{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021389815656704.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/jcpe.13908"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcpe.13908"}},{"identifier":{"@type":"PMID","@value":"38017649"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The association between trypsin‐like protease activity in the oral cavity and kidney function in Japanese workers"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To evaluate the association between trypsin‐like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>This cross‐sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue‐swab TLP activity was quantified as <jats:italic>a</jats:italic>* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the <jats:italic>a</jats:italic>* value with three eGFR categories: ≥90, 60–89 and <60 mL/min/1.73 m<jats:sup>2</jats:sup>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60–89 (63.8%) and <60 mL/min/1.73 m<jats:sup>2</jats:sup> (4.6%). After adjusting for potential confounders, the <jats:italic>a</jats:italic>* value was found to be significantly associated with reduced kidney function. The multivariable‐adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02–1.22) per unit increase in the <jats:italic>a</jats:italic>* value.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Higher TLP activity was associated with reduced kidney function in Japanese workers.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021389815656706","@type":"Researcher","foaf:name":[{"@value":"Masanori Iwasaki"}],"jpcoar:affiliationName":[{"@value":"Dental Center for Regional Medical Survey Kyushu Dental University  Kitakyushu Fukuoka Japan"},{"@value":"Department of Preventive Dentistry, Faculty of Dental Medicine and Graduate School of Dental Medicine Hokkaido University  Sapporo Hokkaido Japan"},{"@value":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi‐Ku Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420003854339946112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30882667"},{"@type":"NRID","@value":"1000030882667"}],"foaf:name":[{"@value":"Maki Inoue"}],"jpcoar:affiliationName":[{"@value":"Dental Center for Regional Medical Survey Kyushu Dental University  Kitakyushu Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276170758400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10453630"},{"@type":"NRID","@value":"1000010453630"},{"@type":"NRID","@value":"9000004730675"},{"@type":"NRID","@value":"9000409880083"},{"@type":"NRID","@value":"9000258388463"},{"@type":"NRID","@value":"9000258313345"},{"@type":"NRID","@value":"9000258316628"},{"@type":"NRID","@value":"9000315142062"},{"@type":"NRID","@value":"9000410312836"},{"@type":"NRID","@value":"9000258316643"},{"@type":"NRID","@value":"9000408594197"},{"@type":"NRID","@value":"9000258310748"},{"@type":"NRID","@value":"9000319549160"},{"@type":"NRID","@value":"9000412131774"},{"@type":"NRID","@value":"9000258388474"},{"@type":"NRID","@value":"9000258315579"},{"@type":"NRID","@value":"9000415183934"},{"@type":"NRID","@value":"9000414726072"},{"@type":"NRID","@value":"9000257942437"},{"@type":"NRID","@value":"9000399371453"},{"@type":"NRID","@value":"9000001797625"},{"@type":"NRID","@value":"9000308728112"},{"@type":"NRID","@value":"9000258312445"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/usuimic"}],"foaf:name":[{"@value":"Michihiko Usui"}],"jpcoar:affiliationName":[{"@value":"Division of Periodontology Kyushu Dental University  Kitakyushu Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021389815656708","@type":"Researcher","foaf:name":[{"@value":"Wataru Ariyoshi"}],"jpcoar:affiliationName":[{"@value":"Division of Infections and Molecular Biology Kyushu Dental University  Kitakyushu Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021389815656707","@type":"Researcher","foaf:name":[{"@value":"Keisuke Nakashima"}],"jpcoar:affiliationName":[{"@value":"Division of Periodontology Kyushu Dental University  Kitakyushu Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021389815656709","@type":"Researcher","foaf:name":[{"@value":"Yoshie Nagai‐Yoshioka"}],"jpcoar:affiliationName":[{"@value":"Division of Infections and Molecular Biology Kyushu Dental University  Kitakyushu Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021389815656704","@type":"Researcher","foaf:name":[{"@value":"Tatsuji Nishihara"}],"jpcoar:affiliationName":[{"@value":"Dental Center for Regional Medical Survey Kyushu Dental University  Kitakyushu Fukuoka Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03036979"},{"@type":"EISSN","@value":"1600051X"}],"prism:publicationName":[{"@value":"Journal of Clinical Periodontology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2023-11-28","prism:volume":"51","prism:number":"3","prism:startingPage":"265","prism:endingPage":"273"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcpe.13908"}],"createdAt":"2023-11-29","modifiedAt":"2024-02-16","project":[{"@id":"https://cir.nii.ac.jp/crid/1040010457607791872","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K10331"},{"@type":"JGN","@value":"JP22K10331"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K10331/"}],"notation":[{"@language":"ja","@value":"多歯時代の歯周病：機械学習による将来予測とスクリーニングスコアの開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1040287907239564032","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K17201"},{"@type":"JGN","@value":"JP21K17201"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K17201/"}],"notation":[{"@language":"ja","@value":"多項目検出簡易型歯周病検査キットの開発と成人歯科検診への応用"},{"@language":"en","@value":"Development of simple periodontal disease detection device and its application to measure the states of adult periodontitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040573407543504768","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K09970"},{"@type":"JGN","@value":"JP22K09970"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09970/"}],"notation":[{"@language":"ja","@value":"歯根膜細胞スフェロイドの幹細胞性・骨分化能亢進のメカニズム解明"},{"@language":"en","@value":"Mechanism of enhanced stemness and  osteogenesis of periodontal ligament cell spheroids"}]},{"@id":"https://cir.nii.ac.jp/crid/1040577277054376448","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K16233"},{"@type":"JGN","@value":"JP23K16233"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K16233/"}],"notation":[{"@language":"ja","@value":"デジタル表示型歯周病簡易型検査機器を用いた生活習慣病に関する疫学的研究の展開"},{"@language":"en","@value":"Epidemiological studies on lifestyle-related diseases using a periodontitis test device with digital display"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144509128832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glomerulosclerosis in aging humans is not influenced by gender"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430641750144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of a Novel Immunochromatographic Device for Detecting Porphyromonas gingivalis in Patients with Periodontal Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619192903552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645722121600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between chronic kidney disease and 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Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equations for estimated GFR from serum creatinine in Japan. American journal of kidney diseases: the official journal of the"},{"@value":"Revised equations for estimating glomerular filtration rate (GFR) from serum creatinine in Japan"},{"@value":"Hishida A; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimating GFR. Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR"},{"@value":"Japanese equation for estimated GFR"},{"@value":"Revised equation for estimating glomerular filtration rate (GFR) from serum creatinin in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892108623744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prediction of cardiovascular outcome by estimated glomerular filtration rate among high-risk patients : a Thai nationwide cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842055085440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New measures against chronic kidney diseases in Japan since 2018"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/jcpe.13908"},{"@type":"KAKEN","@value":"PRODUCT-24932351"},{"@type":"KAKEN","@value":"PRODUCT-24820328"},{"@type":"KAKEN","@value":"PRODUCT-25691465"},{"@type":"KAKEN","@value":"PRODUCT-25058521"},{"@type":"OPENAIRE","@value":"doi_dedup___::cf483a22e56963baebaf7b4b17c3b205"},{"@type":"CROSSREF","@value":"10.3390/ijms25158187_references_DOI_4cGYLAJjqkoAxrZpYuM2kDr2N9L"}]}