{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021393793965696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.apsb.2021.05.027"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211383521002069?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211383521002069?httpAccept=text/plain"}}],"dc:title":[{"@value":"Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021393793965701","@type":"Researcher","foaf:name":[{"@value":"Xiangjin Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965702","@type":"Researcher","foaf:name":[{"@value":"Wan Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965703","@type":"Researcher","foaf:name":[{"@value":"Huanli Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965696","@type":"Researcher","foaf:name":[{"@value":"Jinyi Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965705","@type":"Researcher","foaf:name":[{"@value":"Liwen Ren"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965704","@type":"Researcher","foaf:name":[{"@value":"Yihui Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965699","@type":"Researcher","foaf:name":[{"@value":"Sha Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965697","@type":"Researcher","foaf:name":[{"@value":"Jinhua Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965698","@type":"Researcher","foaf:name":[{"@value":"Tengfei Ji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021393793965700","@type":"Researcher","foaf:name":[{"@value":"Guanhua Du"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"22113835"}],"prism:publicationName":[{"@value":"Acta Pharmaceutica Sinica B"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2021-11","prism:volume":"11","prism:number":"11","prism:startingPage":"3465","prism:endingPage":"3480"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2211383521002069?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2211383521002069?httpAccept=text/plain"}],"createdAt":"2021-05-27","modifiedAt":"2025-10-31","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360865815498267392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.apsb.2021.05.027"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.3c01090_references_DOI_VeiHlBfgvWdlNZUoLxsc03wo0UJ"}]}