{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390738730880.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adhm.202301335"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202301335"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Creating and Transferring an Innervated, Vascularized Muscle Flap Made from an Elastic, Cellularized Tissue Construct Developed In Situ"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Reanimating facial structures following paralysis and muscle loss is a surgical objective that would benefit from improved options for harvesting appropriately sized muscle flaps. The objective of this study is to apply electrohydrodynamic processing to generate a cellularized, elastic, biocomposite scaffold that could develop and mature as muscle in a prepared donor site in vivo, and then be transferred as a thin muscle flap with a vascular and neural pedicle. First, an effective extracellular matrix (ECM) gel type is selected for the biocomposite scaffold from three types of ECM combined with poly(ester urethane)urea microfibers and evaluated in rat abdominal wall defects. Next, two types of precursor cells (muscle‐derived and adipose‐derived) are compared in constructs placed in rat hind limb defects for muscle regeneration capacity. Finally, with a construct made from dermal ECM and muscle‐derived stem cells, protoflaps are implanted in one hindlimb for development and then microsurgically transferred as a free flap to the contralateral limb where stimulated muscle function is confirmed. This construct generation and in vivo incubation procedure may allow the generation of small‐scale muscle flaps appropriate for transfer to the face, offering a new strategy for facial reanimation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390738731136","@type":"Researcher","foaf:name":[{"@value":"Hideyoshi Sato"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738731137","@type":"Researcher","foaf:name":[{"@value":"Keishi Kohyama"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738731008","@type":"Researcher","foaf:name":[{"@value":"Takafumi Uchibori"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738731010","@type":"Researcher","foaf:name":[{"@value":"Keisuke Takanari"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738731138","@type":"Researcher","foaf:name":[{"@value":"Johnny Huard"}],"jpcoar:affiliationName":[{"@value":"Center for Regenerative Sports Medicine Steadman Philippon Research Institute  181 West Meadow Dr. Vail CO 81657 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738730881","@type":"Researcher","foaf:name":[{"@value":"Stephen F. Badylak"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"},{"@value":"Department of Surgery University of Pittsburgh  200 Lothrop Street Pittsburgh PA 15213 USA"},{"@value":"Department of Bioengineering University of Pittsburgh  3700 O'Hara Street, Benedum Hall of Engineering Pittsburgh PA 15261 USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738731009","@type":"Researcher","foaf:name":[{"@value":"Antonio D'Amore"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"},{"@value":"Department of Surgery University of Pittsburgh  200 Lothrop Street Pittsburgh PA 15213 USA"},{"@value":"Department of Bioengineering University of Pittsburgh  3700 O'Hara Street, Benedum Hall of Engineering Pittsburgh PA 15261 USA"},{"@value":"Fondazione Ri.MED  Palermo 90133 Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390738730880","@type":"Researcher","foaf:name":[{"@value":"William R. Wagner"}],"jpcoar:affiliationName":[{"@value":"McGowan Institute for Regenerative Medicine University of Pittsburgh  450 Technology Dr. Pittsburgh PA 15219 USA"},{"@value":"Department of Surgery University of Pittsburgh  200 Lothrop Street Pittsburgh PA 15213 USA"},{"@value":"Department of Bioengineering University of Pittsburgh  3700 O'Hara Street, Benedum Hall of Engineering Pittsburgh PA 15261 USA"},{"@value":"Department of Chemical Engineering University of Pittsburgh  3700 O'Hara Street, Benedum Hall of Engineering Pittsburgh PA 15261 USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"21922640"},{"@type":"EISSN","@value":"21922659"}],"prism:publicationName":[{"@value":"Advanced Healthcare Materials"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2023-08-04","prism:volume":"12","prism:number":"29"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202301335"}],"createdAt":"2023-07-27","modifiedAt":"2025-10-06","project":[{"@id":"https://cir.nii.ac.jp/crid/1040014327097636736","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K09075"},{"@type":"JGN","@value":"JP23K09075"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K09075/"}],"notation":[{"@language":"ja","@value":"自家軟骨移植の代用としてのu-HA/PLLAの可能性"},{"@language":"en","@value":"Possibility of u-HA/PLLA as a substitute for autologous cartilage transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256981733888","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K16991"},{"@type":"JGN","@value":"JP18K16991"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16991/"}],"notation":[{"@language":"ja","@value":"生体親和性マテリアルを用いた、糖尿病性潰瘍の新規治療法の開発"},{"@language":"en","@value":"Investigation of new treatment for diabetic ulcer with the biodegradable scaffold"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143999618176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly(ester‐urethane)ureas based on poly(caprolactone) and putrescine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144257654784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering vascularized skeletal muscle tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144826218624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The chemokine system in diverse forms of macrophage activation and polarization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017285891337216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021397033049984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electrodiagnostic Evaluation of Individuals Implanted With Extracellular Matrix for the Treatment of Volumetric Muscle Injury: Case Series"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619204029568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Natural Hepatocyte Growth Factor/Scatter Factor Autocrine Loop in Myoblast Cells and the Effect of the Constitutive<i>Met</i>Kinase Activation on Myogenic Differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619564064384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Flap Prefabrication in the Head and Neck: A 10-Year Experience"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619588337152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Collagen and fibronectin in a healing skeletal muscle injury. 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