{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021390769997440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms25042093"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/25/4/2093/pdf"}},{"identifier":{"@type":"DOI","@value":"10.20944/preprints202401.1492.v1"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Chemoradiotherapy and Lymph Node Metastasis Affect Dendritic Cell Infiltration and Maturation in Regional Lymph Nodes of Laryngeal Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Dendritic cells (DCs) are the most specialized antigen-presenting cells, and lymph nodes (LNs) play an important role in the DC-mediated T-cell response. We evaluated the infiltration of CD1a-positive DCs (CD1a-DCs), i.e., immature DCs, and S100-positive dendritic cells (S100-DCs), a mixture of immature and mature DCs, in 73 cases of laryngeal cancer and its regional LNs. Among them, 31 patients underwent radiotherapy (RT) or chemoradiotherapy (CRT) prior to surgery. No significant difference was found for CD1a-DC infiltration in the primary tumors, metastatic LNs and non-metastatic LNs, while S100-DCs were significantly fewer in number in the primary tumors and metastatic LNs compared to non-metastatic LNs. The cases which showed a high infiltration of S100-DCs in the metastatic LNs appeared to show a favorable prognosis, although statistical significance was not reached. In the RT/CRT group, the infiltration of the CD1a-DCs and S100-DCs was less in the primary tumors and metastatic LNs compared to the treatment-naive group. Conversely, the RT/CRT group showed higher CD1a-DC and S100-DC numbers in the non-metastatic LNs compared to the treatment-naïve group. Thus, DC maturation in metastatic LNs plays an important role in tumor immunity in laryngeal cancer, and the infiltration of DCs into the primary tumor and metastatic LNs is impaired by RT/CRT.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390769997458","@type":"Researcher","foaf:name":[{"@value":"Kanako Kawasaki"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"},{"@value":"Department of Otolaryngology—Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769997463","@type":"Researcher","foaf:name":[{"@value":"Keita Kai"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Saga University Hospital, Saga 849-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769997574","@type":"Researcher","foaf:name":[{"@value":"Akimichi Minesaki"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology—Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769997464","@type":"Researcher","foaf:name":[{"@value":"Sachiko Maeda"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769997442","@type":"Researcher","foaf:name":[{"@value":"Moriyasu Yamauchi"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology—Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021390769997448","@type":"Researcher","foaf:name":[{"@value":"Yuichiro Kuratomi"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology—Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2024-02-08","prism:volume":"25","prism:number":"4","prism:startingPage":"2093"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/25/4/2093/pdf"}],"createdAt":"2024-02-09","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040854882534686464","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K16913"},{"@type":"JGN","@value":"JP22K16913"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K16913/"}],"notation":[{"@language":"ja","@value":"喉頭癌組織における樹状細胞の役割と臨床的意義の解明"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142849281024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction 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