{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021393776054272.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41559-022-01784-1"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41559-022-01784-1.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41559-022-01784-1"}}],"dc:title":[{"@value":"A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Ant colonies with permanent division of labour between castes and highly distinct roles of the sexes have been conceptualized to be superorganisms, but the cellular and molecular mechanisms that mediate caste/sex-specific behavioural specialization have remained obscure. Here we characterized the brain cell repertoire of queens, gynes (virgin queens), workers and males of<jats:italic>Monomorium pharaonis</jats:italic>by obtaining 206,367 single-nucleus transcriptomes. In contrast to<jats:italic>Drosophila</jats:italic>, the mushroom body Kenyon cells are abundant in ants and display a high diversity with most subtypes being enriched in worker brains, the evolutionarily derived caste. Male brains are as specialized as worker brains but with opposite trends in cell composition with higher abundances of all optic lobe neuronal subtypes, while the composition of gyne and queen brains remained generalized, reminiscent of solitary ancestors. Role differentiation from virgin gynes to inseminated queens induces abundance changes in roughly 35% of cell types, indicating active neurogenesis and/or programmed cell death during this transition. We also identified insemination-induced cell changes probably associated with the longevity and fecundity of the reproductive caste, including increases of ensheathing glia and a population of dopamine-regulated<jats:italic>Dh31</jats:italic>-expressing neurons. We conclude that permanent caste differentiation and extreme sex-differentiation induced major changes in the neural circuitry of ants.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021393776054298","@type":"Researcher","foaf:name":[{"@value":"Qiye Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054289","@type":"Researcher","foaf:name":[{"@value":"Mingyue Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054295","@type":"Researcher","foaf:name":[{"@value":"Pei Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054274","@type":"Researcher","foaf:name":[{"@value":"Yang Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054285","@type":"Researcher","foaf:name":[{"@value":"Qunfei Guo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054290","@type":"Researcher","foaf:name":[{"@value":"Yuanzhen Zhu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054272","@type":"Researcher","foaf:name":[{"@value":"Tinggang Wen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054299","@type":"Researcher","foaf:name":[{"@value":"Xueqin Dai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054279","@type":"Researcher","foaf:name":[{"@value":"Xiafang Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054283","@type":"Researcher","foaf:name":[{"@value":"Manuel Nagel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054278","@type":"Researcher","foaf:name":[{"@value":"Bjarke Hamberg Dethlefsen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054280","@type":"Researcher","foaf:name":[{"@value":"Nianxia Xie"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054300","@type":"Researcher","foaf:name":[{"@value":"Jie Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054284","@type":"Researcher","foaf:name":[{"@value":"Wei Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054286","@type":"Researcher","foaf:name":[{"@value":"Lei Han"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054287","@type":"Researcher","foaf:name":[{"@value":"Liang Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054282","@type":"Researcher","foaf:name":[{"@value":"Wenjiang Zhong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054281","@type":"Researcher","foaf:name":[{"@value":"Zhifeng Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054291","@type":"Researcher","foaf:name":[{"@value":"Xiaoyu Wei"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054297","@type":"Researcher","foaf:name":[{"@value":"Wei Dai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054294","@type":"Researcher","foaf:name":[{"@value":"Longqi Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054277","@type":"Researcher","foaf:name":[{"@value":"Xun Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054296","@type":"Researcher","foaf:name":[{"@value":"Haorong Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054273","@type":"Researcher","foaf:name":[{"@value":"Huanming Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054288","@type":"Researcher","foaf:name":[{"@value":"Jian Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054292","@type":"Researcher","foaf:name":[{"@value":"Jacobus J. Boomsma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054293","@type":"Researcher","foaf:name":[{"@value":"Chuanyu Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054276","@type":"Researcher","foaf:name":[{"@value":"Guojie Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393776054275","@type":"Researcher","foaf:name":[{"@value":"Weiwei Liu"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2397334X"}],"prism:publicationName":[{"@value":"Nature Ecology & Evolution"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2022-06-16","prism:volume":"6","prism:number":"8","prism:startingPage":"1191","prism:endingPage":"1204"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41559-022-01784-1.pdf"},{"@id":"https://www.nature.com/articles/s41559-022-01784-1"}],"createdAt":"2022-06-16","modifiedAt":"2024-09-27","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302866862300928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible functions of ecdysone signaling reiteratively used in the adult honey bee brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815696094976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1390865519340652544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hymenopteran insects as model lineages for the study of brain basis related to the behavioral evolution."},{"@language":"ja","@value":"行動進化に関わる脳基盤研究のモデル系統としてのハチ目昆虫"},{"@language":"ja-Kana","@value":"コウドウ シンカ ニ カカワル ノウ キバン ケンキュウ ノ モデル ケイトウ ト シテ ノ ハチモク コンチュウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41559-022-01784-1"},{"@type":"CROSSREF","@value":"10.3330/hikakuseiriseika.41.131_references_DOI_PTkRSsv92WifTcbkq855b157EqK"},{"@type":"CROSSREF","@value":"10.3389/frbee.2023.1251714_references_DOI_PTkRSsv92WifTcbkq855b157EqK"},{"@type":"CROSSREF","@value":"10.1038/s41598-023-37001-7_references_DOI_PTkRSsv92WifTcbkq855b157EqK"}]}