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Dissecting cellular components of the secretory pathway in filamentous fungi: insights into their application for protein production
Bibliographic Information
- Published
- 2007-09-11
- Rights Information
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- http://www.springer.com/tdm
- DOI
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- 10.1007/s10529-007-9516-1
- Publisher
- Springer Science and Business Media LLC
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Description
Studies on protein production using filamentous fungi have mostly focused on improvement of the protein yields by genetic modifications such as overexpression. Recent genome sequencing in several filamentous fungal species now enables more systematic approaches based on reverse genetics and molecular biology of the secretion pathway. In this review, we summarize recent molecular-based advances in our understanding of vesicular trafficking in filamentous fungi, and discuss insights into their high secretion ability and application for protein production.
Journal
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- Biotechnology Letters
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Biotechnology Letters 30 (1), 7-14, 2007-09-11
Springer Science and Business Media LLC
