{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239694690560.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3892/or.2017.5586"}},{"identifier":{"@type":"URI","@value":"https://spandidos-publications.com/10.3892/or.2017.5586/download"}},{"identifier":{"@type":"PMID","@value":"28440494"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer"}],"description":[{"notation":[{"@value":"Tumor-associated macrophages of the M2 phenotype promote tumor proliferation and are associated with a poor prognosis in patients with various malignancies, including gastric cancer with peritoneal dissemination. The present study assessed whether paclitaxel (PTX) suppresses M2 macrophages, by acting as a Toll-like receptor 4 (TLR4) agonist. Macrophages derived from the THP-1 monocytic cell line and peripheral blood mononuclear cell (PBMC)-derived macrophages were cultured with gastric cancer cells in medium containing PTX, at a concentration that did not affect cell proliferation. The effects of PTX on macrophage expression of CD204, a marker of M2 macrophages and NOS2, a marker of M1 macrophages, was evaluated by western blotting. The ability of PTX to stimulate intranuclear translocation of NF-κB was determined by evaluating the expression of the p65 subunit of NF-κB. In THP-1 macrophages, low-dose PTX (1 and 5 nM) inhibited the expression of CD204, enhanced the expression of NOS2, and significantly suppressed the phosphorylation of Stat3, which is essential for the M2 phenotype. Low-dose PTX also inhibited CD204 expression in primary macrophages derived from PBMCs. PTX treatment of THP-1 macrophages for 1 h induced marked intranuclear translocation of NF-κB p65. Low-dose PTX inhibited the M2 phenotype and induced the M1 phenotype via TLR4 signaling, suggesting that low-dose PTX can alter the macrophage phenotype, whereas clinical doses can kill cancer cells. These results suggest that the anticancer effects of PTX are due both to its cytotoxic and immunomodulatory activities."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239694690569","@type":"Researcher","foaf:name":[{"@value":"Takahisa Yamaguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276181576448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10301194"},{"@type":"NRID","@value":"1000010301194"},{"@type":"NRID","@value":"9000412180867"},{"@type":"NRID","@value":"9000412180878"},{"@type":"NRID","@value":"9000391413104"},{"@type":"NRID","@value":"9000409576593"},{"@type":"NRID","@value":"9000409576608"},{"@type":"NRID","@value":"9000252853440"},{"@type":"NRID","@value":"9000283465757"},{"@type":"NRID","@value":"9000258278793"},{"@type":"NRID","@value":"9000261046384"},{"@type":"NRID","@value":"9000023273258"},{"@type":"NRID","@value":"9000366129372"},{"@type":"NRID","@value":"9000391414164"},{"@type":"NRID","@value":"9000256626905"},{"@type":"NRID","@value":"9000402378386"},{"@type":"NRID","@value":"9000293529403"},{"@type":"NRID","@value":"9000334423304"},{"@type":"NRID","@value":"9000368921383"},{"@type":"NRID","@value":"9000262364854"},{"@type":"NRID","@value":"9000409576674"},{"@type":"NRID","@value":"9000283693849"},{"@type":"NRID","@value":"9000256618284"},{"@type":"NRID","@value":"9000015346153"},{"@type":"NRID","@value":"9000023268086"},{"@type":"NRID","@value":"9000326269077"},{"@type":"NRID","@value":"9000391414135"},{"@type":"NRID","@value":"9000283693892"},{"@type":"NRID","@value":"9000322101493"},{"@type":"NRID","@value":"9000279907594"},{"@type":"NRID","@value":"9000391414153"},{"@type":"NRID","@value":"9000237898405"},{"@type":"NRID","@value":"9000391416424"},{"@type":"NRID","@value":"9000391718270"},{"@type":"NRID","@value":"9000286630944"},{"@type":"NRID","@value":"9000253370910"},{"@type":"NRID","@value":"9000258276468"},{"@type":"NRID","@value":"9000287287155"},{"@type":"NRID","@value":"9000409576630"},{"@type":"NRID","@value":"9000409576649"},{"@type":"NRID","@value":"9000283693843"},{"@type":"NRID","@value":"9000347126292"},{"@type":"NRID","@value":"9000022474544"},{"@type":"NRID","@value":"9000380492647"},{"@type":"NRID","@value":"9000401421092"},{"@type":"NRID","@value":"9000250185724"},{"@type":"NRID","@value":"9000287287233"},{"@type":"NRID","@value":"9000409576718"},{"@type":"NRID","@value":"9000391413183"},{"@type":"NRID","@value":"9000258075574"},{"@type":"NRID","@value":"9000258111705"},{"@type":"NRID","@value":"9000412412330"},{"@type":"NRID","@value":"9000304614550"},{"@type":"NRID","@value":"9000399796421"},{"@type":"NRID","@value":"9000391416505"},{"@type":"NRID","@value":"9000391418203"},{"@type":"NRID","@value":"9000253387169"},{"@type":"NRID","@value":"9000253370816"},{"@type":"NRID","@value":"9000304614328"},{"@type":"NRID","@value":"9000237898908"},{"@type":"NRID","@value":"9000409576565"},{"@type":"NRID","@value":"9000409576578"},{"@type":"NRID","@value":"9000351097656"},{"@type":"NRID","@value":"9000411376511"},{"@type":"NRID","@value":"9000014191141"},{"@type":"NRID","@value":"9000107365836"},{"@type":"NRID","@value":"9000023273277"},{"@type":"NRID","@value":"9000023320681"},{"@type":"NRID","@value":"9000326269086"},{"@type":"NRID","@value":"9000237897689"},{"@type":"NRID","@value":"9000356480742"},{"@type":"NRID","@value":"9000391418683"},{"@type":"NRID","@value":"9000351097621"},{"@type":"NRID","@value":"9000391415516"},{"@type":"NRID","@value":"9000363364784"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/S1DOC-ip1985"}],"foaf:name":[{"@value":"Sachio Fushida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690564","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690570","@type":"Researcher","foaf:name":[{"@value":"Tomoya Tsukada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690565","@type":"Researcher","foaf:name":[{"@value":"Jun Kinoshita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690573","@type":"Researcher","foaf:name":[{"@value":"Katsunobu Oyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690567","@type":"Researcher","foaf:name":[{"@value":"Tomoharu Miyashita"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801204038144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00436825"},{"@type":"NRID","@value":"1000000436825"},{"@type":"NRID","@value":"9000412180873"},{"@type":"NRID","@value":"9000412180862"},{"@type":"NRID","@value":"9000253377328"},{"@type":"NRID","@value":"9000398632071"},{"@type":"NRID","@value":"9000258280054"},{"@type":"NRID","@value":"9000409576586"},{"@type":"NRID","@value":"9000409576602"},{"@type":"NRID","@value":"9000283465753"},{"@type":"NRID","@value":"9000000753032"},{"@type":"NRID","@value":"9000261046382"},{"@type":"NRID","@value":"9000002890877"},{"@type":"NRID","@value":"9000366129378"},{"@type":"NRID","@value":"9000253359201"},{"@type":"NRID","@value":"9000388447710"},{"@type":"NRID","@value":"9000402378384"},{"@type":"NRID","@value":"9000293529400"},{"@type":"NRID","@value":"9000309574809"},{"@type":"NRID","@value":"9000290132945"},{"@type":"NRID","@value":"9000258224228"},{"@type":"NRID","@value":"9000412259108"},{"@type":"NRID","@value":"9000334423310"},{"@type":"NRID","@value":"9000275834129"},{"@type":"NRID","@value":"9000262364848"},{"@type":"NRID","@value":"9000409576655"},{"@type":"NRID","@value":"9000409576680"},{"@type":"NRID","@value":"9000324996429"},{"@type":"NRID","@value":"9000255888594"},{"@type":"NRID","@value":"9000023268143"},{"@type":"NRID","@value":"9000326269082"},{"@type":"NRID","@value":"9000253379437"},{"@type":"NRID","@value":"9000258223079"},{"@type":"NRID","@value":"9000283465951"},{"@type":"NRID","@value":"9000412227376"},{"@type":"NRID","@value":"9000412227385"},{"@type":"NRID","@value":"9000379610141"},{"@type":"NRID","@value":"9000253382098"},{"@type":"NRID","@value":"9000018265735"},{"@type":"NRID","@value":"9000002154010"},{"@type":"NRID","@value":"9000283465835"},{"@type":"NRID","@value":"9000263063810"},{"@type":"NRID","@value":"9000237898411"},{"@type":"NRID","@value":"9000413562883"},{"@type":"NRID","@value":"9000413562893"},{"@type":"NRID","@value":"9000278500398"},{"@type":"NRID","@value":"9000409576637"},{"@type":"NRID","@value":"9000409576617"},{"@type":"NRID","@value":"9000283328396"},{"@type":"NRID","@value":"9000253379307"},{"@type":"NRID","@value":"9000253367428"},{"@type":"NRID","@value":"9000380492654"},{"@type":"NRID","@value":"9000250185721"},{"@type":"NRID","@value":"9000287287220"},{"@type":"NRID","@value":"9000409576701"},{"@type":"NRID","@value":"9000409576723"},{"@type":"NRID","@value":"9000253369693"},{"@type":"NRID","@value":"9000258075573"},{"@type":"NRID","@value":"9000403306609"},{"@type":"NRID","@value":"9000399796424"},{"@type":"NRID","@value":"9000391416722"},{"@type":"NRID","@value":"9000394465456"},{"@type":"NRID","@value":"9000237898899"},{"@type":"NRID","@value":"9000412180893"},{"@type":"NRID","@value":"9000412180884"},{"@type":"NRID","@value":"9000409576558"},{"@type":"NRID","@value":"9000409576572"},{"@type":"NRID","@value":"9000351097655"},{"@type":"NRID","@value":"9000399348172"},{"@type":"NRID","@value":"9000399356301"},{"@type":"NRID","@value":"9000258015419"},{"@type":"NRID","@value":"9000258276603"},{"@type":"NRID","@value":"9000411376508"},{"@type":"NRID","@value":"9000356889049"},{"@type":"NRID","@value":"9000023598446"},{"@type":"NRID","@value":"9000413562847"},{"@type":"NRID","@value":"9000413562859"},{"@type":"NRID","@value":"9000356480733"},{"@type":"NRID","@value":"9000347545456"},{"@type":"NRID","@value":"9000273024269"},{"@type":"NRID","@value":"9000365043798"},{"@type":"NRID","@value":"9000258278516"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sanborn-tj"}],"foaf:name":[{"@value":"Hidehiro Tajima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690572","@type":"Researcher","foaf:name":[{"@value":"Itasu Ninomiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276159549696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10399040"},{"@type":"NRID","@value":"1000010399040"},{"@type":"NRID","@value":"9000023397514"},{"@type":"NRID","@value":"9000290134195"},{"@type":"NRID","@value":"9000396184485"},{"@type":"NRID","@value":"9000242446780"},{"@type":"NRID","@value":"9000252815669"},{"@type":"NRID","@value":"9000334423312"},{"@type":"NRID","@value":"9000381469666"},{"@type":"NRID","@value":"9000283408035"},{"@type":"NRID","@value":"9000002620173"},{"@type":"NRID","@value":"9000331452520"},{"@type":"NRID","@value":"9000409578811"},{"@type":"NRID","@value":"9000255959081"},{"@type":"NRID","@value":"9000283280899"},{"@type":"NRID","@value":"9000022765993"},{"@type":"NRID","@value":"9000409578867"},{"@type":"NRID","@value":"9000409578850"},{"@type":"NRID","@value":"9000356557086"},{"@type":"NRID","@value":"9000365492724"},{"@type":"NRID","@value":"9000409578891"},{"@type":"NRID","@value":"9000409578876"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/smunesue"}],"foaf:name":[{"@value":"Seiichi Munesue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690571","@type":"Researcher","foaf:name":[{"@value":"Ai Harashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690568","@type":"Researcher","foaf:name":[{"@value":"Shinichi Harada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690563","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239694690566","@type":"Researcher","foaf:name":[{"@value":"Tetsuo Ohta"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1021335X"},{"@type":"EISSN","@value":"17912431"}],"prism:publicationName":[{"@value":"Oncology Reports"}],"dc:publisher":[{"@value":"Spandidos Publications"}],"prism:publicationDate":"2017-04-19","prism:volume":"37","prism:number":"6","prism:startingPage":"3341","prism:endingPage":"3350"},"reviewed":"false","url":[{"@id":"https://spandidos-publications.com/10.3892/or.2017.5586/download"}],"createdAt":"2017-04-19","modifiedAt":"2023-08-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=STAT3%20Transcription%20Factor","dc:title":"STAT3 Transcription Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Paclitaxel","dc:title":"Paclitaxel"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factor%20RelA","dc:title":"Transcription Factor RelA"},{"@id":"https://cir.nii.ac.jp/all?q=Nitric%20Oxide%20Synthase%20Type%20II","dc:title":"Nitric Oxide Synthase Type II"},{"@id":"https://cir.nii.ac.jp/all?q=Scavenger%20Receptors,%20Class%20A","dc:title":"Scavenger Receptors, Class A"},{"@id":"https://cir.nii.ac.jp/all?q=Coculture%20Techniques","dc:title":"Coculture Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Toll-Like%20Receptor%204","dc:title":"Toll-Like Receptor 4"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach%20Neoplasms","dc:title":"Stomach Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Leukocytes,%20Mononuclear","dc:title":"Leukocytes, Mononuclear"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257276582912","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26430068"},{"@type":"JGN","@value":"JP26430068"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430068/"}],"notation":[{"@language":"ja","@value":"線虫をモデルとした光刺激と寿命・老化制御の分子基盤の解明"},{"@language":"en","@value":"Molecular basis of lifespan and aging by exposing LED light in C. elegans"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564287882094976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231296337152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239689857152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142766273152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144358989952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pilot study of a combination of S-1 and paclitaxel for patients with peritoneal metastasis from gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144654227584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LPS induction of gene expression in human monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145589573760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intraperitoneal Chemotherapy as a Multimodal Treatment for Gastric Cancer Patients with Peritoneal Metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695889346816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antitumor Effect of Paclitaxel Is Mediated by Inhibition of Myeloid-Derived Suppressor Cells and Chronic Inflammation in the Spontaneous Melanoma Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618728863232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619372236672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor associated regulatory dendritic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168099345536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor associated macrophage expressing <scp>CD</scp>204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168175456896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T‐cell lymphoma (AITL)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568470770868352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093884225664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II study of paclitaxel (BMS-181339) intravenously infused over 3 hours for advanced or metastatic breast cancer in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095942321920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645722328704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Low-dose paclitaxel modulates tumour fibrosis in gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568970222976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of tumor‐associated macrophages on invasive ductal carcinoma of the pancreas head"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570049848448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor-Associated Macrophages as Targets for Tumor Immunotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570681758976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The taxoids: paclitaxel and docetaxel"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571569011584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-κB Signaling in Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043526517504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043763344768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043986123136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hallmarks of cancer: Interactions with the tumor stroma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045626072832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting Microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046078207232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519067194752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peritoneal carcinomatosis from non-gynecologic malignancies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519405687680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519599843968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520145442688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Milky spot macrophages remodeled by gastric cancer cells promote peritoneal mesothelial cell injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520757436928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994591542144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered macrophage differentiation and immune dysfunction in tumor development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995661809408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized Study to Assess the Effectiveness of Slow- and Moderate-Release Polymer-Based Paclitaxel-Eluting Stents for Coronary Artery Lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996208265856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stromal cells can contribute oncogenic signals"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996252580864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinct Role of Macrophages in Different Tumor Microenvironments"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468930261888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global cancer statistics in the year 2000"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470696158592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II Study of 3-Hour Infusion of Paclitaxel in Patients with Previously Untreated Stage III and IV Non-Small Cell Lung Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943758758400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fibroblasts in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419528493312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A long-term follow-up study of patients with gastric cancer detected by mass screening"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419566957312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420625771264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage plasticity and polarization: in vivo veritas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893334708096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895836769280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369309743744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370265841792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized Phase III Study of 5-Fluorouracil Continuous Infusion vs. Sequential Methotrexate and 5-Fluorouracil Therapy in Far Advanced Gastric Cancer with Peritoneal Metastasis (JCOG0106)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845996524032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti‐tumour strategies aiming to target tumour‐associated macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318789136768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Is the class A macrophage scavenger receptor (SR-A) multifunctional? — The mouse’s tale"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793772324736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage Polarization at the Crossroad Between HIV-1 Infection and Cancer Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270566440320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse Toll-like Receptor 4·MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849394933799690","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II study of paclitaxel (BMS-181339) in patients with ovarian cancer by 3-hour intravenous infusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849394933799809","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual anti-cancer effects of weekly intraperitoneal docetaxel in treatment of advanced gastric cancer patients with peritoneal carcinomatosis: A feasibility and pharmacokinetic study"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849394933799814","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of p34cdc2 coincident with taxol-induced apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849394933799945","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peritoneal carcinomatosis and lymph node metastasis are prognostic indicators in patients with Borrmann type IV gastric carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849394933800066","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor-associated macrophage (TAM) infiltration in gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601278900480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Significance of M2-polarized tumor-associated macrophage in pancreatic cancer"},{"@value":"Significance of M2‐polarized tumor‐associated macrophage in pancreatic cancer"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3892/or.2017.5586"},{"@type":"KAKEN","@value":"PRODUCT-21075808"},{"@type":"OPENAIRE","@value":"doi_dedup___::f49eda8ac3fcaf6e664d1a696b583fee"},{"@type":"CROSSREF","@value":"10.1186/s12885-020-07477-x_references_DOI_3XDAIyMQcWs2p7DMgmmY1xdlxc1"},{"@type":"CROSSREF","@value":"10.1111/pin.12853_references_DOI_3XDAIyMQcWs2p7DMgmmY1xdlxc1"}]}