{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390563594752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2147/opth.s298310"}},{"identifier":{"@type":"URI","@value":"https://www.dovepress.com/getfile.php?fileID=67539"}},{"identifier":{"@type":"HANDLE","@value":"11343/304631"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Associations of ARMS2 and CFH Gene Polymorphisms with Neovascular Age-Related Macular Degeneration"}],"description":[{"notation":[{"@value":"<h4>Purpose</h4>This study aimed to determine the association of <i>ARMS2</i> A69S, <i>ARMS2</i> del443ins54, and <i>CFH</i> Y402H polymorphisms with neovascular age-related macular degeneration (nAMD) for the first time in an Indonesian population.<h4>Patients and methods</h4>Our case-control study involved 104 nAMD and 100 control subjects. AMD diagnosis was evaluated by retinal specialists based on color fundus photography and optical coherence tomography. The polymorphisms on <i>CFH</i> Y402H and <i>ARMS2</i> A69S were analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP), whereas <i>ARMS2</i> del443ins54 was evaluated by PCR-based assay.<h4>Results</h4>Significant allelic associations with nAMD were detected on all polymorphisms (P<0.05), with stronger association with the <i>ARMS2</i> A69S (OR 3.13; 95% CI 2.08-4.71; P<0.001) and <i>ARMS2</i> del443ins54 (OR 3.28; 95% CI 2.17-4.95; P<0.001) polymorphisms than with <i>CFH</i> Y402H (OR 2.08; 95% CI 1.08-3.99; P=0.028). Genotype analysis showed a statistical difference between nAMD and the control group for all polymorphisms (P<0.05). However, the association with nAMD was weaker for <i>CFH</i> Y402H (P=0.043) than for <i>ARMS2</i> A69S and <i>ARMS2</i> del443ins54 (P<0.001). A significant interaction between <i>ARMS2</i> A69S and hypertension was documented (OR 9.53; 95% CI 3.61-25.1; P<0.001).<h4>Conclusion</h4>Our findings indicate that <i>ARMS2</i> A69S and <i>ARMS2</i> del443ins54 polymorphisms are strongly associated with the risk of nAMD for the first time in an Indonesian population. The risk of nAMD increased when the presence of risk alleles from <i>ARMS2</i> A69S was combined with the presence of hypertension."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390563594782","@type":"Researcher","foaf:name":[{"@value":"Supanji Supanji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594788","@type":"Researcher","foaf:name":[{"@value":"Dewi Fathin Romdhoniyyah"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594625","@type":"Researcher","foaf:name":[{"@value":"Muhammad Bayu Sasongko"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594630","@type":"Researcher","foaf:name":[{"@value":"Angela Nurini Agni"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594759","@type":"Researcher","foaf:name":[{"@value":"Firman Setya Wardhana"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594626","@type":"Researcher","foaf:name":[{"@value":"Tri Wahyu Widayanti"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594764","@type":"Researcher","foaf:name":[{"@value":"Muhammad Eko Prayogo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594765","@type":"Researcher","foaf:name":[{"@value":"Ayudha Bahana Ilham Perdamaian"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594773","@type":"Researcher","foaf:name":[{"@value":"Aninditta Dianratri"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390563594777","@type":"Researcher","foaf:name":[{"@value":"Masashi Kawaichi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801184807680","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30263445"},{"@type":"NRID","@value":"1000030263445"}],"foaf:name":[{"@value":"Chio Oka"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"11775483"}],"prism:publicationName":[{"@value":"Clinical Ophthalmology"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2021-03","prism:volume":"Volume 15","prism:startingPage":"1101","prism:endingPage":"1108"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/3.0/"],"url":[{"@id":"https://www.dovepress.com/getfile.php?fileID=67539"}],"createdAt":"2021-03-10","modifiedAt":"2021-03-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Ophthalmology","dc:title":"Ophthalmology"},{"@id":"https://cir.nii.ac.jp/all?q=616","dc:title":"616"},{"@id":"https://cir.nii.ac.jp/all?q=arms2","dc:title":"arms2"},{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20Ophthalmology","dc:title":"Clinical Ophthalmology"},{"@id":"https://cir.nii.ac.jp/all?q=cfh","dc:title":"cfh"},{"@id":"https://cir.nii.ac.jp/all?q=RE1-994","dc:title":"RE1-994"},{"@id":"https://cir.nii.ac.jp/all?q=age-related%20macular%20degeneration","dc:title":"age-related macular degeneration"},{"@id":"https://cir.nii.ac.jp/all?q=polymorphism","dc:title":"polymorphism"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782019978240","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K09950"},{"@type":"JGN","@value":"JP19K09950"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09950/"}],"notation":[{"@language":"ja","@value":"加齢黄斑変性の発症に関わるセリンプロテアーゼHtrA1の基質の同定と機能解析"},{"@language":"en","@value":"Functional analysis of AMD  related serine protease HtrA1"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144539636352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age‐related macular degeneration in a Korean population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870121318656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polypoidal Choroidal 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