{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360021395967949568.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/advs.202003627"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202003627"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202003627"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202003627"}}],"dc:title":[{"@value":"Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021395967949571","@type":"Researcher","foaf:name":[{"@value":"Zifeng Yang"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949576","@type":"Researcher","foaf:name":[{"@value":"Rongkang Huang"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949573","@type":"Researcher","foaf:name":[{"@value":"Bingna Zheng"}],"jpcoar:affiliationName":[{"@value":"PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University  Guangzhou 510275 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949574","@type":"Researcher","foaf:name":[{"@value":"Wentai Guo"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949578","@type":"Researcher","foaf:name":[{"@value":"Chuangkun Li"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949569","@type":"Researcher","foaf:name":[{"@value":"Wenyi He"}],"jpcoar:affiliationName":[{"@value":"PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University  Guangzhou 510275 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949575","@type":"Researcher","foaf:name":[{"@value":"Yingqi Wei"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949577","@type":"Researcher","foaf:name":[{"@value":"Yang Du"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949572","@type":"Researcher","foaf:name":[{"@value":"Huaiming Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949570","@type":"Researcher","foaf:name":[{"@value":"Dingcai Wu"}],"jpcoar:affiliationName":[{"@value":"PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University  Guangzhou 510275 P. R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380021395967949568","@type":"Researcher","foaf:name":[{"@value":"Hui Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases  Guangzhou 510655 P. R. China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"21983844"},{"@type":"EISSN","@value":"21983844"}],"prism:publicationName":[{"@value":"Advanced Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2021-03-05","prism:volume":"8","prism:number":"8"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202003627"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202003627"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202003627"}],"createdAt":"2021-03-05","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302865730342912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hemostatic patch with ultra-strengthened mechanical properties for efficient adhesion to wet surfaces"}]},{"@id":"https://cir.nii.ac.jp/crid/1390307746601286016","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"炭酸水を用いたアルギン酸ハイドロゲルの創製とサステナブルな創傷被覆材への展開"},{"@language":"en","@value":"Preparation of Alginate Hydrogels Using Carbonated Water and Their Application as Sustainable Wound Dressings"},{"@language":"ja-Kana","@value":"タンサンスイ オ モチイタ アルギンサン ハイドロゲル ノ ソウセイ ト サステナブル ナ ソウショウ ヒフクザイ エ ノ テンカイ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/advs.202003627"},{"@type":"CROSSREF","@value":"10.1016/j.biomaterials.2023.122240_references_DOI_RBDD81OnhWRduiE0u30eGPTAvk0"},{"@type":"CROSSREF","@value":"10.4011/shikizai.99.65_references_DOI_RBDD81OnhWRduiE0u30eGPTAvk0"}]}