{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011144058598656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0703650104"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0703650104"}},{"identifier":{"@type":"PMID","@value":"17699617"}},{"identifier":{"@type":"HANDLE","@value":"2434/43339"}}],"dc:title":[{"@value":"Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Membrane microdomains (lipid rafts) are now recognized as critical for proper compartmentalization of insulin signaling. We previously demonstrated that, in adipocytes in a state of TNFα-induced insulin resistance, the inhibition of insulin metabolic signaling and the elimination of insulin receptors (IR) from the caveolae microdomains were associated with an accumulation of the ganglioside GM3. To gain insight into molecular mechanisms behind interactions of IR, caveolin-1 (Cav1), and GM3 in adipocytes, we have performed immunoprecipitations, cross-linking studies of IR and GM3, and live cell studies using total internal reflection fluorescence microscopy and fluorescence recovery after photobleaching techniques. We found that (\n            <jats:italic>i</jats:italic>\n            ) IR form complexes with Cav1 and GM3 independently; (\n            <jats:italic>ii</jats:italic>\n            ) in GM3-enriched membranes the mobility of IR is increased by dissociation of the IR–Cav1 interaction; and (\n            <jats:italic>iii</jats:italic>\n            ) the lysine residue localized just above the transmembrane domain of the IR β-subunit is essential for the interaction of IR with GM3. Because insulin metabolic signal transduction in adipocytes is known to be critically dependent on caveolae, we propose a pathological feature of insulin resistance in adipocytes caused by dissociation of the IR–Cav1 complex by the interactions of IR with GM3 in microdomains.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380576121112169991","@type":"Researcher","foaf:name":[{"@value":"Kazuya Kabayama"}],"jpcoar:affiliationName":[{"@value":"*Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Miyagi, Japan;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169989","@type":"Researcher","foaf:name":[{"@value":"Takashige Sato"}],"jpcoar:affiliationName":[{"@value":"Department of Biomembrane and Biofunctional Chemistry, School of Pharmaceutical Sciences and Pharmacy, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169990","@type":"Researcher","foaf:name":[{"@value":"Kumiko Saito"}],"jpcoar:affiliationName":[{"@value":"Department of Biomembrane and Biofunctional Chemistry, School of Pharmaceutical Sciences and Pharmacy, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169986","@type":"Researcher","foaf:name":[{"@value":"Nicoletta Loberto"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Via Fratelli Cervi 93, Segrate 20090, Milan, Italy; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169992","@type":"Researcher","foaf:name":[{"@value":"Alessandro Prinetti"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Via Fratelli Cervi 93, Segrate 20090, Milan, Italy; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169985","@type":"Researcher","foaf:name":[{"@value":"Sandro Sonnino"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Via Fratelli Cervi 93, Segrate 20090, Milan, Italy; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169988","@type":"Researcher","foaf:name":[{"@value":"Masataka Kinjo"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Supramolecular Biophysics, Research Institute for Electronic Science, Hokkaido University, Nishi 6, Kita 12, Kita-ku, Sapporo 060-0812, Japan;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169984","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Igarashi"}],"jpcoar:affiliationName":[{"@value":"Department of Biomembrane and Biofunctional Chemistry, School of Pharmaceutical Sciences and Pharmacy, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576121112169987","@type":"Researcher","foaf:name":[{"@value":"Jin-ichi Inokuchi"}],"jpcoar:affiliationName":[{"@value":"*Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Miyagi, Japan;"},{"@value":"Core Research for Evolutional Science and Technology Program, Japan Science and Technology Agency, 4-1-8, Honcho Kawaguchi, Saitama 332-0012, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00278424"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2007-08-21","prism:volume":"104","prism:number":"34","prism:startingPage":"13678","prism:endingPage":"13683"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0703650104"}],"createdAt":"2007-08-16","modifiedAt":"2022-04-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Survival","dc:title":"Cell Survival"},{"@id":"https://cir.nii.ac.jp/all?q=Lysine","dc:title":"Lysine"},{"@id":"https://cir.nii.ac.jp/all?q=Caveolin%201","dc:title":"Caveolin 1"},{"@id":"https://cir.nii.ac.jp/all?q=Adipocyte;%20Caveolae%20microdomain;%20Lipid%20rafts;%20Live%20cell%20imaging;%20Type%202%20diabetes","dc:title":"Adipocyte; Caveolae microdomain; Lipid rafts; Live cell imaging; Type 2 diabetes"},{"@id":"https://cir.nii.ac.jp/all?q=Receptor,%20Insulin","dc:title":"Receptor, Insulin"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=3T3-L1%20Cells","dc:title":"3T3-L1 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=G(M3)%20Ganglioside","dc:title":"G(M3) Ganglioside"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin%20Resistance","dc:title":"Insulin Resistance"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050299306989124352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dynamic assembly and interaction of glycosphingolipids in cholesterol-containing model membranes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215418518784","@type":"Article","resourceType":"学術雑誌論文(journal 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