{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390769828224.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms24119209"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/24/11/9209/pdf"}},{"identifier":{"@type":"PMID","@value":"37298161"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Effects of Obesity in Old Age on the Basement Membrane of Skeletal Muscle in Mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Obesity and aging are known to affect the skeletal muscles. Obesity in old age may result in a poor basement membrane (BM) construction response, which serves to protect the skeletal muscle, thus making the skeletal muscle more vulnerable. In this study, older and young male C57BL/6J mice were divided into two groups, each fed a high-fat or regular diet for eight weeks. A high-fat diet decreased the relative gastrocnemius muscle weight in both age groups, and obesity and aging individually result in a decline in muscle function. Immunoreactivity of collagen IV, the main component of BM, BM width, and BM-synthetic factor expression in young mice on a high-fat diet were higher than that in young mice on a regular diet, whereas such changes were minimal in obese older mice. Furthermore, the number of central nuclei fibers in obese older mice was higher than in old mice fed a regular diet and young mice fed a high-fat diet. These results suggest that obesity at a young age promotes skeletal muscle BM formation in response to weight gain. In contrast, this response is less pronounced in old age, suggesting that obesity in old age may lead to muscle fragility.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276165389696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60620656"},{"@type":"NRID","@value":"1000060620656"},{"@type":"NRID","@value":"9000414818537"},{"@type":"NRID","@value":"9000412333115"},{"@type":"NRID","@value":"9000318624614"},{"@type":"NRID","@value":"9000283769481"},{"@type":"NRID","@value":"9000318615881"},{"@type":"NRID","@value":"9000412028624"},{"@type":"NRID","@value":"9000414228439"},{"@type":"NRID","@value":"9000403979877"},{"@type":"NRID","@value":"9000362190863"},{"@type":"NRID","@value":"9000319061169"},{"@type":"NRID","@value":"9000403983220"},{"@type":"NRID","@value":"9000263469097"},{"@type":"NRID","@value":"9000263470373"},{"@type":"NRID","@value":"9000412023966"},{"@type":"NRID","@value":"9000319061131"},{"@type":"NRID","@value":"9000257758397"},{"@type":"NRID","@value":"9000414231950"},{"@type":"NRID","@value":"9000409887557"},{"@type":"NRID","@value":"9000397654135"},{"@type":"NRID","@value":"9000263469426"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kanayuji"}],"foaf:name":[{"@value":"Yuji Kanazawa"}],"jpcoar:affiliationName":[{"@value":"Department of Physical Therapy, Hokuriku University, Ishikawa, Kanazawa 920-1180, Japan"},{"@value":"Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, Ohnohigashi, Osakasayama 589-8511, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828230","@type":"Researcher","foaf:name":[{"@value":"Yuri Ikeda-Matsuo"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Pharmacology, Hokuriku University, Ishikawa, Kanazawa 920-1181, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828250","@type":"Researcher","foaf:name":[{"@value":"Hiaki Sato"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Technology and Clinical Engineering, Hokuriku University, Ishikawa, Kanazawa 920-1180, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828239","@type":"Researcher","foaf:name":[{"@value":"Mamoru Nagano"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, Ohnohigashi, Osakasayama 589-8511, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828116","@type":"Researcher","foaf:name":[{"@value":"Satoshi Koinuma"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, Ohnohigashi, Osakasayama 589-8511, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828099","@type":"Researcher","foaf:name":[{"@value":"Tatsuo Takahashi"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Pharmacology, Hokuriku University, Ishikawa, Kanazawa 920-1181, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828232","@type":"Researcher","foaf:name":[{"@value":"Hirokazu Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Synthetic Chemistry, Hokuriku University, Ishikawa, Kanazawa 920-1181, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828104","@type":"Researcher","foaf:name":[{"@value":"Ryo Miyachi"}],"jpcoar:affiliationName":[{"@value":"Department of Physical Therapy, Hokuriku University, Ishikawa, Kanazawa 920-1180, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769828233","@type":"Researcher","foaf:name":[{"@value":"Yasufumi Shigeyoshi"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, Ohnohigashi, Osakasayama 589-8511, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2023-05-24","prism:volume":"24","prism:number":"11","prism:startingPage":"9209"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/24/11/9209/pdf"}],"createdAt":"2023-05-25","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=aging;%20obesity;%20basement%20membrane;%20skeletal%20muscle;%20collagen%20IV","dc:title":"aging; obesity; basement membrane; skeletal muscle; collagen 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