{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360019688983864448.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fimmu.2021.689019"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.689019/full"}}],"dc:title":[{"@value":"The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Recurrent pregnancy loss (RPL) is a common fertility problem that affects 1%-2% of couples all over the world. Despite exciting discoveries regarding the important roles of the decidual natural killer cell (dNK) and regulatory T cell in pregnancy, the immune heterogeneity in patients with unexplained recurrent pregnancy loss (URPL) remains elusive. Here, we profiled the transcriptomes of 13,953 CD45<jats:sup>+</jats:sup> cells from three normal and three URPL deciduas. Based on our data, the cellular composition revealed three major populations of immune cells including dNK cell, T cell, and macrophage, and four minor populations including monocytes, dendritic cell (DC), mast cell, and B cell. Especially, we identified a subpopulation of CSF1+ CD59+ KIRs-expressing dNK cells in normal deciduas, while the proportion of this subpopulation was decreased in URPL deciduas. We also identified a small subpopulation of activated dDCs that were accumulated mainly in URPL deciduas. Furthermore, our data revealed that in decidua at early pregnancy, CD8<jats:sup>+</jats:sup> T cells exhibited cytotoxic properties. The decidual macrophages expressed high levels of both M1 and M2 feature genes, which made them unique to the conventional M1/M2 classification. Our single-cell data revealed the immune heterogeneity in decidua and the potentially pathogenic immune variations in URPL.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380019688983864459","@type":"Researcher","foaf:name":[{"@value":"Chaoxia Cao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864463","@type":"Researcher","foaf:name":[{"@value":"Shuangli Lv"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864456","@type":"Researcher","foaf:name":[{"@value":"Zhihong Wei"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864455","@type":"Researcher","foaf:name":[{"@value":"Xinglin Hu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864452","@type":"Researcher","foaf:name":[{"@value":"Zijing Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864453","@type":"Researcher","foaf:name":[{"@value":"Liping Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864460","@type":"Researcher","foaf:name":[{"@value":"Jiao Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864454","@type":"Researcher","foaf:name":[{"@value":"Xiaohua Zhou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864450","@type":"Researcher","foaf:name":[{"@value":"Changchun Zeng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864449","@type":"Researcher","foaf:name":[{"@value":"Danna Su"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864461","@type":"Researcher","foaf:name":[{"@value":"Huiyun Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864458","@type":"Researcher","foaf:name":[{"@value":"Xuefeng Deng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864457","@type":"Researcher","foaf:name":[{"@value":"Ying Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864448","@type":"Researcher","foaf:name":[{"@value":"Zuhui Pu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864465","@type":"Researcher","foaf:name":[{"@value":"Ruiying Diao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864464","@type":"Researcher","foaf:name":[{"@value":"Liying Zhou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864466","@type":"Researcher","foaf:name":[{"@value":"Jiying Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864451","@type":"Researcher","foaf:name":[{"@value":"Pengfei Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380019688983864462","@type":"Researcher","foaf:name":[{"@value":"Lisha Mou"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16643224"}],"prism:publicationName":[{"@value":"Frontiers in Immunology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2021-06-07","prism:volume":"12","prism:startingPage":"689019"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.689019/full"}],"createdAt":"2021-06-07","modifiedAt":"2021-06-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302865551152896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Successful Pregnancy and Delivery at Term Following Intravenous Immunoglobulin Therapy with Heparin for Unexplained Recurrent Pregnancy Loss Suspected of Immunological Abnormalities: A Case Report and Brief Literature Review"}]},{"@id":"https://cir.nii.ac.jp/crid/1390863661276666496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Associations of Nutrients and Dietary Preferences with Recurrent Pregnancy Loss and Infertility"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3389/fimmu.2021.689019"},{"@type":"CROSSREF","@value":"10.3390/jcm12041250_references_DOI_aT31xEQShVtdSliNbr1lPxfZCyW"},{"@type":"CROSSREF","@value":"10.1272/jnms.jnms.2024_91-313_references_DOI_aT31xEQShVtdSliNbr1lPxfZCyW"}]}