{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360017286989615488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/smll.202100479"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202100479"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.202100479"}}],"dc:title":[{"@value":"Peritumoral Microgel Reservoir for Long‐Term Light‐Controlled Triple‐Synergistic Treatment of Osteosarcoma with Single Ultra‐Low Dose"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Local minimally invasive injection of anticancer therapies is a compelling approach to maximize the utilization of drugs and reduce the systemic adverse drug effects. However, the clinical translation is still hampered by many challenges such as short residence time of therapeutic agents and the difficulty in achieving multi‐modulation combination therapy. Herein, mesoporous silica‐coated gold nanorods (AuNR@SiO<jats:sub>2</jats:sub>) core‐shell nanoparticles are fabricated to facilitate drug loading while rendering them photothermally responsive. Subsequently, AuNR@SiO<jats:sub>2</jats:sub> is anchored into a monodisperse photocrosslinkable gelatin (GelMA) microgel through one‐step microfluidic technology. Chemotherapeutic drug doxorubicin (DOX) is loaded into AuNR@SiO<jats:sub>2</jats:sub> and 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA) is loaded in the microgel layer. The osteosarcoma targeting ligand alendronate is conjugated to AuNR@SiO<jats:sub>2</jats:sub> to improve the tumor targeting. The microgel greatly improves the injectability since they can be dispersed in buffer and the injectability and degradability are adjustable by microfluidics during the fabrication. The drug release can, in turn, be modulated by multi‐round light‐trigger. Importantly, a single super low drug dose (1 mg kg<jats:sup>−1</jats:sup> DOX with 5 mg kg<jats:sup>−1</jats:sup> DMXAA) with peritumoral injection generates long‐term therapeutic effect and significantly inhibited tumor growth in osteosarcoma bearing mice. Therefore, this nanocomposite@microgel system can act as a peritumoral reservoir for long‐term effective osteosarcoma treatment.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380017286989615494","@type":"Researcher","foaf:name":[{"@value":"Jiaqi Yan"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Shanghai Institute of Traumatology and Orthopaedics RuiJin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  149 ChongqingNan Road Shanghai 200020 P. R. China"},{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"},{"@value":"Turku Bioscience Centre University of Turku and Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615492","@type":"Researcher","foaf:name":[{"@value":"Yichuan Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopedics Peking University Shougang Hospital  No.9 Jinyuanzhuang Rd, Shijingshan District Beijing 100144 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615491","@type":"Researcher","foaf:name":[{"@value":"Meixin Ran"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Shanghai Institute of Traumatology and Orthopaedics RuiJin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  149 ChongqingNan Road Shanghai 200020 P. R. China"},{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"},{"@value":"Turku Bioscience Centre University of Turku and Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615498","@type":"Researcher","foaf:name":[{"@value":"Rawand A. Mustafa"}],"jpcoar:affiliationName":[{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615495","@type":"Researcher","foaf:name":[{"@value":"Huanhuan Luo"}],"jpcoar:affiliationName":[{"@value":"Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials Department of Orthopaedics The Second Affiliated Hospital of Jiaxing University  Jiaxing 314000 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615499","@type":"Researcher","foaf:name":[{"@value":"Jixiang Wang"}],"jpcoar:affiliationName":[{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"},{"@value":"Turku Bioscience Centre University of Turku and Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615488","@type":"Researcher","foaf:name":[{"@value":"Jan‐Henrik Smått"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Science and Engineering Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615496","@type":"Researcher","foaf:name":[{"@value":"Jessica M. Rosenholm"}],"jpcoar:affiliationName":[{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615497","@type":"Researcher","foaf:name":[{"@value":"Wenguo Cui"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Shanghai Institute of Traumatology and Orthopaedics RuiJin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  149 ChongqingNan Road Shanghai 200020 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615490","@type":"Researcher","foaf:name":[{"@value":"Yong Lu"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Shanghai Institute of Traumatology and Orthopaedics RuiJin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  149 ChongqingNan Road Shanghai 200020 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615493","@type":"Researcher","foaf:name":[{"@value":"Zhenpeng Guan"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopedics Peking University Shougang Hospital  No.9 Jinyuanzhuang Rd, Shijingshan District Beijing 100144 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017286989615489","@type":"Researcher","foaf:name":[{"@value":"Hongbo Zhang"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Shanghai Institute of Traumatology and Orthopaedics RuiJin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  149 ChongqingNan Road Shanghai 200020 P. R. China"},{"@value":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University  Turku 20520 Finland"},{"@value":"Turku Bioscience Centre University of Turku and Åbo Akademi University  Turku 20520 Finland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16136810"},{"@type":"EISSN","@value":"16136829"}],"prism:publicationName":[{"@value":"Small"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2021-06-25","prism:volume":"17","prism:number":"31"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202100479"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/smll.202100479"}],"createdAt":"2021-06-26","modifiedAt":"2023-08-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282436641664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combination therapy with bevacizumab and a <scp>CCR2</scp> inhibitor for human ovarian cancer: An in vivo validation study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/smll.202100479"},{"@type":"CROSSREF","@value":"10.1002/cam4.5674_references_DOI_GdSTuYkE7cCuWRQr8Ux6kZuQO1y"}]}