{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011146166577664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/jm990014j"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/jm990014j"}},{"identifier":{"@type":"PMID","@value":"10411480"}}],"dc:title":[{"@value":"Synthesis and Antimalarial Activity of Cyclic Peroxides, 1,2,4,5,7-Pentoxocanes and 1,2,4,5-Tetroxanes"}],"description":[{"notation":[{"@value":"A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011146166577538","@type":"Researcher","foaf:name":[{"@value":"Hye-Sook Kim"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146166577537","@type":"Researcher","foaf:name":[{"@value":"Yasuharu Shibata"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146166577536","@type":"Researcher","foaf:name":[{"@value":"Yusuke Wataya"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146166577664","@type":"Researcher","foaf:name":[{"@value":"Kaoru Tsuchiya"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146166577539","@type":"Researcher","foaf:name":[{"@value":"Araki Masuyama"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146166577540","@type":"Researcher","foaf:name":[{"@value":"Masatomo Nojima"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00222623"},{"@type":"EISSN","@value":"15204804"}],"prism:publicationName":[{"@value":"Journal of Medicinal Chemistry"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"1999-06-29","prism:volume":"42","prism:number":"14","prism:startingPage":"2604","prism:endingPage":"2609"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/jm990014j"}],"createdAt":"2002-07-26","modifiedAt":"2023-03-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20ICR","dc:title":"Mice, Inbred 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