{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360016869770227072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adfm.202104026"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202104026"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adfm.202104026"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202104026"}}],"dc:title":[{"@value":"Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Aggregation‐caused fluorescence quenching with insufficient production of reactive oxygen species (ROS) has limited the application of photosensitizers (PSs) in fluorescence‐imaging‐guided photodynamic therapy (PDT). Aggregation‐induced emission PSs (AIE‐PSs) exhibit enhanced fluorescence intensity and a high efficiency of ROS generation in the aggregation state, which provides an opportunity to solve the above problems. Herein, a series of AIE‐PSs are successfully designed and synthesized by adjusting the D–A intensity through molecular engineering. The photophysical properties and theoretical calculations prove that the synergistic effect of 3,4‐ethylenedioxythiophene and quinolinium increases the intramolecular charge transfer effect (ICT) of the whole molecule and promotes the intersystem crossing (ISC) from the lowest excited singlet state (S<jats:sub>1</jats:sub>) to the lowest triplet state (T<jats:sub>1</jats:sub>). Among these AIE‐PSs, the optimal AIE‐PS (TPA‐DT‐Qy) exhibits the highest generation yield of <jats:sup>1</jats:sup>O<jats:sub>2</jats:sub> (5.3‐fold of Rose Bengal). Further PDT experiments show that the TPA‐DT‐Qy has a highly efficient photodynamic ablation of breast cancer cells (MCF‐7 and MDA‐MB‐231) under white light irradiation. Moreover, the photodynamic antibacterial study indicates that TPA‐DT‐Qy has the discrimination and excellent photodynamic inactivation of <jats:italic>S. aureus</jats:italic>. This work provides a feasible strategy for the molecular engineering of novel AIE‐PSs to improve the development of fluorescence‐imaging‐guided PDT.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016869770227078","@type":"Researcher","foaf:name":[{"@value":"Gang Yuan"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227080","@type":"Researcher","foaf:name":[{"@value":"Cheng Lv"}],"jpcoar:affiliationName":[{"@value":"Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine Shanghai East Hospital Tongji University School of Medicine  1800 Yuntai Road Shanghai 200123 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227076","@type":"Researcher","foaf:name":[{"@value":"Jichao Liang"}],"jpcoar:affiliationName":[{"@value":"College of Life Science Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227079","@type":"Researcher","foaf:name":[{"@value":"Xinxin Zhong"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227082","@type":"Researcher","foaf:name":[{"@value":"Yuan Li"}],"jpcoar:affiliationName":[{"@value":"Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine Shanghai East Hospital Tongji University School of Medicine  1800 Yuntai Road Shanghai 200123 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227081","@type":"Researcher","foaf:name":[{"@value":"Jiacun He"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227075","@type":"Researcher","foaf:name":[{"@value":"Anjing Zhao"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227072","@type":"Researcher","foaf:name":[{"@value":"Li Li"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227074","@type":"Researcher","foaf:name":[{"@value":"Yuanhe Shao"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227077","@type":"Researcher","foaf:name":[{"@value":"Xiuhua Zhang"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227073","@type":"Researcher","foaf:name":[{"@value":"Shengfu Wang"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227083","@type":"Researcher","foaf:name":[{"@value":"Yu Cheng"}],"jpcoar:affiliationName":[{"@value":"Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine Shanghai East Hospital Tongji University School of Medicine  1800 Yuntai Road Shanghai 200123 China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869770227084","@type":"Researcher","foaf:name":[{"@value":"Hanping He"}],"jpcoar:affiliationName":[{"@value":"Collaborative Innovation Center for Advanced Organic Chemical Materials Coconstructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hubei University  Youyi Road 368, Wuchang Wuhan Hubei 430062 China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1616301X"},{"@type":"EISSN","@value":"16163028"}],"prism:publicationName":[{"@value":"Advanced Functional Materials"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2021-06-25","prism:volume":"31","prism:number":"36"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202104026"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adfm.202104026"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202104026"}],"createdAt":"2021-06-26","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360016863185938432","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Indole Aggregation-induced Emission Molecule Based Nanoparticles for Ablation of Mouse Cancer Cells in Vitro"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/adfm.202104026"},{"@type":"CROSSREF","@value":"10.1246/cl.230115_references_DOI_KlA4ePpK3RLFkUivK0B42JyPaD8"}]}