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Kyoto probe-1 reveals phenotypic differences between mouse ES cells and iTS-P cells
Description
<jats:title>Abstract</jats:title><jats:p>Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneously transplanting them into immunodeficient mice did not generate teratomas. In this study, we applied KP-1 to analyze mouse ES (mES) cells and mouse iTS-P (miTS-P) cells. KP-1 completely stained mES cells in colonies, but only miTS-P cells at the edge of a colony. This difference was caused by cell type-specific expression of different ABC transporters. These finding suggest that KP-1 will be useful for distinguishing between iPS and iTS-P cells.</jats:p>
Journal
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- Scientific Reports
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Scientific Reports 10 (1), 18084-, 2020-10-22
Springer Science and Business Media LLC
