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CEP19–RABL2–IFT-B axis controls BBSome-mediated ciliary GPCR export
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- Yohei Katoh
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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- Kazuhisa Nakayama
- Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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- Gregory Pazour
- editor
Bibliographic Information
- Published
- 2022-11-01
- Resource Type
- journal article
- DOI
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- 10.1091/mbc.e22-05-0161
- Publisher
- American Society for Cell Biology (ASCB)
Search this article
Description
<jats:p>The IFT25-IFT27 dimer constitutes the interface between the IFT-B complex and BBSome. We show that IFT25-IFT27 and RABL2-GTP bind mutually exclusive to the IFT74-IFT81 dimer in the IFT-B complex. RABL2-GTP suppresses BBSome-mediated ciliary GPCR export. However, its CEP19-dependent entry into cilia is dispensable for the GPCR export suppression.</jats:p>
Journal
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- Molecular Biology of the Cell
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Molecular Biology of the Cell 33 (13), ar126-, 2022-11-01
American Society for Cell Biology (ASCB)
