{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390567511296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.cca.2023.117521"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0009898123003236?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0009898123003236?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"37597644"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Relationship between the cholesterol and triglyceride content of lipoprotein subclasses and carotid intima-media thickness: A cross-sectional population-based study"}],"description":[{"notation":[{"@value":"The association between lipoprotein subclasses and carotid intima-media thickness (cIMT) progression has yet to be fully evaluated. We assessed which lipoprotein subclasses were associated with maximum cIMT levels in the general population.In this study, cholesterol and triglyceride content of 20 lipoprotein subclasses were analyzed using gel permeation high-performance liquid chromatography (GP-HPLC) in 864 Japanese women and men (mean age 57 y, free of chronic liver or kidney diseases and off lipid-lowering, hormone replacement, or adrenocorticosteroid medications). Univariate and multivariate regression analyses and univariate and partial correlation analyses were performed to examine the relationships between lipoprotein subclasses and maximum cIMT levels.After adjusting for age, sex, systolic blood pressure, smoking, diabetes, and anti-hypertensive agents, elevated low-density lipoprotein (LDL)-2 and -3 cholesterol (particle diameter 25.5 nm and 23.0 nm, respectively; medium and small LDL) were associated with higher maximum cIMT levels in both women and men (all p for trend  0.05). These associations were significant even after participants taking anti-diabetic or anti-hypertensive agents were excluded. No significant associations were found between any triglyceride subclasses and maximum cIMT levels.Smaller LDL particle cholesterol values are the most atherogenic lipoprotein parameter."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390567511302","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Ikezaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511305","@type":"Researcher","foaf:name":[{"@value":"Norihiro Furusyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511181","@type":"Researcher","foaf:name":[{"@value":"Masumi Ai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511184","@type":"Researcher","foaf:name":[{"@value":"Mitsuyo Okazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511192","@type":"Researcher","foaf:name":[{"@value":"Takuji Kohzuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511301","@type":"Researcher","foaf:name":[{"@value":"Jun Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511170","@type":"Researcher","foaf:name":[{"@value":"Nobuyuki Shimono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390567511195","@type":"Researcher","foaf:name":[{"@value":"Ernst J. Schaefer"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00098981"}],"prism:publicationName":[{"@value":"Clinica Chimica Acta"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2023-08","prism:volume":"548","prism:startingPage":"117521"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0009898123003236?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0009898123003236?httpAccept=text/plain"}],"createdAt":"2023-08-17","modifiedAt":"2025-09-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Cholesterol","dc:title":"Cholesterol"},{"@id":"https://cir.nii.ac.jp/all?q=Lipoproteins","dc:title":"Lipoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Cholesterol,%20LDL","dc:title":"Cholesterol, LDL"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Carotid%20Intima-Media%20Thickness","dc:title":"Carotid Intima-Media Thickness"},{"@id":"https://cir.nii.ac.jp/all?q=Triglycerides","dc:title":"Triglycerides"},{"@id":"https://cir.nii.ac.jp/all?q=Antihypertensive%20Agents","dc:title":"Antihypertensive Agents"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040573407541783424","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22H04923"},{"@type":"JGN","@value":"JP22H04923"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04923/"}],"notation":[{"@language":"ja","@value":"コホート・生体試料支援プラットフォーム"},{"@language":"en","@value":"Platform of  Supporting  Cohort Study and Biospecimen Analysis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360021394470836992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atherosclerotic cardiovascular disease risk and small dense low-density lipoprotein cholesterol in men, women, African Americans and non-African Americans: The pooling project"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021394470860800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Small dense low-density lipoprotein: Analytical 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Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045331144576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An International Atherosclerosis Society Position Paper: Global recommendations for the management of dyslipidemia-Full report"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520408874368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HDL Particle Size Is a Critical Determinant of ABCA1-Mediated Macrophage Cellular Cholesterol Export"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520625794816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Small, Dense High-Density Lipoprotein-3 Particles Are Enriched in Negatively Charged Phospholipids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520726788224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HDL Particle Measurement: 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unanswered questions"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269412025088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiovascular Risk Factors in Childhood and Carotid Artery Intima-Media Thickness in Adulthood"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270267630336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study"}]},{"@id":"https://cir.nii.ac.jp/crid/1370021390567511179","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High density lipoprotein cholesterol and mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204421465216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Carotid Ultrasound 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