{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390767936000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajprenal.00011.2024"}},{"identifier":{"@type":"URI","@value":"https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00011.2024"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Patients frequently present with acute kidney injury or abnormal urinary findings after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated how the kidneys respond during SARS-CoV-2 infection using a murine coronavirus disease 2019 (COVID-19) model and showed that Janus kinase-mediated endogenous antiviral activity protects against kidney injury in the early phase of SARS-CoV-2 infection. These findings provide valuable insights into the renal pathophysiology of COVID-19. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390767936007","@type":"Researcher","foaf:name":[{"@value":"Hibiki Sakai"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936002","@type":"Researcher","foaf:name":[{"@value":"Hiroyasu Kamuro"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936001","@type":"Researcher","foaf:name":[{"@value":"Nagisa Tokunoh"}],"jpcoar:affiliationName":[{"@value":"Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Research Foundation for Microbial Diseases, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936006","@type":"Researcher","foaf:name":[{"@value":"Takeshi Izawa"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Pathology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420569149890946048","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90908203"},{"@type":"NRID","@value":"1000090908203"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shigeyuki.tamiya"}],"foaf:name":[{"@value":"Shigeyuki Tamiya"}],"jpcoar:affiliationName":[{"@value":"Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Department of Microbiology and Immunology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936008","@type":"Researcher","foaf:name":[{"@value":"Ayaha Yamamoto"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936009","@type":"Researcher","foaf:name":[{"@value":"Shota Tanaka"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936005","@type":"Researcher","foaf:name":[{"@value":"Daisuke Okuzaki"}],"jpcoar:affiliationName":[{"@value":"Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936011","@type":"Researcher","foaf:name":[{"@value":"Chikako Ono"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936004","@type":"Researcher","foaf:name":[{"@value":"Yoshiharu Matsuura"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"},{"@value":"Center for Advanced Modalities and DDS, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936003","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki Okada"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936010","@type":"Researcher","foaf:name":[{"@value":"Yasuo Yoshioka"}],"jpcoar:affiliationName":[{"@value":"Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Research Foundation for Microbial Diseases, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"},{"@value":"Center for Advanced Modalities and DDS, Osaka University, Osaka, Japan"},{"@value":"Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936013","@type":"Researcher","foaf:name":[{"@value":"Yasushi Fujio"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"},{"@value":"Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390767936000","@type":"Researcher","foaf:name":[{"@value":"Masanori Obana"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"},{"@value":"Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan"},{"@value":"Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan"},{"@value":"Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan"},{"@value":"Radioisotope Research Center, Institute for Radiation Sciences, Osaka University, Osaka, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1931857X"},{"@type":"EISSN","@value":"15221466"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Renal Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2024-06-01","prism:volume":"326","prism:number":"6","prism:startingPage":"F931","prism:endingPage":"F941"},"reviewed":"false","url":[{"@id":"https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00011.2024"}],"createdAt":"2024-04-18","modifiedAt":"2024-05-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040291932590924544","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K15276"},{"@type":"JGN","@value":"JP22K15276"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15276/"}],"notation":[{"@language":"ja","@value":"マイコプラズマニューモニエに起因した気管支喘息の発症機序の解明"},{"@language":"en","@value":"Elucidation of the pathogenesis of bronchial asthma caused by Mycoplasma pneumoniae"}]},{"@id":"https://cir.nii.ac.jp/crid/1040862776834607360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K27671"},{"@type":"JGN","@value":"JP23K27671"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27671/"}],"notation":[{"@language":"ja","@value":"正常組織に影響を与えない癌幹細胞標的分子の探索"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143773143680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired type I interferon activity and inflammatory 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