{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390768559232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/s41182-024-00595-3"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/s41182-024-00595-3.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1186/s41182-024-00595-3/fulltext.html"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The overlap of accessory virulence factors and multidrug resistance among clinical and surveillance Klebsiella pneumoniae isolates from a neonatal intensive care unit in Nepal: a single-centre experience in a resource-limited setting"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>There is a lack of data on the characteristics of overlap between acquired antimicrobial resistance and virulence factors in <jats:italic>Klebsiella pneumoniae</jats:italic> in high-risk settings, especially with the inclusion of surveillance isolates along with the clinical. We investigated <jats:italic>K. pneumoniae</jats:italic> isolates, from a neonatal intensive care unit (NICU) in Nepal, for the presence of both accessory virulence factors and acquired antimicrobial resistance.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>Thirty-eight clinical and nineteen surveillance <jats:italic>K. pneumoniae</jats:italic> isolates obtained between January 2017 and August 2022 in the NICU of Siddhi Memorial Hospital, Bhaktapur, Nepal were investigated with antimicrobial susceptibility testing, PCR-based detection of β-lactamases and virulence factors, and genetic similarity by ERIC–PCR.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p><jats:italic>K. pneumoniae</jats:italic> was found positive in 37/85 (43.5%) blood culture-positive neonatal bloodstream infections, 34/954 (3.6%) patient surveillance cultures, and 15/451 (3.3%) environmental surveillance samples. Among 57 isolates analyzed in this study, we detected multidrug resistance in 37/57 (64.9%), which was combined with at least one accessory virulence factor in 21/37 (56.8%). This overlap was mostly among β-lactamase producing isolates with accessory mechanisms of iron acquisition. These isolates displayed heterogenous ERIC–PCR patterns suggesting genetic diversity.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>The clinical significance of this overlap between acquired antimicrobial resistance and accessory virulence genes in <jats:italic>K. pneumoniae</jats:italic> needs further investigation. Better resource allocation is necessary to strengthen infection prevention and control interventions in resource-limited settings.</jats:p>\n              </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390768559235","@type":"Researcher","foaf:name":[{"@value":"Raj Kumar Shrestha"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559242","@type":"Researcher","foaf:name":[{"@value":"Dhruba Shrestha"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559239","@type":"Researcher","foaf:name":[{"@value":"Ajaya Jang Kunwar"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559238","@type":"Researcher","foaf:name":[{"@value":"Sandeep Thapa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559111","@type":"Researcher","foaf:name":[{"@value":"Nipun Shrestha"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559106","@type":"Researcher","foaf:name":[{"@value":"Bhim Gopal Dhoubhadel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390768559240","@type":"Researcher","foaf:name":[{"@value":"Christopher M. Parry"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13494147"}],"prism:publicationName":[{"@value":"Tropical Medicine and Health"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2024-04-08","prism:volume":"52","prism:number":"1"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1186/s41182-024-00595-3.pdf"},{"@id":"https://link.springer.com/article/10.1186/s41182-024-00595-3/fulltext.html"}],"createdAt":"2024-04-08","modifiedAt":"2024-04-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Klebsiella%20pneumoniae","dc:title":"Klebsiella pneumoniae"},{"@id":"https://cir.nii.ac.jp/all?q=Extended-spectrum%20%CE%B2-lactamase","dc:title":"Extended-spectrum β-lactamase"},{"@id":"https://cir.nii.ac.jp/all?q=Nepal","dc:title":"Nepal"},{"@id":"https://cir.nii.ac.jp/all?q=Virulence","dc:title":"Virulence"},{"@id":"https://cir.nii.ac.jp/all?q=Arctic%20medicine.%20Tropical%20medicine","dc:title":"Arctic medicine. Tropical medicine"},{"@id":"https://cir.nii.ac.jp/all?q=RC955-962","dc:title":"RC955-962"},{"@id":"https://cir.nii.ac.jp/all?q=Short%20Report","dc:title":"Short Report"},{"@id":"https://cir.nii.ac.jp/all?q=Neonatal%20intensive%20care%20unit%20(NICU)","dc:title":"Neonatal intensive care unit (NICU)"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040573407571232256","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K15924"},{"@type":"JGN","@value":"JP22K15924"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15924/"}],"notation":[{"@language":"ja","@value":"新規アッセイ法による肺炎球菌ワクチン接種幼児の唾液と血清における抗体レベルの比較"},{"@language":"en","@value":"Comparison of antibody levels in saliva and serum among children vaccinated with pneumococcal vaccine using a novel assay method"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144341255168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiplex PCR for detection of acquired carbapenemase genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145403999616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiplex PCR for Detection of Seven Virulence Factors and K1/K2 Capsular Serotypes of Klebsiella pneumoniae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576122247208832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584346475372544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A high‐resolution genomic analysis of multidrug‐resistant hospital outbreaks of\n                    <i>Klebsiella pneumoniae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865817578622848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypervirulent Klebsiella pneumoniae Infections in Pediatric Populations in Beijing (2017–2019)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865818231658112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865821272562176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Patient and Microbial Genomic Factors Associated with Carbapenem-Resistant Klebsiella pneumoniae Extraintestinal Colonization and Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518580615296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469889986688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of Plasmid-Mediated AmpC β-Lactamase Genes in Clinical Isolates by Using Multiplex PCR"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894591681664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Population genomics of Klebsiella pneumoniae"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845176982144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794228771200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution of repetitive DNA sequences in eubacteria and application to finerpriting of bacterial enomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795360409216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GelJ – a tool for analyzing DNA fingerprint gel images"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270013166848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"First Report of the Emergence of CTX-M-Type Extended-Spectrum β-Lactamases (ESBLs) as the Predominant ESBL Isolated in a U.S. Health Care System"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1186/s41182-024-00595-3"},{"@type":"KAKEN","@value":"PRODUCT-25559791"},{"@type":"OPENAIRE","@value":"doi_dedup___::44d79d1818de3d16a1c0432cd5933a25"}]}