{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360017285983173632.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.2105253118"}},{"identifier":{"@type":"URI","@value":"http://www.pnas.org/syndication/doi/10.1073/pnas.2105253118"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.2105253118"}}],"dc:title":[{"@value":"SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Significance</jats:title>\n                  <jats:p>SARS-CoV-2 emerged because of viral spillover from animals to humans, and spillback to other animal species has been observed with accelerating frequency. Cross-species transmission generally results in the rapid adaptation of the virus to the new host, and repeated transmissions may hasten viral evolution and novel strain emergence. We report the surprisingly rapid selection of numerous SARS-CoV-2 variants in cell culture and following infection of nonhuman mammalian hosts, including dogs and cats. These molecular changes in SARS-CoV-2 provide insight into mechanisms of viral host adaptation, lay the groundwork for additional studies assessing dominant variant fitness and phenotype, and highlight the potential for human reinfection with new viral variants arising in species in close and frequent contact with humans.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380017285983173636","@type":"Researcher","foaf:name":[{"@value":"Laura Bashor"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017285983173634","@type":"Researcher","foaf:name":[{"@value":"Roderick B. Gagne"}],"jpcoar:affiliationName":[{"@value":"Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017285983173632","@type":"Researcher","foaf:name":[{"@value":"Angela M. Bosco-Lauth"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017285983173637","@type":"Researcher","foaf:name":[{"@value":"Richard A. Bowen"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017285983173633","@type":"Researcher","foaf:name":[{"@value":"Mark Stenglein"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017285983173635","@type":"Researcher","foaf:name":[{"@value":"Sue VandeWoude"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2021-10-29","prism:volume":"118","prism:number":"44","prism:startingPage":"e2105253118"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://www.pnas.org/syndication/doi/10.1073/pnas.2105253118"},{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.2105253118"}],"createdAt":"2021-10-29","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360298757430046848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230617061120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A simulation of geographic distribution for the emergence of consequential SARS-CoV-2 variant lineages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705556732416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Insertion and deletion mutations preserved in SARS-CoV-2 variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707395091584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronaviruses"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.2105253118"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2022.105742_references_DOI_PlbqDHE8KlqwvPOs4qnNGBMKwu4"},{"@type":"CROSSREF","@value":"10.1038/s41598-022-14308-5_references_DOI_PlbqDHE8KlqwvPOs4qnNGBMKwu4"},{"@type":"CROSSREF","@value":"10.1007/s00203-023-03493-0_references_DOI_PlbqDHE8KlqwvPOs4qnNGBMKwu4"},{"@type":"CROSSREF","@value":"10.1186/s12862-022-02078-7_references_DOI_PlbqDHE8KlqwvPOs4qnNGBMKwu4"}]}