{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360017279876527872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s42255-023-00742-w"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s42255-023-00742-w.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s42255-023-00742-w"}},{"identifier":{"@type":"DOI","@value":"10.1101/2022.06.06.22275997"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/2022.06.06.22275997"}},{"identifier":{"@type":"PMID","@value":"36805565"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Obesity is a major risk factor for COVID-19 severity; however, the mechanisms underlying this relationship are not fully understood. Since obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index (BMI) using Mendelian randomization (MR). This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using MR. We found that a standard deviation increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71,\n                  <jats:italic>P</jats:italic>\n                  = 1.63 × 10\n                  <jats:sup>−10</jats:sup>\n                  ). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing,\n                  <jats:italic>NPNT</jats:italic>\n                  was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity.\n                </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380017279876527760","@type":"Researcher","foaf:name":[{"@value":"Satoshi Yoshiji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527640","@type":"Researcher","foaf:name":[{"@value":"Guillaume Butler-Laporte"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527893","@type":"Researcher","foaf:name":[{"@value":"Tianyuan Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527624","@type":"Researcher","foaf:name":[{"@value":"Julian Daniel Sunday Willett"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527642","@type":"Researcher","foaf:name":[{"@value":"Chen-Yang Su"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527501","@type":"Researcher","foaf:name":[{"@value":"Tomoko Nakanishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527623","@type":"Researcher","foaf:name":[{"@value":"David R. Morrison"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527621","@type":"Researcher","foaf:name":[{"@value":"Yiheng Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527499","@type":"Researcher","foaf:name":[{"@value":"Kevin Liang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527494","@type":"Researcher","foaf:name":[{"@value":"Michael Hultström"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527766","@type":"Researcher","foaf:name":[{"@value":"Yann Ilboudo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527761","@type":"Researcher","foaf:name":[{"@value":"Zaman Afrasiabi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527763","@type":"Researcher","foaf:name":[{"@value":"Shanshan Lan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876528001","@type":"Researcher","foaf:name":[{"@value":"Naomi Duggan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527630","@type":"Researcher","foaf:name":[{"@value":"Chantal DeLuca"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527745","@type":"Researcher","foaf:name":[{"@value":"Mitra Vaezi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527754","@type":"Researcher","foaf:name":[{"@value":"Chris Tselios"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527502","@type":"Researcher","foaf:name":[{"@value":"Xiaoqing Xue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527876","@type":"Researcher","foaf:name":[{"@value":"Meriem Bouab"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527627","@type":"Researcher","foaf:name":[{"@value":"Fangyi Shi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527771","@type":"Researcher","foaf:name":[{"@value":"Laetitia Laurent"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527775","@type":"Researcher","foaf:name":[{"@value":"Hans Markus Münter"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527878","@type":"Researcher","foaf:name":[{"@value":"Marc Afilalo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527753","@type":"Researcher","foaf:name":[{"@value":"Jonathan Afilalo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527744","@type":"Researcher","foaf:name":[{"@value":"Vincent Mooser"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527755","@type":"Researcher","foaf:name":[{"@value":"Nicholas J. Timpson"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527622","@type":"Researcher","foaf:name":[{"@value":"Hugo Zeberg"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527757","@type":"Researcher","foaf:name":[{"@value":"Sirui Zhou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527773","@type":"Researcher","foaf:name":[{"@value":"Vincenzo Forgetta"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527888","@type":"Researcher","foaf:name":[{"@value":"Yossi Farjoun"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017279876527751","@type":"Researcher","foaf:name":[{"@value":"J. Brent Richards"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"25225812"}],"prism:publicationName":[{"@value":"Nature Metabolism"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2023-02-20","prism:volume":"5","prism:number":"2","prism:startingPage":"248","prism:endingPage":"264"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://www.nature.com/articles/s42255-023-00742-w.pdf"},{"@id":"https://www.nature.com/articles/s42255-023-00742-w"},{"@id":"https://syndication.highwire.org/content/doi/10.1101/2022.06.06.22275997"}],"createdAt":"2023-02-20","modifiedAt":"2024-12-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Proteome","dc:title":"Proteome"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=COVID-19","dc:title":"COVID-19"},{"@id":"https://cir.nii.ac.jp/all?q=Obesity","dc:title":"Obesity"},{"@id":"https://cir.nii.ac.jp/all?q=Mendelian%20Randomization%20Analysis","dc:title":"Mendelian Randomization Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040295879331722496","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22KJ1190"},{"@type":"JGN","@value":"JP22KJ1190"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ1190/"}],"notation":[{"@language":"ja","@value":"包括的マルチオミクス解析による呼吸器難治性疾患の時空間的病態解明と創薬への応用"},{"@language":"en","@value":"Comprehensive multiomics analysis to elucidate temporal and spatial pathophysiology of respiratory diseases for their application to drug discovery."}]},{"@id":"https://cir.nii.ac.jp/crid/1040295879332002560","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22KJ1696"},{"@type":"JGN","@value":"JP22KJ1696"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ1696/"}],"notation":[{"@language":"ja","@value":"非侵襲的膵β細胞イメージング法による糖尿病の病態解明およびその応用"},{"@language":"en","@value":"Non-invasive beta-cell imaging for understanding the etiology of diabetes"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145753051008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013171336711040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172597422720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integrated analysis of multimodal single-cell data"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013173206892544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Co-regulatory networks of human serum proteins link genetics to disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870036798464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870448261632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017285976378240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tirzepatide Once Weekly for the Treatment of Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017285981165440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017286652511360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017286653494016","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017286653558400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of smoking, lung function and COPD in COVID‐19 risk: a two‐step Mendelian randomization study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017287225198848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discriminative Accuracy of FEV<sub>1</sub>:FVC Thresholds for COPD-Related Hospitalization and Mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017287246717568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017287832814464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mendelian Randomization Studies Do Not Support a Role for Vitamin D in Coronary Artery Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389823367680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Circulating proteins to predict COVID-19 severity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292274168272640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A general framework for estimating the relative pathogenicity of human genetic variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617917029376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A global reference for human genetic variation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619297448576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluating the potential role of pleiotropy in Mendelian randomization studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619539235456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643771156608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646776906624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanisms underlying variations in lung function: a systems genetics analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757190199168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Causal associations between body fat accumulation and COVID-19 severity: A Mendelian randomization study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298760876969856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298760958511744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synergistic insights into human health from aptamer- and antibody-based proteomic profiling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298761828478208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TwoStepCisMR: A Novel Method and R Package for Attenuating Bias in cis-Mendelian Randomization Analyses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298761955989888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The human genetic epidemiology of COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298761975887360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762023859072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762037879936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762045420800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathways to Severe COVID‐19 for People with Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298765149766272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiometabolic Traits, Sepsis, and Severe COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181954077056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093614625024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selecting instruments for Mendelian randomization in the wake of genome-wide association studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095125587456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mendelian randomization in cardiometabolic disease: challenges in evaluating causality"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096072168704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576120027031424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576121997425280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235941693824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236933092736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extracellular matrix remodeling facilitates obesity-associated cancer progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236936916352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Large-scale integration of the plasma proteome with genetics and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236947659520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236997067904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236997567104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236997591552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580238112771200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580238112966144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239496136960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Liraglutide Does Not Adversely Impact Fat‐Free Mass Loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239498171136","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of a COPD-Associated\n                  <i>NPNT</i>\n                  Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239498578560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567862254464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567863986816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The <tt>sva</tt> package for removing batch effects and other unwanted variation in high-throughput experiments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291585919360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861710837756800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861710910136192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe 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