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They also directly stimulate tumor cell proliferation, metastasis, and angiogenesis. In ovarian cancer, there are increased numbers of circulating or tumor-infiltrating MDSCs, and increased frequencies of MDSCs are associated with a poor prognosis or an advanced clinical stage. Moreover, in murine models of ovarian cancer, MDSC depletion has shown significant growth-inhibitory effects and enhanced the therapeutic efficacy of existing anticancer therapies. In this review, we summarize the current knowledge on MDSC biology, clinical significance of MDSC, and potential MDSC-targeting strategies in ovarian cancer.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276158556160","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00452441"},{"@type":"NRID","@value":"1000000452441"},{"@type":"NRID","@value":"9000364447657"},{"@type":"NRID","@value":"9000364518272"},{"@type":"NRID","@value":"9000364277024"},{"@type":"NRID","@value":"9000364274235"},{"@type":"NRID","@value":"9000364535226"},{"@type":"NRID","@value":"9000364510773"},{"@type":"NRID","@value":"9000364458980"},{"@type":"NRID","@value":"9000364579382"},{"@type":"NRID","@value":"9000365518058"},{"@type":"NRID","@value":"9000364548493"},{"@type":"NRID","@value":"9000402823329"},{"@type":"NRID","@value":"9000019114192"},{"@type":"NRID","@value":"9000369330201"},{"@type":"NRID","@value":"9000364308134"},{"@type":"NRID","@value":"9000364330650"},{"@type":"NRID","@value":"9000364500526"},{"@type":"NRID","@value":"9000364405449"},{"@type":"NRID","@value":"9000364511067"},{"@type":"NRID","@value":"9000364535214"},{"@type":"NRID","@value":"9000364529749"},{"@type":"NRID","@value":"9000364568126"},{"@type":"NRID","@value":"9000364304983"},{"@type":"NRID","@value":"9000364568250"},{"@type":"NRID","@value":"9000364326097"},{"@type":"NRID","@value":"9000364410068"},{"@type":"NRID","@value":"9000364518297"},{"@type":"NRID","@value":"9000364560483"},{"@type":"NRID","@value":"9000364408334"},{"@type":"NRID","@value":"9000364413922"},{"@type":"NRID","@value":"9000364434146"},{"@type":"NRID","@value":"9000364323587"},{"@type":"NRID","@value":"9000364580381"},{"@type":"NRID","@value":"9000364534694"},{"@type":"NRID","@value":"9000364555328"},{"@type":"NRID","@value":"9000364580654"},{"@type":"NRID","@value":"9000364465142"},{"@type":"NRID","@value":"9000364581279"},{"@type":"NRID","@value":"9000364582626"},{"@type":"NRID","@value":"9000364434994"},{"@type":"NRID","@value":"9000364494222"},{"@type":"NRID","@value":"9000364540984"},{"@type":"NRID","@value":"9000403049638"},{"@type":"NRID","@value":"9000364582682"},{"@type":"NRID","@value":"9000394954456"},{"@type":"NRID","@value":"9000364393970"},{"@type":"NRID","@value":"9000364581291"},{"@type":"NRID","@value":"9000364494204"},{"@type":"NRID","@value":"9000364535410"},{"@type":"NRID","@value":"9000364541553"},{"@type":"NRID","@value":"9000359873192"},{"@type":"NRID","@value":"9000364463818"},{"@type":"NRID","@value":"9000364459146"},{"@type":"NRID","@value":"9000364501433"},{"@type":"NRID","@value":"9000364510929"},{"@type":"NRID","@value":"9000364536309"},{"@type":"NRID","@value":"9000364525584"},{"@type":"NRID","@value":"9000396185382"}],"foaf:name":[{"@value":"Seiji Mabuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Obstetrics and Gynecology, Nara Medical University, Nara 634-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380009142908807041","@type":"Researcher","foaf:name":[{"@value":"Tomoyuki Sasano"}],"jpcoar:affiliationName":[{"@value":"Department of Obstetrics and Gynecology, Osaka Saiseikai Nakatsu Hospital, Osaka 530-0012, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380009142908806913","@type":"Researcher","foaf:name":[{"@value":"Naoko Komura"}],"jpcoar:affiliationName":[{"@value":"Department of Obstetrics and Gynecology, Kaizuka City Hospital, Osaka 597-0015, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20734409"}],"prism:publicationName":[{"@value":"Cells"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2021-02-05","prism:volume":"10","prism:number":"2","prism:startingPage":"329"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2073-4409/10/2/329/pdf"}],"createdAt":"2021-02-05","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Ovarian%20Neoplasms","dc:title":"Ovarian Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=QH573-671","dc:title":"QH573-671"},{"@id":"https://cir.nii.ac.jp/all?q=Myeloid-Derived%20Suppressor%20Cells","dc:title":"Myeloid-Derived Suppressor Cells"},{"@id":"https://cir.nii.ac.jp/all?q=MDSC","dc:title":"MDSC"},{"@id":"https://cir.nii.ac.jp/all?q=therapeutic%20target","dc:title":"therapeutic target"},{"@id":"https://cir.nii.ac.jp/all?q=survival","dc:title":"survival"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Analysis","dc:title":"Survival 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