{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011145990022016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.cir.96.5.1432"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.96.5.1432"}}],"dc:title":[{"@value":"Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction"}],"dcterms:alternative":[{"@value":"The Rotterdam Study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            <jats:italic>Background</jats:italic>\n            Noninvasive assessment of intima-media thickness (IMT) is widely used in observational studies and trials as an intermediate or proxy end point for cardiovascular disease. However, data showing that IMT predicts cardiovascular disease are limited. We studied whether common carotid IMT is related to future stroke and myocardial infarction.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results</jats:italic>\n            We used a nested case-control approach among 7983 subjects aged ≥55 years participating in the Rotterdam Study. At baseline (March 1990 through July 1993), ultrasound images of the common carotid artery were stored on videotape. Determination of incident myocardial infarction and stroke was predominantly based on hospital discharge records. Analysis (logistic regression) was based on 98 myocardial infarctions and 95 strokes that were registered before December 31, 1994. IMT was measured from videotape for all case subjects and a sample of 1373 subjects who remained free from myocardial infarction and stroke during follow-up. The mean duration of follow-up was 2.7 years. Results were adjusted for age and sex. Stroke risk increased gradually with increasing IMT. The odds ratio for stroke per standard deviation increase (0.163 mm) was 1.41 (95% CI, 1.25 to 1.82). For myocardial infarction, an odds ratio of 1.43 (95% CI, 1.16 to 1.78) was found. When subjects with a previous myocardial infarction or stroke were excluded, odds ratios were 1.57 (95% CI, 1.27 to 1.94) for stroke and 1.51 (95% CI, 1.18 to 1.92) for myocardial infarction. Additional adjustment for several cardiovascular risk factors attenuated these associations: 1.34 (95% CI, 1.08 to 1.67) and 1.25 (95% CI, 0.98 to 1.58), respectively.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Conclusions</jats:italic>\n            The present study, based on a short follow-up period, provides evidence that an increased common carotid IMT is associated with future cerebrovascular and cardiovascular events.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011145990022019","@type":"Researcher","foaf:name":[{"@value":"Michiel L. Bots"}],"jpcoar:affiliationName":[{"@value":"From the Department of Epidemiology and Biostatistics (M.L.B., A.W.H., A.H., D.E.G.) and Department of General Practice (A.W.H.), Erasmus University Medical School, Rotterdam, Netherlands; Julius Center of Patient Oriented Research (M.L.B., A.W.H., D.E.G.), Utrecht University, Netherlands; and Department of Neurology (P.J.K.), University Hospital Rotterdam, The Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1380011145990022017","@type":"Researcher","foaf:name":[{"@value":"Arno W. Hoes"}],"jpcoar:affiliationName":[{"@value":"From the Department of Epidemiology and Biostatistics (M.L.B., A.W.H., A.H., D.E.G.) and Department of General Practice (A.W.H.), Erasmus University Medical School, Rotterdam, Netherlands; Julius Center of Patient Oriented Research (M.L.B., A.W.H., D.E.G.), Utrecht University, Netherlands; and Department of Neurology (P.J.K.), University Hospital Rotterdam, The Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1380011145990022016","@type":"Researcher","foaf:name":[{"@value":"Peter J. Koudstaal"}],"jpcoar:affiliationName":[{"@value":"From the Department of Epidemiology and Biostatistics (M.L.B., A.W.H., A.H., D.E.G.) and Department of General Practice (A.W.H.), Erasmus University Medical School, Rotterdam, Netherlands; Julius Center of Patient Oriented Research (M.L.B., A.W.H., D.E.G.), Utrecht University, Netherlands; and Department of Neurology (P.J.K.), University Hospital Rotterdam, The Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1380011145990022018","@type":"Researcher","foaf:name":[{"@value":"Albert Hofman"}],"jpcoar:affiliationName":[{"@value":"From the Department of Epidemiology and Biostatistics (M.L.B., A.W.H., A.H., D.E.G.) and Department of General Practice (A.W.H.), Erasmus University Medical School, Rotterdam, Netherlands; Julius Center of Patient Oriented Research (M.L.B., A.W.H., D.E.G.), Utrecht University, Netherlands; and Department of Neurology (P.J.K.), University Hospital Rotterdam, The Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1380011145990022020","@type":"Researcher","foaf:name":[{"@value":"Diederick E. Grobbee"}],"jpcoar:affiliationName":[{"@value":"From the Department of Epidemiology and Biostatistics (M.L.B., A.W.H., A.H., D.E.G.) and Department of General Practice (A.W.H.), Erasmus University Medical School, Rotterdam, Netherlands; Julius Center of Patient Oriented Research (M.L.B., A.W.H., D.E.G.), Utrecht University, Netherlands; and Department of Neurology (P.J.K.), University Hospital Rotterdam, The Netherlands."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00097322"},{"@type":"EISSN","@value":"15244539"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00097322"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00097322"}],"prism:publicationName":[{"@value":"Circulation"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"1997-09-02","prism:volume":"96","prism:number":"5","prism:startingPage":"1432","prism:endingPage":"1437"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.96.5.1432"}],"createdAt":"2012-06-12","modifiedAt":"2024-05-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677860361728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serum cystatin C level is associated with carotid arterial wall elasticity in subjects with type 2 diabetes mellitus: A potential marker of early-stage atherosclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050850247228660480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands 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超音波エコー法による頸動脈病変の評価"},{"@language":"en","@value":"Ultrasonographic Evaluation of Carotid Atherosclerosis as a Surrogate Marker for Cardiovascular Events"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204421431552","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Arterial Aging from a Gerontological Viewpoint"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204430656768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Echolucent Carotid Plaque is Associated with Future Renal Dysfunction in Patients with Stable Coronary Artery Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204431141120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Associations of Cardiovascular Risk Factors with Carotid Intima-Media Thickness in Middle-Age Adults and 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therapy as a possible risk factor for atherosclerosis in end-stage renal disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206299688704","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Serum DHEA-S Level Is Associated with the Presence of Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206300093056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regression of the Increased Common Carotid Artery-intima Media Thickness in Subclinical Hypothyroidism after Thyroid Hormone Replacement"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288065059200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Screening Validity of Arterial Pressure–Volume Index and Arterial Velocity–Pulse Index for Preclinical Atherosclerosis in Japanese Community-Dwelling Adults: the Nagasaki Islands Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288138944768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Prediction of Atherosclerosis　― Significance of Polymorphisms in Bone Morphogenetic Protein Signaling Molecule Genes ―"},{"@value":"Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness"},{"@value":"Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (<i>BMPR1B</i>) Gene Are Predictive for Carotid Intima-Media Thickness"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288155824896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an 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