{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360013170867699072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/jacamr/dlab092"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jacamr/article-pdf/3/3/dlab092/39351549/dlab092.pdf"}}],"dc:title":[{"@value":"Extended-spectrum <b>β</b>-lactamases: an update on their characteristics, epidemiology and detection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the early 1980s, they have spread worldwide and an are now endemic in Enterobacterales isolated from both hospital-associated and community-acquired infections. As a result, they are a global public health concern. In the past, TEM- and SHV-type ESBLs were the predominant families of ESBLs. Today CTX-M-type enzymes are the most commonly found ESBL type with the CTX-M-15 variant dominating worldwide, followed in prevalence by CTX-M-14, and CTX-M-27 is emerging in certain parts of the world. The genes encoding ESBLs are often found on plasmids and harboured within transposons or insertion sequences, which has enabled their spread. In addition, the population of ESBL-producing Escherichia coli is dominated globally by a highly virulent and successful clone belonging to ST131. Today, there are many diagnostic tools available to the clinical microbiology laboratory and include both phenotypic and genotypic tests to detect β-lactamases. Unfortunately, when ESBLs are not identified in a timely manner, appropriate antimicrobial therapy is frequently delayed, resulting in poor clinical outcomes. Several analyses of clinical trials have shown mixed results with regards to whether a carbapenem must be used to treat serious infections caused by ESBLs or whether some of the older β-lactam-β-lactamase combinations such as piperacillin/tazobactam are appropriate. Some of the newer combinations such as ceftazidime/avibactam have demonstrated efficacy in patients. ESBL-producing Gram-negative pathogens will continue to be major contributor to antimicrobial resistance worldwide. It is essential that we remain vigilant about identifying them both in patient isolates and through surveillance studies.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380013170867698944","@type":"Researcher","foaf:name":[{"@value":"Mariana Castanheira"}],"jpcoar:affiliationName":[{"@value":"JMI Laboratories, North Liberty, IA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170867699073","@type":"Researcher","foaf:name":[{"@value":"Patricia J Simner"}],"jpcoar:affiliationName":[{"@value":"School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170867699072","@type":"Researcher","foaf:name":[{"@value":"Patricia A Bradford"}],"jpcoar:affiliationName":[{"@value":"Antimicrobial Development Specialists LLC, Nyack, NY, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"26321823"}],"prism:publicationName":[{"@value":"JAC-Antimicrobial Resistance"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2021-07-12","prism:volume":"3","prism:number":"3","prism:startingPage":"dlab092"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"http://academic.oup.com/jacamr/article-pdf/3/3/dlab092/39351549/dlab092.pdf"}],"createdAt":"2021-06-08","modifiedAt":"2021-07-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168784625792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isolation of Human Lineage, Fluoroquinolone-Resistant and Extended-β-Lactamase-Producing Escherichia coli Isolates from Companion Animals in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757415734016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genetic relatedness of third-generation cephalosporin-resistant Escherichia coli among livestock, farmers, and patients in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301473542772608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetic–pharmacodynamic analysis of cefmetazole against extended-spectrum β-lactamase-producing Enterobacteriaceae in dogs using Monte Carlo Simulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360582947621281920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetic and Pharmacodynamic Analysis of the Oxacephem Antibiotic Flomoxef against Extended-Spectrum β-Lactamase-Producing Enterobacterales from Dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381053613056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a PCR-dipstick DNA chromatography-based tool for the detection of CTX-M- and TEM-producing Escherichia coli and Klebsiella pneumoniae isolated from patients in Kafue and Katete districts of Zambia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390010292591845504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"MOLECULAR CHARACTERIZATION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GENES OF ENTEROBACTERIACEAE ISOLATED FROM MUNCIPAL AND HOSPITAL WASTEWATERS"},{"@language":"ja","@value":"都市下水と病院排水中の腸内細菌科細菌が保有するESBL産生遺伝子の特徴"}]},{"@id":"https://cir.nii.ac.jp/crid/1390014945756855424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<i>In vitro</i> efficacy of cephamycins against multiple          extended-spectrum β-lactamase-producing <i>Klebsiella pneumoniae</i>,            <i>Proteus mirabilis</i>, and <i>Enterobacter cloacae</i> isolates          from dogs and cats"},{"@value":"In vitro efficacy of cephamycins against multiple extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae isolates from dogs and cats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576037460749312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Simple and Rapid Detection of ESBL <i>bla</i><sub>SHV</sub> gene from an Urban River in Tokyo by Loop-Mediated Isothermal Amplification"}]},{"@id":"https://cir.nii.ac.jp/crid/1390580947975123328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comprehensive Identification of Drug-Resistant Bacteria in the Environment Using a Highly Sensitive Fluorescence <i>In Situ</i> Hybridization Technique and a Fluorescent Activated Cell Sorting"},{"@language":"ja","@value":"高感度蛍光<i>in situ</i>ハイブリダイゼーション法と蛍光細胞分取装置を使用した培養非依存的な環境中の薬剤耐性菌の網羅的検出"}]},{"@id":"https://cir.nii.ac.jp/crid/1390582495936943488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Estimation of latamoxef (moxalactam) dosage regimens against β-lactamase–producing Enterobacterales in dogs: a pharmacokinetic and pharmacodynamic analysis using Monte Carlo simulation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/jacamr/dlab092"},{"@type":"CROSSREF","@value":"10.3390/antibiotics10121463_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.2208/jscejer.77.7_iii_199_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.1292/jvms.24-0197_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.4265/bio.27.209_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.1016/j.onehlt.2023.100524_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.3390/ijms25021105_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.1186/s12879-025-10628-9_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.1292/jvms.23-0052_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.2208/jscejj.23-25045_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"},{"@type":"CROSSREF","@value":"10.3389/fvets.2023.1270137_references_DOI_A7IYqV73LnV8pBgMCRDyPxfgRby"}]}