{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390768066432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1172/jci.insight.165944"}},{"identifier":{"@type":"URI","@value":"https://insight.jci.org/articles/view/165944/files/pdf"}},{"identifier":{"@type":"PMID","@value":"37463055"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"N-acetylglucosamine-6-O sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota"}],"description":[{"notation":[{"@value":"Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the regulation of host immune systems; hence, its dysregulation is a hallmark of metabolic disease and intestinal inflammation. However, the mechanism by which intestinal mucins control the gut microbiota as well as disease phenotypes remains nebulous. Herein, we report that N-acetylglucosamine (GlcNAc)-6-O sulfation of O-glycans on intestinal mucins performs a protective role against obesity and intestinal inflammation. Chst4-/- mice, lacking GlcNAc-6-O sulfation of the mucin O-glycans, showed significant weight gain and increased susceptibility to dextran sodium sulfate-induced colitis as well as colitis-associated cancer accompanied by significantly reduced immunoglobulin A (IgA) production caused by an impaired T follicular helper cell-mediated IgA response. Interestingly, the protective effects of GlcNAc-6-O sulfation against obesity and intestinal inflammation depend on the gut microbiota, evidenced by the modulation of the gut microbiota by cohousing or microbiota transplantation reversing disease phenotypes and IgA production. Collectively, our findings provide insight into the significance of host glycosylation, more specifically GlcNAc-6-O sulfation on intestinal mucins, in protecting against obesity and intestinal inflammation via regulation of the gut microbiota."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390768066433","@type":"Researcher","foaf:name":[{"@value":"Hirohito Abo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066438","@type":"Researcher","foaf:name":[{"@value":"Maki Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066432","@type":"Researcher","foaf:name":[{"@value":"Akihito Harusato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066437","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Imura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066304","@type":"Researcher","foaf:name":[{"@value":"Timothy L. Denning"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066434","@type":"Researcher","foaf:name":[{"@value":"Kohta Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066436","@type":"Researcher","foaf:name":[{"@value":"Aoi Muraki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768066435","@type":"Researcher","foaf:name":[{"@value":"Hiroto Kawashima"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"23793708"}],"prism:publicationName":[{"@value":"JCI Insight"}],"dc:publisher":[{"@value":"American Society for Clinical Investigation"}],"prism:publicationDate":"2023-08-22","prism:volume":"8","prism:number":"16"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://insight.jci.org/articles/view/165944/files/pdf"}],"createdAt":"2023-07-18","modifiedAt":"2023-08-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Gastroenterology","dc:title":"Gastroenterology"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Mucins","dc:title":"Mucins"},{"@id":"https://cir.nii.ac.jp/all?q=Acetylglucosamine","dc:title":"Acetylglucosamine"},{"@id":"https://cir.nii.ac.jp/all?q=Gastrointestinal%20Microbiome","dc:title":"Gastrointestinal Microbiome"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Polysaccharides","dc:title":"Polysaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Obesity","dc:title":"Obesity"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research 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niche"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318942769408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319756506752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319797435136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320328620032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial 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