{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360016869791716992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00204-020-02936-7"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s00204-020-02936-7.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s00204-020-02936-7/fulltext.html"}}],"dc:title":[{"@value":"Inhibition and induction of CYP enzymes in humans: an update"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies and toxic compounds in the environment. The inhibition and induction of CYPs are major mechanisms causing pharmacokinetic drug–drug interactions. This review presents a comprehensive update on the inhibitors and inducers of the specific CYP enzymes in humans. The focus is on the more recent human in vitro and in vivo findings since the publication of our previous review on this topic in 2008. In addition to the general presentation of inhibitory drugs and inducers of human CYP enzymes by drugs, herbal remedies, and toxic compounds, an in-depth view on tyrosine-kinase inhibitors and antiretroviral HIV medications as victims and perpetrators of drug–drug interactions is provided as examples of the current trends in the field. Also, a concise overview of the mechanisms of CYP induction is presented to aid the understanding of the induction phenomena.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016869791716992","@type":"Researcher","foaf:name":[{"@value":"Jukka Hakkola"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869791716994","@type":"Researcher","foaf:name":[{"@value":"Janne Hukkanen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869791716995","@type":"Researcher","foaf:name":[{"@value":"Miia Turpeinen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016869791716993","@type":"Researcher","foaf:name":[{"@value":"Olavi Pelkonen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03405761"},{"@type":"EISSN","@value":"14320738"}],"prism:publicationName":[{"@value":"Archives of Toxicology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-10-27","prism:volume":"94","prism:number":"11","prism:startingPage":"3671","prism:endingPage":"3722"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/s00204-020-02936-7.pdf"},{"@id":"https://link.springer.com/article/10.1007/s00204-020-02936-7/fulltext.html"}],"createdAt":"2020-10-27","modifiedAt":"2024-08-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282240371072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391872014976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of P-Glycoprotein-Mediated Drug-Endogenous Substrate Interactions on Androgen and Blood-Brain Barrier Permeability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360026337944216704","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Advances in In silico Predictive Models for DDI Prediction: Implications and Practical Applications in Drug Discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298338419810304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360299767181777024","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Quantitative prediction of CYP3A induction-mediated drug-drug interactions in clinical practice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380584550016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861288769759616","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"WITHDRAWN: Drugs that induce and inhibit cytochrome P450. 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