{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360013172087123712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/gerona/gly256"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/biomedgerontology/article-pdf/75/4/621/33451450/gly256.pdf"}}],"dc:title":[{"@value":"Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Sarcopenia is the aging-associated progressive loss of skeletal muscle; however, the pathogenic mechanism of sarcopenia is not clear. The orexigenic hormone ghrelin stimulates growth hormone secretion, increases food intake, and promotes adiposity. Here we showed that fasting-induced muscle loss was exacerbated in old ghrelin-null (Ghrl–/–) mice, exhibiting decreased expression of myogenic regulator MyoD and increased expression of protein degradation marker MuRF1, as well as altered mitochondrial function. Moreover, acylated ghrelin and unacylated ghrelin treatments significantly increased mitochondrial respiration capacity in muscle C2C12 cells. Consistently, acylated ghrelin and unacylated ghrelin treatments effectively increased myogenic genes and decreased degradation genes in the muscle in fasted old Ghrl–/– mice, possibly by stimulating insulin and adenosine monophosphate-activated protein kinase pathways. Furthermore, Ghrl–/– mice showed a profile of pro-inflammatory gut microbiota, exhibiting reduced butyrate-producing bacteria Roseburia and ClostridiumXIVb. Collectively, our results showed that ghrelin has a major role in the maintenance of aging muscle via both muscle-intrinsic and -extrinsic mechanisms. Acylated ghrelin and unacylated ghrelin enhanced muscle anabolism and exerted protective effects for muscle atrophy. Because unacylated ghrelin is devoid of the obesogenic side effect seen with acylated ghrelin, it represents an attractive therapeutic option for sarcopenia.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380013172087123584","@type":"Researcher","foaf:name":[{"@value":"Chia-Shan Wu"}],"jpcoar:affiliationName":[{"@value":"Department of Nutrition and Food Science, Texas A&M University, College Station"},{"@value":"USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123713","@type":"Researcher","foaf:name":[{"@value":"Qiong Wei"}],"jpcoar:affiliationName":[{"@value":"USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"},{"@value":"Division of Endocrinology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123722","@type":"Researcher","foaf:name":[{"@value":"Hongying Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Nutrition and Food Science, Texas A&M University, College Station"},{"@value":"Laboratory of Lipid and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123714","@type":"Researcher","foaf:name":[{"@value":"Da Mi Kim"}],"jpcoar:affiliationName":[{"@value":"Department of Nutrition and Food Science, Texas A&M University, College Station"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123585","@type":"Researcher","foaf:name":[{"@value":"Miriam Balderas"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123716","@type":"Researcher","foaf:name":[{"@value":"Guoyao Wu"}],"jpcoar:affiliationName":[{"@value":"Department of Animal Science, Texas A&M University, College Station"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123718","@type":"Researcher","foaf:name":[{"@value":"John Lawler"}],"jpcoar:affiliationName":[{"@value":"Department of Health and Kinesiology, Texas A&M University, College Station"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123720","@type":"Researcher","foaf:name":[{"@value":"Stephen Safe"}],"jpcoar:affiliationName":[{"@value":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123721","@type":"Researcher","foaf:name":[{"@value":"Shaodong Guo"}],"jpcoar:affiliationName":[{"@value":"Department of Nutrition and Food Science, Texas A&M University, College Station"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123715","@type":"Researcher","foaf:name":[{"@value":"Sridevi Devaraj"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123717","@type":"Researcher","foaf:name":[{"@value":"Zheng Chen"}],"jpcoar:affiliationName":[{"@value":"The University of Texas Health Science Center at Houston"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013172087123712","@type":"Researcher","foaf:name":[{"@value":"Yuxiang Sun"}],"jpcoar:affiliationName":[{"@value":"Department of Nutrition and Food Science, Texas A&M University, College Station"},{"@value":"USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380013172087123719","@type":"Researcher","foaf:name":[{"@value":"Rozalyn Anderson"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10795006"},{"@type":"EISSN","@value":"1758535X"}],"prism:publicationName":[{"@value":"The Journals of Gerontology: Series A"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2018-11-08","prism:volume":"75","prism:number":"4","prism:startingPage":"621","prism:endingPage":"630"},"reviewed":"false","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"http://academic.oup.com/biomedgerontology/article-pdf/75/4/621/33451450/gly256.pdf"}],"createdAt":"2018-11-08","modifiedAt":"2020-07-01","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360576118692656128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/gerona/gly256"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2021.12.044_references_DOI_EddA88KUfuqjziwAhljb45xOiNr"}]}