{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360017288288694912.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/jce.13899"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjce.13899"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.13899"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jce.13899"}}],"dc:title":[{"@value":"P‐wave morphology and multipolar intracardiac atrial activation to facilitate nonpulmonary vein trigger localization"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Nonpulmonary vein (non‐PV) triggers of atrial fibrillation (AF) are targets for ablation but their localization remains challenging. The aim of this study was to describe P‐wave (PW) morphologic characteristics and intra‐atrial activation patterns and timing from multipolar coronary sinus (CS) and crista terminalis (CT) catheters that localize non‐PV triggers.</jats:p></jats:sec><jats:sec><jats:title>Methods and Results</jats:title><jats:p>Selective pacing from six right and nine left atrial common non‐PV trigger sites was performed in 30 consecutive patients. We analyzed 12 lead ECG features based on PW duration, amplitude and morphology, and patterns and timing of multipolar activation for all 15 sites. Regionalization and then precise localization required criteria present in at least 70% of assessments at each pacing site. The algorithm was then prospectively evaluated by four blinded observers in a validation cohort of 18 consecutive patients undergoing the same pacing protocol and 60 consecutive patients who underwent successful non‐PV trigger ablation.</jats:p><jats:p>The algorithm for site regionalization included 1) negative PW in V1, ≥30 µV change in PW amplitude across the leads V1‐V3, and PW duration ≤100 milliseconds in lead 2 and 2) unique intra‐atrial activation patterns and timing noted in the multipolar catheters. Specific ECG and intra‐atrial activation timing characteristics included in the algorithm allowed for more precise site localization after regionalization. In the prospective evaluation, the algorithm identified the site of origin for 72% of paced and 70% of spontaneous non‐PV trigger sites.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>An algorithm based on PW morphology and intra‐atrial multipolar activation pattern and timing can help identify non‐PV trigger sites of origin.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380017288288695042","@type":"Researcher","foaf:name":[{"@value":"Maciej Kubala"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694916","@type":"Researcher","foaf:name":[{"@value":"Irene Lucena‐Padros"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694923","@type":"Researcher","foaf:name":[{"@value":"Shuanglun Xie"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694917","@type":"Researcher","foaf:name":[{"@value":"Ruben Casado‐Arroyo"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"@value":"Department of Cardiology Erasme University Hospital, Université Libre de Bruxelles Brussels Belgium"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288695040","@type":"Researcher","foaf:name":[{"@value":"David S. Frankel"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288695041","@type":"Researcher","foaf:name":[{"@value":"David Lin"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694913","@type":"Researcher","foaf:name":[{"@value":"Pasquale Santangeli"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694919","@type":"Researcher","foaf:name":[{"@value":"Gregory E. Supple"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694914","@type":"Researcher","foaf:name":[{"@value":"Sanjay Dixit"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694922","@type":"Researcher","foaf:name":[{"@value":"Cory M. Tschabrunn"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694921","@type":"Researcher","foaf:name":[{"@value":"Jackson J. Liang"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694915","@type":"Researcher","foaf:name":[{"@value":"Jiandu Yang"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694920","@type":"Researcher","foaf:name":[{"@value":"Matthew C. Hyman"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694912","@type":"Researcher","foaf:name":[{"@value":"Erica S. Zado"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1380017288288694918","@type":"Researcher","foaf:name":[{"@value":"Francis E. Marchlinski"}],"jpcoar:affiliationName":[{"@value":"Cardiac Electrophysiology Program, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10453873"},{"@type":"EISSN","@value":"15408167"}],"prism:publicationName":[{"@value":"Journal of Cardiovascular Electrophysiology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-03-12","prism:volume":"30","prism:number":"6","prism:startingPage":"865","prism:endingPage":"876"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjce.13899"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jce.13899"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jce.13899"}],"createdAt":"2019-03-05","modifiedAt":"2023-09-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360580230591620352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intra-atrial activation pattern is useful to localize the areas of non-pulmonary vein triggers of atrial fibrillation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/jce.13899"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0264894_references_DOI_6N0ygObFmAhQz6tBXpzZcPk2D4C"}]}