{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011144864276992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1096/fj.07-9591com"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.07-9591com"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.07-9591com"}},{"identifier":{"@type":"URI","@value":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.07-9591com"}},{"identifier":{"@type":"PMID","@value":"18070821"}}],"dc:title":[{"@value":"The taste transduction channel TRPM5 is a locus for bitter‐sweet taste interactions"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Ordinary gustatory experiences, which are usually evoked by taste mixtures, are determined by multiple interactions between different taste stimuli. The most studied model for these gustatory interactions is the suppression of the responses to sweeteners by the prototype bitter compound quinine. Here we report that TRPM5, a cation channel involved in sweet taste transduction, is inhibited by quinine (EC\n                    <jats:sub>50</jats:sub>\n                    =50 μM at —50 mV) owing to a decrease in the maximal whole‐cell TRPM5 conductance and an acceleration of channel closure. Notably, quinine inhibits the gustatory responses of sweet‐sensitive gustatory nerves in wild type (EC\n                    <jats:sub>50</jats:sub>\n                    =§1.6 mM) but not in\n                    <jats:italic>Trpm5</jats:italic>\n                    knockout mice. Quinine induces a dose‐ and time‐dependent inhibition of TRPM5‐dependent responses of single sweet‐sensitive fibers to sucrose, according to the re stricted diffusion of the drug into the taste tissue. Quinidine, the stereoisomer of quinine, has similar effects on TRPM5 currents and on sweet‐induced gus tatory responses. In contrast, the chemically unrelated bitter compound denatonium benzoate has an § 100 fold weaker effect on TRPM5 currents and, accord ingly, at 10 mM it does not alter gustatory responses to sucrose. The inhibition of TRPM5 by bitter compounds constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway.—Talavera, K., Yasumatsu, K., Yoshida, R., Margolskee, R. F., Voets, T., Ninomiya, Y., Nilius, B. The taste transduction channel TRPM5 is a locus for bitter‐sweet taste inter actions. FASEBJ. 22, 1343–1355 (2008)\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011144864276993","@type":"Researcher","foaf:name":[{"@value":"Karel Talavera"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Ion Channel Research Department of Molecular Cell Biology KU Leuven Leuven Belgium"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751140658048","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50380704"},{"@type":"NRID","@value":"1000050380704"},{"@type":"NRID","@value":"9000347075708"},{"@type":"NRID","@value":"9000006811840"},{"@type":"NRID","@value":"9000412250314"},{"@type":"NRID","@value":"9000255839457"},{"@type":"NRID","@value":"9000003003946"},{"@type":"NRID","@value":"9000415045171"},{"@type":"NRID","@value":"9000347064878"},{"@type":"NRID","@value":"9000347067809"},{"@type":"NRID","@value":"9000347072248"},{"@type":"NRID","@value":"9000392135290"},{"@type":"NRID","@value":"9000392138232"},{"@type":"NRID","@value":"9000003081647"},{"@type":"NRID","@value":"9000347459918"},{"@type":"NRID","@value":"9000006866640"},{"@type":"NRID","@value":"9000257188392"},{"@type":"NRID","@value":"9000250758394"},{"@type":"NRID","@value":"9000347070682"},{"@type":"NRID","@value":"9000347069729"},{"@type":"NRID","@value":"9000392136688"},{"@type":"NRID","@value":"9000000986559"},{"@type":"NRID","@value":"9000347072255"},{"@type":"NRID","@value":"9000412550196"},{"@type":"NRID","@value":"9000409028993"},{"@type":"NRID","@value":"9000347071462"},{"@type":"NRID","@value":"9000023340207"},{"@type":"NRID","@value":"9000313620737"},{"@type":"NRID","@value":"9000363297162"},{"@type":"NRID","@value":"9000411546821"},{"@type":"NRID","@value":"9000347072106"},{"@type":"NRID","@value":"9000257888659"},{"@type":"NRID","@value":"9000392135827"},{"@type":"NRID","@value":"9000018456859"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0060355"}],"foaf:name":[{"@value":"Keiko Yasumatsu"}],"jpcoar:affiliationName":[{"@value":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276187267584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60380705"},{"@type":"NRID","@value":"1000060380705"},{"@type":"NRID","@value":"9000347076097"},{"@type":"NRID","@value":"9000252868142"},{"@type":"NRID","@value":"9000347075758"},{"@type":"NRID","@value":"9000272989556"},{"@type":"NRID","@value":"9000412274475"},{"@type":"NRID","@value":"9000413332199"},{"@type":"NRID","@value":"9000347070677"},{"@type":"NRID","@value":"9000415045170"},{"@type":"NRID","@value":"9000347064879"},{"@type":"NRID","@value":"9000347067807"},{"@type":"NRID","@value":"9000347072249"},{"@type":"NRID","@value":"9000392135291"},{"@type":"NRID","@value":"9000392138231"},{"@type":"NRID","@value":"9000002735012"},{"@type":"NRID","@value":"9000006866639"},{"@type":"NRID","@value":"9000347070680"},{"@type":"NRID","@value":"9000409990191"},{"@type":"NRID","@value":"9000392136690"},{"@type":"NRID","@value":"9000257942741"},{"@type":"NRID","@value":"9000317144692"},{"@type":"NRID","@value":"9000347067610"},{"@type":"NRID","@value":"9000347072253"},{"@type":"NRID","@value":"9000283272587"},{"@type":"NRID","@value":"9000347065055"},{"@type":"NRID","@value":"9000021098157"},{"@type":"NRID","@value":"9000347072112"},{"@type":"NRID","@value":"9000414842358"},{"@type":"NRID","@value":"9000409204515"},{"@type":"NRID","@value":"9000347072107"},{"@type":"NRID","@value":"9000257888658"},{"@type":"NRID","@value":"9000392135826"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/RYTCP"}],"foaf:name":[{"@value":"Ryusuke Yoshida"}],"jpcoar:affiliationName":[{"@value":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011144864276995","@type":"Researcher","foaf:name":[{"@value":"Robert F. 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Ninomiya"}],"jpcoar:affiliationName":[{"@value":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011144864276997","@type":"Researcher","foaf:name":[{"@value":"Bernd Nilius"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Ion Channel Research Department of Molecular Cell Biology KU Leuven Leuven Belgium"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08926638"},{"@type":"EISSN","@value":"15306860"}],"prism:publicationName":[{"@value":"The FASEB Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2007-12-10","prism:volume":"22","prism:number":"5","prism:startingPage":"1343","prism:endingPage":"1355"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.07-9591com"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.07-9591com"},{"@id":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.07-9591com"}],"createdAt":"2007-12-10","modifiedAt":"2025-10-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=signal-transduction","dc:title":"signal-transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Sucrose","dc:title":"Sucrose"},{"@id":"https://cir.nii.ac.jp/all?q=Patch-Clamp%20Techniques","dc:title":"Patch-Clamp Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=taste%20mixture","dc:title":"taste mixture"},{"@id":"https://cir.nii.ac.jp/all?q=TRPM%20Cation%20Channels","dc:title":"TRPM Cation Channels"},{"@id":"https://cir.nii.ac.jp/all?q=sensary%20interaction","dc:title":"sensary interaction"},{"@id":"https://cir.nii.ac.jp/all?q=mixture%20interactions","dc:title":"mixture interactions"},{"@id":"https://cir.nii.ac.jp/all?q=gustatory%20nerve","dc:title":"gustatory nerve"},{"@id":"https://cir.nii.ac.jp/all?q=stimuli","dc:title":"stimuli"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=quinine","dc:title":"quinine"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=rapid%20entry","dc:title":"rapid entry"},{"@id":"https://cir.nii.ac.jp/all?q=Quinine","dc:title":"Quinine"},{"@id":"https://cir.nii.ac.jp/all?q=receptor-cells","dc:title":"receptor-cells"},{"@id":"https://cir.nii.ac.jp/all?q=Electric%20Conductivity","dc:title":"Electric Conductivity"},{"@id":"https://cir.nii.ac.jp/all?q=suppression","dc:title":"suppression"},{"@id":"https://cir.nii.ac.jp/all?q=Quinidine","dc:title":"Quinidine"},{"@id":"https://cir.nii.ac.jp/all?q=Quaternary%20Ammonium%20Compounds","dc:title":"Quaternary Ammonium Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Taste","dc:title":"Taste"},{"@id":"https://cir.nii.ac.jp/all?q=ion-channel","dc:title":"ion-channel"},{"@id":"https://cir.nii.ac.jp/all?q=responses","dc:title":"responses"},{"@id":"https://cir.nii.ac.jp/all?q=chorda%20tympani%20nerve","dc:title":"chorda tympani nerve"},{"@id":"https://cir.nii.ac.jp/all?q=nonselective%20cation%20channel","dc:title":"nonselective cation channel"},{"@id":"https://cir.nii.ac.jp/all?q=Chorda%20Tympani%20Nerve","dc:title":"Chorda Tympani Nerve"},{"@id":"https://cir.nii.ac.jp/all?q=Ion%20Channel%20Gating","dc:title":"Ion Channel Gating"},{"@id":"https://cir.nii.ac.jp/all?q=quinidine","dc:title":"quinidine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218140735360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression levels of taste‐related genes in palate and tongue tip, and involvement of transient receptor potential subfamily M member 5 (<scp>TRPM</scp>5) in taste sense in chickens"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708633958144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Taste information derived from T1R-expressing taste cells in 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