{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360011146432005120.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bioorg.2019.103285"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0045206819311034?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0045206819311034?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31561103"}}],"dc:title":[{"@value":"2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors"}],"description":[{"notation":[{"@value":"A series of eighteen 2-styrylchromone derivatives (see Chart 1) were synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibitory activities. Many of the derivatives inhibited MAO-B comparable to pargyline (a positive control), and most of them inhibited MAO-B selectively. Of the eighteen derivatives, compound 9 having methoxy group at R"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380011146432005248","@type":"Researcher","foaf:name":[{"@value":"Koichi Takao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146432005123","@type":"Researcher","foaf:name":[{"@value":"Saki Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326222235904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50828142"},{"@type":"NRID","@value":"1000050828142"},{"@type":"NRID","@value":"9000283603411"},{"@type":"NRID","@value":"9000406033046"},{"@type":"NRID","@value":"9000410152151"},{"@type":"NRID","@value":"9000408482921"},{"@type":"NRID","@value":"9000409203645"},{"@type":"NRID","@value":"9000411501150"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nagaijunko"}],"foaf:name":[{"@value":"Junko Nagai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146432005124","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Kamauchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146432005121","@type":"Researcher","foaf:name":[{"@value":"Yuri Takemura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146432005122","@type":"Researcher","foaf:name":[{"@value":"Yoshihiro Uesawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380011146432005125","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki Sugita"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00452068"}],"prism:publicationName":[{"@value":"Bioorganic Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-11","prism:volume":"92","prism:startingPage":"103285"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0045206819311034?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0045206819311034?httpAccept=text/plain"}],"createdAt":"2019-09-18","modifiedAt":"2025-09-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Monoamine%20Oxidase%20Inhibitors","dc:title":"Monoamine Oxidase Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Structure","dc:title":"Molecular Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Chromones","dc:title":"Chromones"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Quantitative%20Structure-Activity%20Relationship","dc:title":"Quantitative Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Monoamine%20Oxidase","dc:title":"Monoamine Oxidase"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Proteins","dc:title":"Recombinant Proteins"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142921476224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092874897280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1391975276373157120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Syntheses and Evaluation of 2- or 3-(<i>N</i>-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors"},{"@value":"Syntheses and Evaluation of 2- or 3-(N-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bioorg.2019.103285"},{"@type":"OPENAIRE","@value":"doi_dedup___::0bfcdd34aac988d276d6ffbae1ce58d9"},{"@type":"CROSSREF","@value":"10.3390/medicines7090050_references_DOI_SLo9GclPQq8i16Um290RuqAWCHm"},{"@type":"CROSSREF","@value":"10.1248/cpb.c20-00579_references_DOI_SLo9GclPQq8i16Um290RuqAWCHm"},{"@type":"CROSSREF","@value":"10.3390/medicines7100064_references_DOI_SLo9GclPQq8i16Um290RuqAWCHm"}]}