{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011144330207232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/nbt.3802"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nbt.3802.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nbt.3802"}}],"dc:title":[{"@value":"Overcoming cellular barriers for RNA therapeutics"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011144330207232","@type":"Researcher","foaf:name":[{"@value":"Steven F Dowdy"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10870156"},{"@type":"EISSN","@value":"15461696"}],"prism:publicationName":[{"@value":"Nature Biotechnology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-02-27","prism:volume":"35","prism:number":"3","prism:startingPage":"222","prism:endingPage":"229"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm","http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/nbt.3802.pdf"},{"@id":"http://www.nature.com/articles/nbt.3802"}],"createdAt":"2017-02-28","modifiedAt":"2023-05-18","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050859073010978176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use of homoarginine to obtain attenuated cationic membrane lytic peptides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142435075072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RNA and Oxidative Stress in Alzheimer’s Disease: Focus on microRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168837281280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antisense Oligonucleotide Modified with Disulfide Units Induces Efficient Exon Skipping in <i>mdx</i> Myotubes through Enhanced Membrane Permeability and Nucleus Internalization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282226391552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antitumoral <scp>RNA</scp>‐targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390756565888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286994165123328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of modular conjugation strategy for<i>N</i>-acetylgalactosamine-targeted antisense oligonucleotides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617877681152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Virus-Mimicking Nanocarriers for The Intracellular Delivery of Therapeutic Biomolecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643767264128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"siRNA Vehicles for High Endosomal Escapability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643846369408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Solid-phase synthesis of oligouridine boranophosphates using the H-boranophosphonate method with 2′-O-(2-cyanoethoxymethyl) protection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179880200960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182212651008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092853075584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cytoplasmic delivery of small interfering RNA by photoresponsive non-cationic liposomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232402418688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380606976896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658069853568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inducible Membrane Permeabilization by Attenuated Lytic Peptides: A New Concept for Accessing Cell Interiors through Ruffled Membranes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815680391296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815695685248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390003825180194560","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Disulfide-unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA"},{"@language":"ja","@value":"ジスルフィド修飾によるオリゴ核酸の超高速細胞質移行"},{"@language":"ja-Kana","@value":"ジスルフィド シュウショク ニ ヨル オリゴ カクサン ノ チョウコウソク サイボウシツ イコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390283659848432640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units"},{"@value":"Communication to the Editor : Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units"}]},{"@id":"https://cir.nii.ac.jp/crid/1390569302468217088","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of Oligonucleotide Therapeutics: Tissue Distribution and Drug Delivery Systems"},{"@language":"ja","@value":"核酸医薬品開発における体内動態とDDS"},{"@language":"ja-Kana","@value":"カクサン イヤクヒン カイハツ ニ オケル タイナイ ドウタイ ト DDS"}]},{"@id":"https://cir.nii.ac.jp/crid/1390580063061900544","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of targeted siRNA delivery technologies by saccharide ligand conjugates"},{"@language":"ja","@value":"糖鎖リガンドによるsiRNAのデリバリー技術の開発"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/nbt.3802"},{"@type":"CROSSREF","@value":"10.1155/2020/2638130_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2021.127925_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1002/cbic.202100413_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1111/cas.15461_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1089/nat.2022.0054_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1080/15257770.2019.1677911_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1021/acs.molpharmaceut.9b00156_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.2745/dds.36.40_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.2217/nnm-2020-0078_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1007/978-1-0716-1298-9_11_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1016/j.tetlet.2021.153526_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1002/anie.201900993_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1016/j.jddst.2021.102488_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.2745/dds.38.313_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1186/s12951-022-01667-4_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1002/advs.202407619_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1002/anie.202317817_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1021/acschembio.3c00612_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1248/cpb.c19-00811_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.1016/j.jconrel.2018.12.044_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.78.456_references_DOI_3HF1CaIV1Qebdht8cH8YVbOPisM"}]}