{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021391875839744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/sciadv.ade2780"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/sciadv.ade2780"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            An East Asian–specific variant on\n            <jats:italic>aldehyde dehydrogenase 2</jats:italic>\n            (\n            <jats:italic>ALDH2</jats:italic>\n            rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (\n            <jats:italic>GCKR</jats:italic>\n            ,\n            <jats:italic>KLB</jats:italic>\n            , and\n            <jats:italic>ADH1B</jats:italic>\n            ) in wild-type homozygotes and six (\n            <jats:italic>GCKR</jats:italic>\n            ,\n            <jats:italic>ADH1B</jats:italic>\n            ,\n            <jats:italic>ALDH1B1</jats:italic>\n            ,\n            <jats:italic>ALDH1A1</jats:italic>\n            ,\n            <jats:italic>ALDH2</jats:italic>\n            , and\n            <jats:italic>GOT2</jats:italic>\n            ) in heterozygotes, with five showing genome-wide significant interaction with rs671. Genetic correlation analyses revealed ancestry-specific genetic architecture in heterozygotes. Of the discovered loci, four (\n            <jats:italic>GCKR</jats:italic>\n            ,\n            <jats:italic>ADH1B</jats:italic>\n            ,\n            <jats:italic>ALDH1A1</jats:italic>\n            , and\n            <jats:italic>ALDH2</jats:italic>\n            ) were suggested to interact with rs671 in the risk of esophageal cancer, a representative alcohol-related disease. Our results identify the genotype-specific genetic architecture of alcohol consumption and reveal its potential impact on alcohol-related disease risk.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021391875839889","@type":"Researcher","foaf:name":[{"@value":"Yuriko N. Koyanagi"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839886","@type":"Researcher","foaf:name":[{"@value":"Masahiro Nakatochi"}],"jpcoar:affiliationName":[{"@value":"Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839893","@type":"Researcher","foaf:name":[{"@value":"Shinichi Namba"}],"jpcoar:affiliationName":[{"@value":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839882","@type":"Researcher","foaf:name":[{"@value":"Isao Oze"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839890","@type":"Researcher","foaf:name":[{"@value":"Hadrien Charvat"}],"jpcoar:affiliationName":[{"@value":"Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan."},{"@value":"Division of International Health Policy Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan."},{"@value":"Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839755","@type":"Researcher","foaf:name":[{"@value":"Akira Narita"}],"jpcoar:affiliationName":[{"@value":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839748","@type":"Researcher","foaf:name":[{"@value":"Takahisa Kawaguchi"}],"jpcoar:affiliationName":[{"@value":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840000","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Ikezaki"}],"jpcoar:affiliationName":[{"@value":"Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan."},{"@value":"Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839902","@type":"Researcher","foaf:name":[{"@value":"Asahi Hishida"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839900","@type":"Researcher","foaf:name":[{"@value":"Megumi Hara"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840004","@type":"Researcher","foaf:name":[{"@value":"Toshiro Takezaki"}],"jpcoar:affiliationName":[{"@value":"Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839757","@type":"Researcher","foaf:name":[{"@value":"Teruhide Koyama"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839750","@type":"Researcher","foaf:name":[{"@value":"Yohko Nakamura"}],"jpcoar:affiliationName":[{"@value":"Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839891","@type":"Researcher","foaf:name":[{"@value":"Sadao Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839896","@type":"Researcher","foaf:name":[{"@value":"Sakurako Katsuura-Kamano"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840003","@type":"Researcher","foaf:name":[{"@value":"Kiyonori Kuriki"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839885","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Nakamura"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health, Shiga University of Medical Science, Otsu, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839874","@type":"Researcher","foaf:name":[{"@value":"Kenji Takeuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan."},{"@value":"Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan."},{"@value":"Division for Regional Community Development, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839884","@type":"Researcher","foaf:name":[{"@value":"Atsushi Hozawa"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839876","@type":"Researcher","foaf:name":[{"@value":"Kengo Kinoshita"}],"jpcoar:affiliationName":[{"@value":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840005","@type":"Researcher","foaf:name":[{"@value":"Yoichi Sutoh"}],"jpcoar:affiliationName":[{"@value":"Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839758","@type":"Researcher","foaf:name":[{"@value":"Kozo Tanno"}],"jpcoar:affiliationName":[{"@value":"Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan."},{"@value":"Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839751","@type":"Researcher","foaf:name":[{"@value":"Atsushi Shimizu"}],"jpcoar:affiliationName":[{"@value":"Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan."},{"@value":"Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839753","@type":"Researcher","foaf:name":[{"@value":"Hidemi Ito"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."},{"@value":"Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840006","@type":"Researcher","foaf:name":[{"@value":"Yumiko Kasugai"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."},{"@value":"Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839881","@type":"Researcher","foaf:name":[{"@value":"Yukino Kawakatsu"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839747","@type":"Researcher","foaf:name":[{"@value":"Yukari Taniyama"}],"jpcoar:affiliationName":[{"@value":"Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839756","@type":"Researcher","foaf:name":[{"@value":"Masahiro Tajika"}],"jpcoar:affiliationName":[{"@value":"Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840007","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Shimizu"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839754","@type":"Researcher","foaf:name":[{"@value":"Etsuji Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan."},{"@value":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839752","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Hosono"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839872","@type":"Researcher","foaf:name":[{"@value":"Issei Imoto"}],"jpcoar:affiliationName":[{"@value":"Aichi Cancer Center Research Institute, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839898","@type":"Researcher","foaf:name":[{"@value":"Yasuharu Tabara"}],"jpcoar:affiliationName":[{"@value":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."},{"@value":"Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839879","@type":"Researcher","foaf:name":[{"@value":"Meiko Takahashi"}],"jpcoar:affiliationName":[{"@value":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839888","@type":"Researcher","foaf:name":[{"@value":"Kazuya Setoh"}],"jpcoar:affiliationName":[{"@value":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839899","@type":"Researcher","foaf:name":[{"@value":"Koichi Matsuda"}],"jpcoar:affiliationName":[{"@value":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839880","@type":"Researcher","foaf:name":[{"@value":"Shiori Nakano"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839883","@type":"Researcher","foaf:name":[{"@value":"Atsushi Goto"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan."},{"@value":"Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839744","@type":"Researcher","foaf:name":[{"@value":"Ryoko Katagiri"}],"jpcoar:affiliationName":[{"@value":"Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan."},{"@value":"National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840001","@type":"Researcher","foaf:name":[{"@value":"Taiki Yamaji"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839894","@type":"Researcher","foaf:name":[{"@value":"Norie Sawada"}],"jpcoar:affiliationName":[{"@value":"Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839875","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Tsugane"}],"jpcoar:affiliationName":[{"@value":"Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan."},{"@value":"National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839746","@type":"Researcher","foaf:name":[{"@value":"Kenji Wakai"}],"jpcoar:affiliationName":[{"@value":"Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839897","@type":"Researcher","foaf:name":[{"@value":"Masayuki Yamamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839887","@type":"Researcher","foaf:name":[{"@value":"Makoto Sasaki"}],"jpcoar:affiliationName":[{"@value":"Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan."},{"@value":"Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839878","@type":"Researcher","foaf:name":[{"@value":"Fumihiko Matsuda"}],"jpcoar:affiliationName":[{"@value":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875840002","@type":"Researcher","foaf:name":[{"@value":"Yukinori Okada"}],"jpcoar:affiliationName":[{"@value":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan."},{"@value":"Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."},{"@value":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan."},{"@value":"Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan."},{"@value":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391875839745","@type":"Researcher","foaf:name":[{"@value":"Motoki Iwasaki"}],"jpcoar:affiliationName":[{"@value":"Division of Epidemiology, National Cancer Center 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