{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011143909058048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1101/gad.309625.117"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/gad.309625.117"}}],"dc:title":[{"@value":"Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in <i>C. elegans</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is achieved, however, is poorly understood. Here, using <jats:italic>Caenorhabditis elegans</jats:italic> as a model, we identified two distinct neuroendocrine signaling circuits by which the worm nervous system senses cool and warm environmental temperatures through cool- and warm-sensitive neurons and then signals the gut to extend and shorten life span, respectively. The prolongevity “cool” circuit uses the small neurotransmitters glutamate and serotonin, whereas the anti-longevity “warm” circuit is mediated by insulin-like neuropeptides. Both types of neuroendocrine signals converge on the gut through their cognate receptors to differentially regulate the transcription factor DAF-16/FOXO, leading to opposing outcomes in longevity. Our study illustrates how the brain detects and processes environmental signals to bidirectionally regulate longevity by signaling the gut.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011143909058052","@type":"Researcher","foaf:name":[{"@value":"Bi Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011143909058048","@type":"Researcher","foaf:name":[{"@value":"Jianke Gong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011143909058051","@type":"Researcher","foaf:name":[{"@value":"Wenyuan Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011143909058053","@type":"Researcher","foaf:name":[{"@value":"Rui Xiao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011143909058049","@type":"Researcher","foaf:name":[{"@value":"Jianfeng Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011143909058050","@type":"Researcher","foaf:name":[{"@value":"X.Z. Shawn Xu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08909369"},{"@type":"EISSN","@value":"15495477"}],"prism:publicationName":[{"@value":"Genes & Development"}],"dc:publisher":[{"@value":"Cold Spring Harbor Laboratory"}],"prism:publicationDate":"2018-02-01","prism:volume":"32","prism:number":"3-4","prism:startingPage":"258","prism:endingPage":"270"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1101/gad.309625.117"}],"createdAt":"2018-02-28","modifiedAt":"2021-11-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360022305560493952","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increasing glucose uptake into neurons antagonizes brain aging and promotes health and life span under dietary restriction in\n                  <i>Drosophila</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617865083648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302471622275072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temperature Acclimation and Cold Tolerance in Caenorhabditis Elegans are Regulated by Multiorgan Coordination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302474875641856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temperature acclimation: Temperature shift induces system conversion to cold tolerance in C. elegans"}]},{"@id":"https://cir.nii.ac.jp/crid/1390291767614424832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular physiology regulating cold tolerance and acclimation of <i>Caenorhabditis elegans</i>"},{"@value":"Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1101/gad.309625.117"},{"@type":"CROSSREF","@value":"10.1101/2020.06.11.145227_references_DOI_CfGIGWO13wBi5cvEaJf5HTBLfBx"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2020.101979_references_DOI_CfGIGWO13wBi5cvEaJf5HTBLfBx"},{"@type":"CROSSREF","@value":"10.2108/zs240029_references_DOI_CfGIGWO13wBi5cvEaJf5HTBLfBx"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2023.04.005_references_DOI_CfGIGWO13wBi5cvEaJf5HTBLfBx"},{"@type":"CROSSREF","@value":"10.2183/pjab.98.009_references_DOI_CfGIGWO13wBi5cvEaJf5HTBLfBx"}]}