"},{"@type":"NRID","@value":"9000410287113"},{"@type":"NRID","@value":"9000405698651"},{"@type":"NRID","@value":"9000411242851"},{"@type":"NRID","@value":"9000364373739"},{"@type":"NRID","@value":"9000364426058"},{"@type":"NRID","@value":"9000364503827"},{"@type":"NRID","@value":"9000364548830"},{"@type":"NRID","@value":"9000365008913"},{"@type":"NRID","@value":"9000398996598"},{"@type":"NRID","@value":"9000360550499"},{"@type":"NRID","@value":"9000364333183"},{"@type":"NRID","@value":"9000364463318"},{"@type":"NRID","@value":"9000364447455"},{"@type":"NRID","@value":"9000364413237"},{"@type":"NRID","@value":"9000364429224"},{"@type":"NRID","@value":"9000411077552"},{"@type":"NRID","@value":"9000364526578"},{"@type":"NRID","@value":"9000364554686"},{"@type":"NRID","@value":"9000258090475"},{"@type":"NRID","@value":"9000018214582"},{"@type":"NRID","@value":"9000397963969"},{"@type":"NRID","@value":"9000002841892"},{"@type":"NRID","@value":"9000364339566"},{"@type":"NRID","@value":"9000364260424"},{"@type":"NRID","@value":"9000327927391"},{"@type":"NRID","@value":"9000399243420"},{"@type":"NRID","@value":"9000409798279"},{"@type":"NRID","@value":"9000364349784"},{"@type":"NRID","@value":"9000364372857"},{"@type":"NRID","@value":"9000364429231"},{"@type":"NRID","@value":"9000364480506"},{"@type":"NRID","@value":"9000414537105"},{"@type":"NRID","@value":"9000364332972"},{"@type":"NRID","@value":"9000364289116"},{"@type":"NRID","@value":"9000364501101"},{"@type":"NRID","@value":"9000364527477"},{"@type":"NRID","@value":"9000364349777"},{"@type":"NRID","@value":"9000364206691"},{"@type":"NRID","@value":"9000364475997"},{"@type":"NRID","@value":"9000364552622"},{"@type":"NRID","@value":"9000258533483"},{"@type":"NRID","@value":"9000379561677"},{"@type":"NRID","@value":"9000364508884"},{"@type":"NRID","@value":"9000412055114"},{"@type":"NRID","@value":"9000366496106"},{"@type":"NRID","@value":"9000399593284"},{"@type":"NRID","@value":"9000364331533"},{"@type":"NRID","@value":"9000364500310"},{"@type":"NRID","@value":"9000364525523"},{"@type":"NRID","@value":"9000364407841"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0164010"}],"foaf:name":[{"@value":"Kouji Banno"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276181875456","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10439763"},{"@type":"NRID","@value":"1000010439763"},{"@type":"NRID","@value":"9000364358347"},{"@type":"NRID","@value":"9000017324156"},{"@type":"NRID","@value":"9000307253294"},{"@type":"NRID","@value":"9000399223729"},{"@type":"NRID","@value":"9000258237339"},{"@type":"NRID","@value":"9000356643914"},{"@type":"NRID","@value":"9000360554252"},{"@type":"NRID","@value":"9000242785236"},{"@type":"NRID","@value":"9000399223678"},{"@type":"NRID","@value":"9000360550497"},{"@type":"NRID","@value":"9000356563410"},{"@type":"NRID","@value":"9000006355481"},{"@type":"NRID","@value":"9000366496102"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kobax"}],"foaf:name":[{"@value":"Yusuke Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239691443457","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Nomura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239691443460","@type":"Researcher","foaf:name":[{"@value":"Shigenori Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239691443456","@type":"Researcher","foaf:name":[{"@value":"Eiichiro Tominaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801195753216","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30167788"},{"@type":"NRID","@value":"1000030167788"},{"@type":"NRID","@value":"9000364579961"},{"@type":"NRID","@value":"9000410035257"},{"@type":"NRID","@value":"9000364487867"},{"@type":"NRID","@value":"9000364550453"},{"@type":"NRID","@value":"9000257774372"},{"@type":"NRID","@value":"9000335556810"},{"@type":"NRID","@value":"9000401511528"},{"@type":"NRID","@value":"9000396166533"},{"@type":"NRID","@value":"9000019986253"},{"@type":"NRID","@value":"9000364501098"},{"@type":"NRID","@value":"9000283493417"},{"@type":"NRID","@value":"9000364581634"},{"@type":"NRID","@value":"9000364549965"},{"@type":"NRID","@value":"9000045493746"},{"@type":"NRID","@value":"9000364533668"},{"@type":"NRID","@value":"9000364530444"},{"@type":"NRID","@value":"9000364577450"},{"@type":"NRID","@value":"9000257773869"},{"@type":"NRID","@value":"9000336381625"},{"@type":"NRID","@value":"9000388476187"},{"@type":"NRID","@value":"9000019140342"},{"@type":"NRID","@value":"9000409846626"},{"@type":"NRID","@value":"9000257774262"},{"@type":"NRID","@value":"9000365489208"},{"@type":"NRID","@value":"9000364501111"},{"@type":"NRID","@value":"9000364503089"},{"@type":"NRID","@value":"9000364488588"},{"@type":"NRID","@value":"9000364535259"},{"@type":"NRID","@value":"9000364541772"},{"@type":"NRID","@value":"9000364558661"},{"@type":"NRID","@value":"9000399790801"},{"@type":"NRID","@value":"9000364582160"},{"@type":"NRID","@value":"9000021362057"},{"@type":"NRID","@value":"9000364501776"},{"@type":"NRID","@value":"9000283563767"},{"@type":"NRID","@value":"9000283563315"},{"@type":"NRID","@value":"9000257773000"},{"@type":"NRID","@value":"9000257773300"},{"@type":"NRID","@value":"9000283115114"},{"@type":"NRID","@value":"9000412286136"},{"@type":"NRID","@value":"9000413583281"},{"@type":"NRID","@value":"9000414345866"},{"@type":"NRID","@value":"9000364463122"},{"@type":"NRID","@value":"9000283564110"},{"@type":"NRID","@value":"9000399337662"},{"@type":"NRID","@value":"9000404670474"},{"@type":"NRID","@value":"9000011152900"},{"@type":"NRID","@value":"9000413511919"},{"@type":"NRID","@value":"9000364503989"},{"@type":"NRID","@value":"9000364475868"},{"@type":"NRID","@value":"9000351064787"},{"@type":"NRID","@value":"9000405698655"},{"@type":"NRID","@value":"9000411242852"},{"@type":"NRID","@value":"9000404519782"},{"@type":"NRID","@value":"9000001050251"},{"@type":"NRID","@value":"9000019061821"},{"@type":"NRID","@value":"9000364501116"},{"@type":"NRID","@value":"9000364541229"},{"@type":"NRID","@value":"9000364548838"},{"@type":"NRID","@value":"9000399219007"},{"@type":"NRID","@value":"9000283563695"},{"@type":"NRID","@value":"9000283563428"},{"@type":"NRID","@value":"9000283564007"},{"@type":"NRID","@value":"9000257773706"},{"@type":"NRID","@value":"9000414564961"},{"@type":"NRID","@value":"9000360550501"},{"@type":"NRID","@value":"9000399830776"},{"@type":"NRID","@value":"9000364447459"},{"@type":"NRID","@value":"9000364503077"},{"@type":"NRID","@value":"9000411394940"},{"@type":"NRID","@value":"9000258090477"},{"@type":"NRID","@value":"9000364581474"},{"@type":"NRID","@value":"9000364522072"},{"@type":"NRID","@value":"9000364488734"},{"@type":"NRID","@value":"9000364529889"},{"@type":"NRID","@value":"9000326656041"},{"@type":"NRID","@value":"9000399243425"},{"@type":"NRID","@value":"9000409798281"},{"@type":"NRID","@value":"9000338422429"},{"@type":"NRID","@value":"9000411277882"},{"@type":"NRID","@value":"9000364517909"},{"@type":"NRID","@value":"9000364480512"},{"@type":"NRID","@value":"9000364539814"},{"@type":"NRID","@value":"9000404851411"},{"@type":"NRID","@value":"9000405930473"},{"@type":"NRID","@value":"9000257773328"},{"@type":"NRID","@value":"9000018210765"},{"@type":"NRID","@value":"9000261045330"},{"@type":"NRID","@value":"9000364501105"},{"@type":"NRID","@value":"9000364527487"},{"@type":"NRID","@value":"9000364547090"},{"@type":"NRID","@value":"9000283564491"},{"@type":"NRID","@value":"9000334741667"},{"@type":"NRID","@value":"9000259341892"},{"@type":"NRID","@value":"9000364579832"},{"@type":"NRID","@value":"9000364435472"},{"@type":"NRID","@value":"9000283564369"},{"@type":"NRID","@value":"9000411481856"},{"@type":"NRID","@value":"9000415126181"},{"@type":"NRID","@value":"9000399601628"},{"@type":"NRID","@value":"9000364508893"},{"@type":"NRID","@value":"9000364488577"},{"@type":"NRID","@value":"9000364528077"},{"@type":"NRID","@value":"9000364526813"},{"@type":"NRID","@value":"9000326655780"},{"@type":"NRID","@value":"9000257772638"},{"@type":"NRID","@value":"9000409371840"},{"@type":"NRID","@value":"9000399593285"},{"@type":"NRID","@value":"9000364300393"},{"@type":"NRID","@value":"9000364390571"},{"@type":"NRID","@value":"9000364500217"},{"@type":"NRID","@value":"9000364390740"},{"@type":"NRID","@value":"9000364371920"},{"@type":"NRID","@value":"9000364470344"},{"@type":"NRID","@value":"9000364314245"},{"@type":"NRID","@value":"9000364269601"},{"@type":"NRID","@value":"9000364407713"},{"@type":"NRID","@value":"9000364211732"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0024642"}],"foaf:name":[{"@value":"Daisuke Aoki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"20499450"},{"@type":"EISSN","@value":"20499469"}],"prism:publicationName":[{"@value":"Molecular and Clinical Oncology"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2017-09-20","prism:volume":"7","prism:number":"5","prism:startingPage":"733","prism:endingPage":"737"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","createdAt":"2017-09-20","modifiedAt":"2019-10-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cancer%20Research","dc:title":"Cancer Research"},{"@id":"https://cir.nii.ac.jp/all?q=Oncology","dc:title":"Oncology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781853315200","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K10730"},{"@type":"JGN","@value":"JP15K10730"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10730/"}],"notation":[{"@language":"ja","@value":"卵巣癌細胞の薬剤感受性と遺伝子プロファイルに基づいた治療法の確立"},{"@language":"en","@value":"Towards precision medicine for ovarian cancer using drug sensitivity and resistance testing and genomic analysis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011146203132928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146321101312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modal variety of microsatellite instability in human endometrial carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146409316736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>CADM1</i>\n                    ,\n                    <i>MAL</i>\n                    and\n                    <i>miR124-2</i>\n                    methylation analysis in cervical scrapes to detect cervical and endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693660091776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>miR-152</i>\n                    Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619263893888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620831945472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNMT Inhibitors and HDAC Inhibitors Regulate E-Cadherin and Bcl-2 Expression in Endometrial Carcinoma in vitro and in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621089229056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093906457600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypermethylation of E-cadherin in endometrial carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093970643200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095483801088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CCNA1 Promoter Methylation: a Potential Marker for Grading Papanicolaou Smear Cervical Squamous Intraepithelial Lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570877138432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>RASSF1A</i> hypermethylation and its inverse correlation with <i>BRAF</i> and/or <i>KRAS</i> mutations in MSI‐associated endometrial carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043583541248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microsatellite Instability Predicts Clinical Outcome in Radiation-Treated Endometrioid Endometrial Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043658719616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inactivation of the Candidate Tumor Suppressor\n                    <i>Par-4</i>\n                    in Endometrial Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045263594624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"5-Hydroxymethylcytosine expression is associated with poor survival in cervical squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046209610496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Folate Deficiency and FHIT Hypermethylation and HPV 16 Infection Promote Cervical Cancerization"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518377098880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518499819392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic inactivation of <scp>TRAIL</scp> decoy receptors at 8p12‐21.3 commonly deleted region confers sensitivity to <scp>A</scp>po2L/<scp>trail</scp>‐<scp>C</scp>isplatin combination therapy in cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519230964352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519636853760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520981783808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995544849152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter hypermethylation of the tumor-suppressor genes RASSF1A, GSTP1 and CDH1 in endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995932153216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation and silencing of the retinoic acid receptor-β2 gene in cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468719968640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468906724736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469656544000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470363948032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sequential gene promoter methylation during HPV-induced cervical carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945204586368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter Hypermethylation of <b>\n                     <i>FANCF</i>\n                  </b>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945247397888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inactivation of the human androgen receptor gene is associated with CpG hypermethylation in uterine endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945399531776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alterations in gene promoter methylation and transcript expression induced by cisplatin in comparison to 5-Azacytidine in HeLa and SiHa cervical cancer cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945518897280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945936978944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between dense CADM1 promoter methylation and reduced protein expression in high‐grade CIN and cervical SCC"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419171834240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Promoter Hypermethylation of the <i>RASSF1A</i> Gene With Prognostic Parameters in Endometrial Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419668381440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter Methylation and Differential Expression of π-Class Glutathione S-Transferase in Endometrial Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420204063872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation analysis of SFRP genes family in cervical adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420508619136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893599255936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure and function of the components of the human DNA mismatch repair system"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894192428544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter hypermethylation contributes to <scp><scp>TIMP</scp></scp><i>3</i> down‐regulation in high stage endometrioid endometrial carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896215693184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p16 INK4A Alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368746162944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical Assessment of O<sup>6</sup>-Methylguanine-DNA Methyltransferase (MGMT) and Its Relationship with p53 Expression in Endometrial Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370296548224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844235424384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TESTIN was commonly hypermethylated and involved in the epithelial-mesenchymal transition of endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845374393344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846357263744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318597625216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recurrent patterns of DNA methylation in the<i>ZNF154,</i><i>CASP8</i>, and<i>VHL</i>promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319776766592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319787606144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320803731712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320837582720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"APC promoter hypermethylation is an early event in endometrial tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793842977152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Restoration of fragile histidine triad (\n            <i>FHIT</i>\n            ) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794644570624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA Promoter Methylation-dependent Transcription of the Double C2-like Domain β (DOC2B) Gene Regulates Tumor Growth in Human Cervical Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795201935488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795636768896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269325488256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269359691904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HDAC as a Therapeutic Target for Treatment of Endometrial Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269369114240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypermethylation of <i>SOX2</i> Promoter in Endometrial Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269744225664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Status and Significance of CpG Island Methylator Phenotype in Endometrial Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269898956928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypermethylation in promoter region of E‐cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270649230080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270707272192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of <i>CDH13</i> Hypermethylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270773017728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892488834","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"microRNA-30c negatively regulates endometrial cancer cells by targeting metastasis-associated gene-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892488845","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic DNA hypermethylation: Clinical applications in endometrial cancer (Review)"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892488966","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aberrant methylation during cervical carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892488968","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"5′-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892489090","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892489098","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1370006918892489225","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976306473088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adenomatous polyposis coli (APC) : a multi-functional tumor suppressor gene"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3892/mco.2017.1428"},{"@type":"KAKEN","@value":"PRODUCT-21864519"},{"@type":"OPENAIRE","@value":"doi_dedup___::074d6e92623784b453de6b0961954d25"}]}