{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239694092160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/or.2012.1908"}},{"identifier":{"@type":"URI","@value":"https://spandidos-publications.com/10.3892/or.2012.1908/download"}},{"identifier":{"@type":"PMID","@value":"22797671"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung"}],"description":[{"notation":[{"@value":"Recently, a novel fusion gene resulting from a linkage between the kinesin             family member 5B gene (KIF5B; 10p11.22) and the rearranged during transfection             gene (RET; 10q11.21) was identified in non-small cell lung cancer (NSCLC). However,             the correlation between the KIF5B/RET fusion gene status and the clinicopathological             features of surgically-treated lung cancer has not been well characterized. In             this study, we have independently investigated the KIF5B/RET fusion gene status             in 371 surgically-treated NSCLCs (270 were adenocarcinomas and 101 were squamous             cell carcinomas), 60 breast cancers, 11 metastatic lung cancers from colon cancers             and thyroid papillary adenocarcinoma cases at the Nagoya City University Hospital.             The fusion gene status was analyzed by an RT-PCR-based assay and by using direct             sequencing. We detected 3 of 270 cases of KIF5B/RET fusion genes in adenocarcinomas             (1.1%) consisting of female and never smokers with mixed subtype adenocarcinomas.             The fusion genes were detected exclusively with other mutations, such as EGFR,             Kras, Braf, erbB2 mutations, and EML4/ALK fusion. KIF5B/RET fusion was not detected             in the cases with squamous cell carcinoma or other types of cancers. From the             3 cases, 2 were KIF5B (exon 15); RET (exon 12) fusions with papillary dominant             and 1 case was KIF5B (exon 22); RET (exon 12) fusion with solid dominant adenocarcinoma.             The matched normal lung tissues did not display translocation. We reported KIF5B/RET             fusion genes as a driver somatic mutation of lung adenocarcinomas. The cinicopathological             backgrounds of the KIF5B/RET fusion-positive patients were similar with those             of the EML4/ALK fusion-positive patients. The chimeric oncogene may be a promising             molecular target for the personalized diagnosis and treatment of NSCLC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239694092161","@type":"Researcher","foaf:name":[{"@value":"KEISUKE YOKOTA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092164","@type":"Researcher","foaf:name":[{"@value":"HIDEFUMI SASAKI"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801209633280","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50529170"},{"@type":"NRID","@value":"1000050529170"},{"@type":"NRID","@value":"9000255958431"},{"@type":"NRID","@value":"9000415225731"},{"@type":"NRID","@value":"9000014163525"},{"@type":"NRID","@value":"9000317562543"},{"@type":"NRID","@value":"9000263041802"},{"@type":"NRID","@value":"9000413383797"},{"@type":"NRID","@value":"9000363213282"},{"@type":"NRID","@value":"9000410654251"},{"@type":"NRID","@value":"9000256635590"},{"@type":"NRID","@value":"9000242073283"},{"@type":"NRID","@value":"9000253386641"},{"@type":"NRID","@value":"9000359880602"},{"@type":"NRID","@value":"9000253388111"},{"@type":"NRID","@value":"9000021265368"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0155145"}],"foaf:name":[{"@value":"KATSUHIRO OKUDA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092165","@type":"Researcher","foaf:name":[{"@value":"SHIGEKI SHIMIZU"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092160","@type":"Researcher","foaf:name":[{"@value":"MASAYUKI SHITARA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092167","@type":"Researcher","foaf:name":[{"@value":"YU HIKOSAKA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092162","@type":"Researcher","foaf:name":[{"@value":"SATORU MORIYAMA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092166","@type":"Researcher","foaf:name":[{"@value":"MOTOKI YANO"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694092168","@type":"Researcher","foaf:name":[{"@value":"YOSHITAKA FUJII"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1021335X"},{"@type":"EISSN","@value":"17912431"}],"prism:publicationName":[{"@value":"Oncology Reports"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2012-07-13","prism:volume":"28","prism:number":"4","prism:startingPage":"1187","prism:endingPage":"1192"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://spandidos-publications.com/10.3892/or.2012.1908/download"}],"createdAt":"2012-07-13","modifiedAt":"2018-01-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20B-raf","dc:title":"Proto-Oncogene Proteins B-raf"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Neoplasms","dc:title":"Lung Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Kinesins","dc:title":"Kinesins"},{"@id":"https://cir.nii.ac.jp/all?q=Adenocarcinoma%20of%20Lung","dc:title":"Adenocarcinoma of Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Adenocarcinoma","dc:title":"Adenocarcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=Translocation,%20Genetic","dc:title":"Translocation, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Asian%20People","dc:title":"Asian People"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Non-Small-Cell%20Lung","dc:title":"Carcinoma, Non-Small-Cell Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Thyroid%20Neoplasms","dc:title":"Thyroid Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-ret","dc:title":"Proto-Oncogene Proteins c-ret"},{"@id":"https://cir.nii.ac.jp/all?q=Smoking","dc:title":"Smoking"},{"@id":"https://cir.nii.ac.jp/all?q=Exons","dc:title":"Exons"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=ErbB%20Receptors","dc:title":"ErbB Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Adenocarcinoma,%20Papillary","dc:title":"Adenocarcinoma, Papillary"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Squamous%20Cell","dc:title":"Carcinoma, Squamous Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Fusion","dc:title":"Gene Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Colorectal%20Neoplasms","dc:title":"Colorectal Neoplasms"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782177216384","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23659674"},{"@type":"JGN","@value":"JP23659674"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659674/"}],"notation":[{"@language":"ja","@value":"新手法を用いた膜受容体関連遺伝子異常検索"},{"@language":"en","@value":"Investigation for tyrosine kinase mutations using novel methods"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782215201920","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24592097"},{"@type":"JGN","@value":"JP24592097"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592097/"}],"notation":[{"@language":"ja","@value":"リアルタイムＰＣＲを用いたチロシンキナーゼ遺伝子変異検索"},{"@language":"en","@value":"Investigation of tyrosine kinase gene mutation using real-time PCR assay"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677040916608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4-ALK Fusion Gene."}]},{"@id":"https://cir.nii.ac.jp/crid/1360001113994997248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The\n                    <i>EML4‐ALK</i>\n                    fusion gene is 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crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470805372416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471162656256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lung cancer in never smokers: Change of a mindset in the molecular era"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944217428736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Worse Disease-Free Survival in Never-Smokers with ALK+ Lung Adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945063531520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a novel imatinib responsive 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