{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021391882972928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-023-42342-y"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-023-42342-y.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-023-42342-y"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin ligase complex UBR4-KCMF1 and the acetyltransferase NatC recognize proteins bearing an unacetylated N-terminal methionine followed by a hydrophobic residue. NatC KO-induced protein degradation and phenotypes are reversed by UBR knockdown, demonstrating the central cellular role of this interplay. We reveal that loss of\n                    <jats:italic>Drosophila</jats:italic>\n                    NatC is associated with male sterility, reduced longevity, and age-dependent loss of motility due to developmental muscle defects. Remarkably, muscle-specific overexpression of UbcE2M, one of the proteins targeted for NatC KO-mediated degradation, suppresses defects of NatC deletion. In conclusion, NatC-mediated N-terminal acetylation acts as a protective mechanism against protein degradation, which is relevant for increased longevity and motility.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021391882972824","@type":"Researcher","foaf:name":[{"@value":"Sylvia Varland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972674","@type":"Researcher","foaf:name":[{"@value":"Rui Duarte Silva"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972818","@type":"Researcher","foaf:name":[{"@value":"Ine Kjosås"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972827","@type":"Researcher","foaf:name":[{"@value":"Alexandra Faustino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972566","@type":"Researcher","foaf:name":[{"@value":"Annelies Bogaert"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972837","@type":"Researcher","foaf:name":[{"@value":"Maximilian Billmann"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972831","@type":"Researcher","foaf:name":[{"@value":"Hadi Boukhatmi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972556","@type":"Researcher","foaf:name":[{"@value":"Barbara Kellen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972832","@type":"Researcher","foaf:name":[{"@value":"Michael Costanzo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972804","@type":"Researcher","foaf:name":[{"@value":"Adrian Drazic"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972554","@type":"Researcher","foaf:name":[{"@value":"Camilla Osberg"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972575","@type":"Researcher","foaf:name":[{"@value":"Katherine Chan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972928","@type":"Researcher","foaf:name":[{"@value":"Xiang Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972835","@type":"Researcher","foaf:name":[{"@value":"Amy Hin Yan Tong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972546","@type":"Researcher","foaf:name":[{"@value":"Simonetta Andreazza"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972936","@type":"Researcher","foaf:name":[{"@value":"Juliette J. 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Myers"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972815","@type":"Researcher","foaf:name":[{"@value":"Kris Gevaert"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751165342336","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70601342"},{"@type":"NRID","@value":"1000070601342"},{"@type":"NRID","@value":"9000411077226"}],"foaf:name":[{"@value":"Charles Boone"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972676","@type":"Researcher","foaf:name":[{"@value":"Rui Gonçalo Martinho"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021391882972820","@type":"Researcher","foaf:name":[{"@value":"Thomas Arnesen"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media 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