{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390574715264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/jcm12103475"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2077-0383/12/10/3475/pdf"}},{"identifier":{"@type":"PMID","@value":"37240582"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Retinal Microvascular Changes after Intravitreal Triamcinolone Acetonide in Diabetic Macular Edema"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Intravitreal injection of triamcinolone acetonide (TA) is essential for clinical treatment in patients who insufficiently respond to vascular endothelial factor inhibitors for diabetic macular edema (DME). The aim of this study was to investigate microvascular changes treated with TA using optical coherence tomography angiography (OCTA). After TA in twelve eyes of eleven patients with central retinal thickness (CRT), there was a 20% or more reduction observed. Visual acuity, the number of microaneurysms, vessel density, and the foveal avascular zone (FAZ) area were compared before and at 2 months after TA. At baseline, the number of microaneurysms was 2.1 ± 1.1 in the superficial capillary plexuses (SCP) and 2.0 ± 1.1 in the deep capillary plexuses (DCP), with a significant decrease post-treatment to 1.0 ± 1.0 for SCP and 0.8 ± 0.8 for DCP (SCP; p = 0.018, DCP; p = 0.008). There was significant enlargement of the FAZ area from 0.28 ± 0.11 mm2 to 0.32 ± 0.14 mm2 (p = 0.041). There was no significant difference in the visual acuity and vessel density of SCP and DCP. Results indicated that OCTA was useful for the evaluation of qualitative and morphological retinal microcirculation and that intravitreal TA may decrease microaneurysms.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390574706701","@type":"Researcher","foaf:name":[{"@value":"Miho Nozaki"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"@value":"Department of Ophthalmology, Nagoya City University East Medical Center, Nagoya 464-8547, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390574706821","@type":"Researcher","foaf:name":[{"@value":"Tsutomu Yasukawa"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390574706692","@type":"Researcher","foaf:name":[{"@value":"Aki Kato"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390574715275","@type":"Researcher","foaf:name":[{"@value":"Fusae Kato"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Toyota Kosei Hospital, Toyota 470-0396, Japan"},{"@value":"Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20770383"}],"prism:publicationName":[{"@value":"Journal of Clinical Medicine"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2023-05-15","prism:volume":"12","prism:number":"10","prism:startingPage":"3475"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2077-0383/12/10/3475/pdf"}],"createdAt":"2023-05-16","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=diabetes;%20diabetic%20macular%20edema;%20optical%20coherence%20tomography%20angiography;%20vessel%20density;%20intravitreal%20triamcinolone%20acetonide;%20microaneurysms;%20acetonide","dc:title":"diabetes; diabetic macular edema; optical coherence tomography angiography; vessel density; intravitreal triamcinolone acetonide; microaneurysms; acetonide"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040008389832939008","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K20974"},{"@type":"JGN","@value":"JP21K20974"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K20974/"}],"notation":[{"@language":"ja","@value":"VEGF阻害薬が無効な糖尿病黄斑浮腫のバイオマーカーの確立および新規治療開発"},{"@language":"en","@value":"Establishment of biomarkers and development of new treatment for diabetic macular edema  when  VEGF inhibitors  are ineffective."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145270431104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 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