{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390769839616.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms241210133"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/24/12/10133/pdf"}},{"identifier":{"@type":"DOI","@value":"10.20944/preprints202304.1238.v1"}},{"identifier":{"@type":"PMID","@value":"37373277"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390769840005","@type":"Researcher","foaf:name":[{"@value":"Yozo Mitsui"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769840008","@type":"Researcher","foaf:name":[{"@value":"Fumito Yamabe"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769840018","@type":"Researcher","foaf:name":[{"@value":"Shunsuke Hori"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769839746","@type":"Researcher","foaf:name":[{"@value":"Masato Uetani"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769839496","@type":"Researcher","foaf:name":[{"@value":"Hideyuki Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769839881","@type":"Researcher","foaf:name":[{"@value":"Koichi Nagao"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769839513","@type":"Researcher","foaf:name":[{"@value":"Koichi Nakajima"}],"jpcoar:affiliationName":[{"@value":"Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2023-06-14","prism:volume":"24","prism:number":"12","prism:startingPage":"10133"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/24/12/10133/pdf"}],"createdAt":"2023-06-15","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphatidylinositol%203-Kinases","dc:title":"Phosphatidylinositol 3-Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Penile%20Induration","dc:title":"Penile Induration"},{"@id":"https://cir.nii.ac.jp/all?q=Quality%20of%20Life","dc:title":"Quality of Life"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=Penis","dc:title":"Penis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040010457589975936","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K09513"},{"@type":"JGN","@value":"JP22K09513"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09513/"}],"notation":[{"@language":"ja","@value":"泌尿器癌の腫瘍免疫におけるVCANの役割の解明と免疫療法への応用"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144826218624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The chemokine system in diverse forms of macrophage activation and 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