Synaptic pruning through glial synapse engulfment upon motor learning
書誌事項
- 公開日
- 2022-11
- 資源種別
- journal article
- 権利情報
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- https://www.springer.com/tdm
- https://www.springer.com/tdm
- DOI
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- 10.1038/s41593-022-01184-5
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement in synaptic pruning has a role in memory formation remains elusive. Using newly developed phagocytosis reporter mice and three-dimensional ultrastructural characterization, we found that synaptic engulfment by cerebellar Bergmann glia (BG) frequently occurred upon cerebellum-dependent motor learning in mice. We observed increases in pre- and postsynaptic nibbling by BG along with a reduction in spine volume after learning. Pharmacological blockade of engulfment with Annexin V inhibited both the spine volume reduction and overnight improvement of motor adaptation. These results indicate that BG contribute to the refinement of the mature cerebellar cortical circuit through synaptic engulfment during motor learning.
収録刊行物
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- Nature Neuroscience
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Nature Neuroscience 25 (11), 1458-1469, 2022-11
Springer Science and Business Media LLC
