{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360005520522194048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/gtc.12761"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fgtc.12761"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/gtc.12761"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/gtc.12761"}},{"identifier":{"@type":"PMID","@value":"32078200"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Maternal stress suppresses cell proliferation in the forebrain of zebrafish larvae"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Exposure to early life stress (ELS) can increase vulnerability to various psychiatric disorders. Although ELS has been shown to alter structure and functions of the hippocampus, amygdala and prefrontal cortex in the adult mammalian brain, it remains largely unclear whether ELS also affects embryonic or early‐stage brain development. In this study, I investigated the effects of a maternal stress (maternal starvation for 4 days) of adult zebrafish on offspring's larval brain development. Although maternal starvation did not largely affect proliferation rate in the midbrain and hindbrain, it significantly decreased that in the forebrain of larvae at 5 days post‐fertilization (dpf). I also found that embryos at 10 hr post‐fertilization (hpf) born from a starved mother showed elevated cortisol levels compared to those born from a control mother. Furthermore, cortisol treatment was sufficient to decrease proliferating cells in the forebrain of 5 dpf larvae. Our findings thus demonstrate for the first time that maternal starvation induces neurodevelopmental changes in the forebrain of zebrafish larvae and points to a possible role of maternal cortisol in mediating this effect of maternal stress to offsprings.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801207321728","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30420235"},{"@type":"NRID","@value":"1000030420235"},{"@type":"NRID","@value":"9000010689572"},{"@type":"NRID","@value":"9000000975656"},{"@type":"NRID","@value":"9000367417957"},{"@type":"NRID","@value":"9000255679551"},{"@type":"NRID","@value":"9000256022014"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/m_higuchi"}],"foaf:name":[{"@value":"Maiko Higuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Life Science Rikkyo University Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13569597"},{"@type":"EISSN","@value":"13652443"}],"prism:publicationName":[{"@value":"Genes to Cells"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2020-03-04","prism:volume":"25","prism:number":"5","prism:startingPage":"350","prism:endingPage":"357"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fgtc.12761"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/gtc.12761"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/gtc.12761"}],"createdAt":"2020-02-20","modifiedAt":"2023-09-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Stress,%20Physiological","dc:title":"Stress, 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