<scp>AeiA</scp> is a novel autophagy‐related protein that promotes peroxisome degradation by pexophagy in <i>Aspergillus oryzae</i>
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- Joichiro Nishio
- Department of Biotechnology College of Life Sciences, Ritsumeikan University Kusatsu Japan
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- Yoshiaki Takahashi
- Department of Biotechnology College of Life Sciences, Ritsumeikan University Kusatsu Japan
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- Masahiro Kasahara
- Department of Biotechnology College of Life Sciences, Ritsumeikan University Kusatsu Japan
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- Yoichi Takeda
- Department of Biotechnology College of Life Sciences, Ritsumeikan University Kusatsu Japan
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- Takashi Kikuma
- Department of Biotechnology College of Life Sciences, Ritsumeikan University Kusatsu Japan
書誌事項
- 公開日
- 2023-02-02
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/1873-3468.14589
- 公開者
- Wiley
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説明
<jats:p>Autophagy is classified into nonselective and selective autophagy, depending on the specificity of substrate degradation. In the filamentous fungus <jats:italic>Aspergillus oryzae</jats:italic>, selective autophagy, which includes pexophagy and mitophagy, has been observed. However, the molecular mechanism underlying selective autophagy in filamentous fungi remains unclear. Here, we identified a novel protein that interacts with the autophagy‐related protein Atg8 in <jats:italic>A. oryzae</jats:italic>, named AoAtg8‐interacting protein A (AeiA). AeiA was localized to AoAtg8‐positive autophagic membrane structures and peroxisomes. Moreover, peroxisomal trafficking into the vacuole was reduced in AeiA disruptants. Taken together, AeiA is a novel selective autophagy‐related protein that contributes to pexophagy in <jats:italic>A. oryzae</jats:italic>.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 597 (5), 608-617, 2023-02-02
Wiley
