{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360016864415990144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1246/bcsj.20230131"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/bcsj/article-pdf/96/9/852/56150698/bcsj.20230131.pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Time-Resolved Diffusion Method to Detect and Reveal Protein Reactions Leading to Their Functions"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Proteins are unique natural macromolecules with high selectivity and efficiency for their functions. Understanding the chemical reaction mechanisms of proteins has long been an important and attractive research subject. To study the reactions, various experimental techniques have been developed. However, the time-resolved detection of conformational changes and intermolecular interactions remains a difficult problem, although dynamics are crucial for elucidating the reaction mechanism at the molecular level. Here, time-resolved diffusion (TRD) methods developed to monitor hidden dynamics are introduced. After describing the principle, this review mainly focuses on some applications demonstrating the importance of the time-resolved detection of diffusion-sensitive conformational change (DSCC), which can reveal spectrally silent reaction processes. Correlation between DSCC and enzymatic function showed that conformation changes detected by DSCC are closely related to biological functions such as enzymatic reactions and DNA recognition. Furthermore, the TRD method can detect signal transduction processes of photosensor proteins. Hence, the time-resolved detection of DSCC is appropriate to study mechanisms of protein functions. Since this method can detect intermolecular interactions between enzymes and substrates in time-domain, one of interesting applications is a time-resolved biosensor for transient species. Advantages of the method and future perspective are discussed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016864415990272","@type":"Researcher","foaf:name":[{"@value":"Masahide Terazima"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502 , Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092673"},{"@type":"EISSN","@value":"13480634"}],"prism:publicationName":[{"@value":"Bulletin of the Chemical Society of Japan"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2023-07-25","prism:volume":"96","prism:number":"9","prism:startingPage":"852","prism:endingPage":"871"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/bcsj/article-pdf/96/9/852/56150698/bcsj.20230131.pdf"}],"createdAt":"2023-07-24","modifiedAt":"2024-01-16","project":[{"@id":"https://cir.nii.ac.jp/crid/1040862776831371520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K21099"},{"@type":"JGN","@value":"JP23K21099"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21099/"}],"notation":[{"@language":"ja","@value":"空間制限液滴内でのタンパク質構造変化・反応の時間分解検出と液滴の特性解明"},{"@language":"en","@value":"Time-resolved detection of protein conformation changes and reactions in space limited liquid droplets"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335723494400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Light-Induced Conformational Changes in Full-Length Arabidopsis thaliana Cryptochrome."}]},{"@id":"https://cir.nii.ac.jp/crid/1050001335841060096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pressure-sensitive reaction yield of the TePixD blue-light sensor protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282676671655552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Kinetics of conformational changes of the FKF1-LOV domain upon photoexcitation."},{"@value":"Kinetics of conformational changes of the FKF1-LOV domain upon photoexcitaion"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810694946432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Light-Induced Conformational Change and Transient Dissociation Reaction of the BLUF Photoreceptor Synechocystis PixD (Slr1694)."}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285764199552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Macromolecular crowding effects on reactions of TePixD (Tll0078)."},{"@value":"Macromolecular Crowding Effects on Reactions of TePixD (Tll0078)<sup>†</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564288341505024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dynamics of Conformational Changes in Full-Length Phytochrome from Cyanobacterium Synechocystis sp. PCC6803 (Cph1) Monitored by Time-Resolved Translational Diffusion Detection"},{"@value":"Dynamics of Conformational Changes in Full-Length Phytochrome from Cyanobacterium <i>Synechocystis</i> sp. PCC6803 (Cph1) Monitored by Time-Resolved Translational Diffusion Detection"},{"@value":"Dynamics of conformation changes in full-length Phytochrome from cyanobacterium Synechocystis sp. PCC6803 (Cph1) monitored by time-resolved translational diffusion detection"}]},{"@id":"https://cir.nii.ac.jp/crid/1050578141068519168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Time-resolved detection of light-induced conformational changes of heliorhodopsin"}]},{"@id":"https://cir.nii.ac.jp/crid/1050582154146348672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Layer-by-layer designer nanoarchitectonics for physical and chemical communications in functional materials"}]},{"@id":"https://cir.nii.ac.jp/crid/1050583314577981696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interface‐Interactive Nanoarchitectonics: Solid and/or Liquid"},{"@value":"Interface-interactive nanoarchitectonics: solid 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