{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390570142592.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-023-43739-5"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-023-43739-5.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-023-43739-5"}},{"identifier":{"@type":"PMID","@value":"38086807"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"CENP-A and CENP-B collaborate to create an open centromeric chromatin state"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle microtubules during cell division. The DNA-binding centromeric protein CENP-B is involved in maintaining centromere stability and, together with CENP-A, shapes the centromeric chromatin state. The nanoscale organization of centromeric chromatin is not well understood. Here, we use single-molecule fluorescence and cryoelectron microscopy (cryoEM) to show that CENP-A incorporation establishes a dynamic and open chromatin state. The increased dynamics of CENP-A chromatin create an opening for CENP-B DNA access. In turn, bound CENP-B further opens the chromatin fiber structure and induces nucleosomal DNA unwrapping. Finally, removal of CENP-A increases CENP-B mobility in cells. Together, our studies show that the two centromere-specific proteins collaborate to reshape chromatin structure, enabling the binding of centromeric factors and establishing a centromeric chromatin state.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390570142740","@type":"Researcher","foaf:name":[{"@value":"Harsh Nagpal"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142599","@type":"Researcher","foaf:name":[{"@value":"Ahmad Ali-Ahmad"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142765","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Hirano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142764","@type":"Researcher","foaf:name":[{"@value":"Wei Cai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142725","@type":"Researcher","foaf:name":[{"@value":"Mario Halic"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326233703680","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60321600"},{"@type":"NRID","@value":"1000060321600"},{"@type":"NRID","@value":"9000016808738"},{"@type":"NRID","@value":"9000410653283"},{"@type":"NRID","@value":"9000019108791"},{"@type":"NRID","@value":"9000018395410"},{"@type":"NRID","@value":"9000364830782"},{"@type":"NRID","@value":"9000022904665"},{"@type":"NRID","@value":"9000022904659"},{"@type":"NRID","@value":"9000022904672"},{"@type":"NRID","@value":"9000003008265"},{"@type":"NRID","@value":"9000409886897"},{"@type":"NRID","@value":"9000010148483"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/fukagawa_tatsuo"}],"foaf:name":[{"@value":"Tatsuo Fukagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142600","@type":"Researcher","foaf:name":[{"@value":"Nikolina Sekulić"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390570142861","@type":"Researcher","foaf:name":[{"@value":"Beat Fierz"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2023-12-12","prism:volume":"14","prism:number":"1"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-023-43739-5.pdf"},{"@id":"https://www.nature.com/articles/s41467-023-43739-5"}],"createdAt":"2023-12-12","modifiedAt":"2023-12-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Crystal-Structure","dc:title":"Crystal-Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetochore","dc:title":"Kinetochore"},{"@id":"https://cir.nii.ac.jp/all?q=Null%20Mice","dc:title":"Null Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Nucleosome","dc:title":"Nucleosome"},{"@id":"https://cir.nii.ac.jp/all?q=Protein","dc:title":"Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Reveals","dc:title":"Reveals"},{"@id":"https://cir.nii.ac.jp/all?q=Complex","dc:title":"Complex"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence","dc:title":"Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Cryo-Em%20Structure","dc:title":"Cryo-Em Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Dna-Binding","dc:title":"Dna-Binding"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040010457588354560","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22H04692"},{"@type":"JGN","@value":"JP22H04692"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04692/"}],"notation":[{"@language":"ja","@value":"セントロメアの維持・形成に関与する非ゲノム情報"}]},{"@id":"https://cir.nii.ac.jp/crid/1040014327101797504","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23H04282"},{"@type":"JGN","@value":"JP23H04282"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04282/"}],"notation":[{"@language":"ja","@value":"セントロメアモダリティの理解"}]},{"@id":"https://cir.nii.ac.jp/crid/1040578282915200000","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K18113"},{"@type":"JGN","@value":"JP23K18113"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18113/"}],"notation":[{"@language":"ja","@value":"進化的多様性を持つセントロメア構成の理解"}]},{"@id":"https://cir.nii.ac.jp/crid/1040854882544783232","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22H00408"},{"@type":"JGN","@value":"JP22H00408"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00408/"}],"notation":[{"@language":"ja","@value":"セントロメア/動原体機能の包括的理解"},{"@language":"en","@value":"Comprehensive understanding for centromeres and kinetochores"}]},{"@id":"https://cir.nii.ac.jp/crid/1041693800952414592","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20H05891"},{"@type":"JGN","@value":"JP20H05891"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05891/"}],"notation":[{"@language":"ja","@value":"生きた細胞や組織における散乱・揺らぎ計測と制御"},{"@language":"en","@value":"Measurement and control of scattering and optical fluctuation in living cells and tissues"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050004953502519424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome"},{"@value":"Cryo‐EM Structures of Centromeric Tri‐Nucleosomes Containing a Central CENP‐A 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Nucleosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046547375872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A two-step mechanism for epigenetic specification of centromere identity and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518892815744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sequence motifs and free energies of selected natural and non-natural nucleosome positioning DNA sequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519018142336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Centromere Protein B Null Mice are Mitotically and Meiotically Normal but Have Lower Body and Testis Weights"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519967622656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<scp>CENP</scp>\n                    ‐C unwraps the human\n                    <scp>CENP</scp>\n                    ‐A 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