{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360009142829692672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15430/jcp.2020.25.4.204"}},{"identifier":{"@type":"URI","@value":"http://pdf.medrang.co.kr/Jkacp2/2020/025/JCP-25-204.pdf"}},{"identifier":{"@type":"PMID","@value":"33409253"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway"}],"description":[{"notation":[{"@value":"A transcription factor Sry-related high mobility group box (Sox) 17 is involved in developmental processes including spermatogenesis, cardiovascular system, endoderm formation, and so on. In this article, we firstly review the studies on the relation between the Sox17 expression and tumor malignancy. Although Sox17 positively promotes various tissue development, most of the cancers associated with Sox17 show decreased expression levels of Sox17, and an inverse correlation between Sox17 expression and malignancy is revealed. We briefly discuss the mechanism of such Sox17 down-regulation by focusing on DNA methylation of CpG sites located in the Sox17 gene promoter. Next, we overview the function of Sox17 in the fetal hematopoiesis, particularly in the dorsal aorta in midgestation mouse embryos. The Sox17 expression in hematopoietic stem cell (HSC)-containing intra-aortic hematopoietic cell cluster (IAHCs) is important for the cluster formation with the hematopoietic ability. The sustained expression of Sox17 in adult bone marrow HSCs and the cells in IAHCs of the dorsal aorta indicate abnormalities that are low lymphocyte chimerism and the aberrant proliferation of common myeloid progenitors in transplantation experiments. We then summarize the perspectives of Sox17 research in cancer control."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380009142829692673","@type":"Researcher","foaf:name":[{"@value":"Maha Anani"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751150490752","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40332879"},{"@type":"NRID","@value":"1000040332879"},{"@type":"NRID","@value":"9000001709348"},{"@type":"NRID","@value":"9000019090304"},{"@type":"NRID","@value":"9000261008348"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0068912"}],"foaf:name":[{"@value":"Ikuo Nobuhisa"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276173548032","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40192629"},{"@type":"NRID","@value":"1000040192629"},{"@type":"NRID","@value":"9000002741580"},{"@type":"NRID","@value":"9000413352873"},{"@type":"NRID","@value":"9000001829352"},{"@type":"NRID","@value":"9000000412277"},{"@type":"NRID","@value":"9000001738029"},{"@type":"NRID","@value":"9000010951788"},{"@type":"NRID","@value":"9000016755540"},{"@type":"NRID","@value":"9000019090306"},{"@type":"NRID","@value":"9000020445864"},{"@type":"NRID","@value":"9000253180574"},{"@type":"NRID","@value":"9000020556019"},{"@type":"NRID","@value":"9000409015954"},{"@type":"NRID","@value":"9000412363406"},{"@type":"NRID","@value":"9000253395896"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0068913"}],"foaf:name":[{"@value":"Tetsuya Taga"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"22883649"},{"@type":"EISSN","@value":"22883657"}],"prism:publicationName":[{"@value":"Journal of Cancer Prevention"}],"dc:publisher":[{"@value":"Korean Society of Cancer Prevention"}],"prism:publicationDate":"2020-12-30","prism:volume":"25","prism:number":"4","prism:startingPage":"204","prism:endingPage":"212"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0"],"url":[{"@id":"http://pdf.medrang.co.kr/Jkacp2/2020/025/JCP-25-204.pdf"}],"createdAt":"2020-12-31","modifiedAt":"2021-01-07","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781993350144","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02678"},{"@type":"JGN","@value":"JP18H02678"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02678/"}],"notation":[{"@language":"ja","@value":"生物機能性ポリマーアレイによる癌幹細胞ニッチの分子要素同定とシグナル経路の解明"},{"@language":"en","@value":"Elucidation of cancer stem cell niche components and signaling by bioactive polymer arrays"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781999545728","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K06249"},{"@type":"JGN","@value":"JP18K06249"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06249/"}],"notation":[{"@language":"ja","@value":"マウス胎生中期の大動脈血液細胞塊に生じる造血幹細胞の発生・成熟・維持機構の解明"},{"@language":"en","@value":"Elucidation of mechanisms for development, maturation, and maintenance in hematopoietic stem cells of intra-aortic hematopoietic cell clusters at midgestated mouse embryos"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232558231168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD45lowc-Kithigh cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232558418944","@type":"Article","resourceType":"学術雑誌論文(journal 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contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567758805248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568868477824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043430014720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin 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without the high mobility group box region, and their differential expression in mouse spermatogenesis."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521206821760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694368235560192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994020301824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994479977216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995107157632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phylogeny of the SOX Family of Developmental Transcription Factors Based on Sequence and Structural Indicators"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995125984896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995132757120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate 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Association with prognostic variables and survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945615496192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early endoderm development in vertebrates: lineage differentiation and morphogenetic function"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945747512832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Disruption of Endothelial Cell-selective Adhesion Molecule Inhibits Angiogenic Processes in Vitro and in Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946016171392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global Alterations of DNA Methylation in Cholangiocarcinoma Target the Wnt Signaling Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946391435136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SOX17 is a tumor suppressor in endometrial 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hematopoiesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420190563456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Sox17 as a Transcription Factor That Regulates Oligodendrocyte Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421341411584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893934839552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Redundant roles of<i>Sox17</i>and<i>Sox18</i>in postnatal angiogenesis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895333679232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hematopoietic stem cell development requires transient Wnt/β-catenin 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