{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021391867079040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/nu16040476"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6643/16/4/476/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Early enteral nutrition using reliable biomarkers of intestinal function must be established to improve neurodevelopmental outcomes in very low birth weight infants (VLBWIs). Serum citrulline levels reflect the intestinal function in adults. To elucidate the relationship among antenatal growth, postnatal enteral nutrition, and blood citrulline levels, a retrospective single-center observational study was conducted on 248 VLBWIs born between April 2014 and March 2021. A mixed effect model and post hoc simple slope analysis were used to estimate the correlations between clinical variables and citrulline levels at Early (day 5.1) and Late (day 24.3) postnatal ages. Greater gestational age, birth weight, and amount of enteral nutrition at the time of blood sampling were associated with lower citrulline levels at the Early postnatal age and higher citrulline levels at the Late postnatal age. Provided that Early citrulline levels predominantly reflect the consequence of antenatal citrulline metabolism, it is suggested that fetal growth and maturation are likely to promote citrulline catabolism in utero and its synthesis after birth. With additional insights into the temporal transition point wherein the maturation-dependent balance of citrulline metabolism shifts from catabolism-dominant to synthesis-dominant, citrulline emerges as a potential biomarker for assessing intestinal function and gastrointestinal disorders.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021391867079174","@type":"Researcher","foaf:name":[{"@value":"Midori Obayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079040","@type":"Researcher","foaf:name":[{"@value":"Sachiko Iwata"}],"jpcoar:affiliationName":[{"@value":"Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079044","@type":"Researcher","foaf:name":[{"@value":"Tomoya Okuda"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079058","@type":"Researcher","foaf:name":[{"@value":"Ichita Mori"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079063","@type":"Researcher","foaf:name":[{"@value":"Shigeharu Nakane"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079180","@type":"Researcher","foaf:name":[{"@value":"Yasuko Togawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079177","@type":"Researcher","foaf:name":[{"@value":"Mari Sugimoto"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079173","@type":"Researcher","foaf:name":[{"@value":"Takao Togawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"},{"@value":"Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079046","@type":"Researcher","foaf:name":[{"@value":"Kanji Muramatsu"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079181","@type":"Researcher","foaf:name":[{"@value":"Shinji Saitoh"}],"jpcoar:affiliationName":[{"@value":"Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079168","@type":"Researcher","foaf:name":[{"@value":"Takahiro Sugiura"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391867079175","@type":"Researcher","foaf:name":[{"@value":"Osuke Iwata"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neonatology, Toyohashi Municipal Hospital, 50 Aza Hakken Nishi, Aotake-cho, Toyohashi 441-8570, Japan"},{"@value":"Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20726643"}],"prism:publicationName":[{"@value":"Nutrients"}],"dc:publisher":[{"@value":"MDPI 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