{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360022497415518336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/23969873221148267"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/23969873221148267"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1177/23969873221148267"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/esj/article-pdf/8/1/344/64655102/23969873221148267.pdf"}}],"dc:title":[{"@value":"Age of onset of cerebral venous thrombosis: the BEAST study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Background:</jats:title>\n                    <jats:p>Cerebral venous thrombosis (CVT) is an uncommon cause of stroke in young adults. We aimed to determine the impact of age, gender and risk factors (including sex-specific) on CVT onset.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>We used data from the BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis), a multicentre multinational prospective observational study on CVT. Composite factors analysis (CFA) was performed to determine the impact on the age of CVT onset in males and females.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>A total of 1309 CVT patients (75.3% females) aged ⩾18 years were recruited. The overall median (IQR-interquartile range) age for males and females was 46 (35–58) years and 37 (28–47) years (p &lt; 0.001), respectively. However, the presence of antibiotic-requiring sepsis (p = 0.03, 95% CI 27–47 years) among males and gender-specific risk factors like pregnancy (p &lt; 0.001, 95% CI 29–34 years), puerperium (p &lt; 0.001, 95% CI 26–34 years) and oral contraceptive use (p &lt; 0.001, 95% CI 33–36 years) were significantly associated with earlier onset of CVT among females. CFA demonstrated a significantly earlier onset of CVT in females, ~12 years younger, in those with multiple (⩾1) compared to ‘0’ risk factors (p &lt; 0.001, 95% CI 32–35 years).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>Women suffer CVT 9 years earlier in comparison to men. Female patients with multiple (⩾1) risk factors suffer CVT ~12 years earlier compared to those with no identifiable risk factors.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380022497415518340","@type":"Researcher","foaf:name":[{"@value":"Redoy Ranjan"}],"jpcoar:affiliationName":[{"@value":"Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518363","@type":"Researcher","foaf:name":[{"@value":"Gie Ken-Dror"}],"jpcoar:affiliationName":[{"@value":"Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518337","@type":"Researcher","foaf:name":[{"@value":"Ida Martinelli"}],"jpcoar:affiliationName":[{"@value":"Fondazione IRCCS Ca’Granda – Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518350","@type":"Researcher","foaf:name":[{"@value":"Elvira Grandone"}],"jpcoar:affiliationName":[{"@value":"Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy 3"},{"@value":"Medical and Surgical Department, University of Foggia, Foggia, Italy 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518345","@type":"Researcher","foaf:name":[{"@value":"Sini Hiltunen"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 5"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518355","@type":"Researcher","foaf:name":[{"@value":"Erik Lindgren"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden 6"},{"@value":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden 7"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518353","@type":"Researcher","foaf:name":[{"@value":"Maurizio Margaglione"}],"jpcoar:affiliationName":[{"@value":"Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy 8"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518368","@type":"Researcher","foaf:name":[{"@value":"Veronique Le Cam Duchez"}],"jpcoar:affiliationName":[{"@value":"Normandy University, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit and INSERM CIC-CRB 1404, Rouen, France 9"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518349","@type":"Researcher","foaf:name":[{"@value":"Aude Bagan Triquenot"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Rouen University Hospital, Rouen, France 10"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518352","@type":"Researcher","foaf:name":[{"@value":"Marialuisa Zedde"}],"jpcoar:affiliationName":[{"@value":"Neurology Unit, Stroke Unit, Local Health Unit – Authority IRCCS of Reggio Emilia, Reggio Emilia, Italy 11"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518212","@type":"Researcher","foaf:name":[{"@value":"Michelangelo Mancuso"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy 12"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518369","@type":"Researcher","foaf:name":[{"@value":"Ynte M Ruigrok"}],"jpcoar:affiliationName":[{"@value":"UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands 13"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518370","@type":"Researcher","foaf:name":[{"@value":"Brad Worrall"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Virginia, Charlottesville, VA, USA 14"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518351","@type":"Researcher","foaf:name":[{"@value":"Jennifer J Majersik"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Utah, Salt Lake City, UT, USA 15"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518359","@type":"Researcher","foaf:name":[{"@value":"Jukka Putaala"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 5"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518372","@type":"Researcher","foaf:name":[{"@value":"Elena Haapaniemi"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 5"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518338","@type":"Researcher","foaf:name":[{"@value":"Susanna M Zuurbier"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands 16"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518366","@type":"Researcher","foaf:name":[{"@value":"Matthijs C Brouwer"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands 16"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518371","@type":"Researcher","foaf:name":[{"@value":"Serena M Passamonti"}],"jpcoar:affiliationName":[{"@value":"Fondazione IRCCS Ca’Granda – Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518365","@type":"Researcher","foaf:name":[{"@value":"Maria Abbattista"}],"jpcoar:affiliationName":[{"@value":"Fondazione IRCCS Ca’Granda – Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518209","@type":"Researcher","foaf:name":[{"@value":"Paolo Bucciarelli"}],"jpcoar:affiliationName":[{"@value":"Fondazione IRCCS Ca’Granda – Ospedale Maggiore Policlinico, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518356","@type":"Researcher","foaf:name":[{"@value":"Robin Lemmens"}],"jpcoar:affiliationName":[{"@value":"Department of Neurosciences, Experimental Neurology, KU Leuven–University of Leuven, Leuven, Belgium 17"},{"@value":"VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, Leuven, Belgium 18"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518346","@type":"Researcher","foaf:name":[{"@value":"Emanuela Pappalardo"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy 19"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518362","@type":"Researcher","foaf:name":[{"@value":"Paolo Costa"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy 20"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518208","@type":"Researcher","foaf:name":[{"@value":"Marina Colombi"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy 21"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518348","@type":"Researcher","foaf:name":[{"@value":"Diana Aguiar de Sousa"}],"jpcoar:affiliationName":[{"@value":"Stroke Center, Lisbon Central University Hospital, Lisbon, Portugal 22"},{"@value":"CEEM and Institute of Anatomy, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal 23"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518357","@type":"Researcher","foaf:name":[{"@value":"Sofia Rodrigues"}],"jpcoar:affiliationName":[{"@value":"Department of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal 24"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518358","@type":"Researcher","foaf:name":[{"@value":"Patrícia Canhao"}],"jpcoar:affiliationName":[{"@value":"Department of Neurosciences, Hospital of Santa Maria, University of Lisbon, Lisbon, Portugal 24"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518210","@type":"Researcher","foaf:name":[{"@value":"Aleksander Tkach"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Utah, Salt Lake City, UT, USA 15"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518339","@type":"Researcher","foaf:name":[{"@value":"Rosa Santacroce"}],"jpcoar:affiliationName":[{"@value":"Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy 8"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518367","@type":"Researcher","foaf:name":[{"@value":"Giovanni Favuzzi"}],"jpcoar:affiliationName":[{"@value":"Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy 3"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518343","@type":"Researcher","foaf:name":[{"@value":"Antonio Arauz"}],"jpcoar:affiliationName":[{"@value":"Stroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico 25"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518361","@type":"Researcher","foaf:name":[{"@value":"Donatella Colaizzo"}],"jpcoar:affiliationName":[{"@value":"Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Home for the Relief of Suffering, S. Giovanni Rotondo, Foggia, Italy 3"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518341","@type":"Researcher","foaf:name":[{"@value":"Kostas Spengos"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece 26"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518211","@type":"Researcher","foaf:name":[{"@value":"Amanda Hodge"}],"jpcoar:affiliationName":[{"@value":"McMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada 27"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518336","@type":"Researcher","foaf:name":[{"@value":"Reina Ditta"}],"jpcoar:affiliationName":[{"@value":"McMaster University, Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada 27"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518364","@type":"Researcher","foaf:name":[{"@value":"Thang S Han"}],"jpcoar:affiliationName":[{"@value":"Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK 1"},{"@value":"Department of Diabetes and Endocrinology, Ashford and St Peter’s NHS Foundation Trust, Chertsey, UK 28"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518213","@type":"Researcher","foaf:name":[{"@value":"Alessandro Pezzini"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy 20"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518344","@type":"Researcher","foaf:name":[{"@value":"Jonathan M Coutinho"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Amsterdam University Medical Centers, Location AMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands 16"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518373","@type":"Researcher","foaf:name":[{"@value":"Vincent Thijs"}],"jpcoar:affiliationName":[{"@value":"Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia 29"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518354","@type":"Researcher","foaf:name":[{"@value":"Katarina Jood"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden 6"},{"@value":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden 7"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518342","@type":"Researcher","foaf:name":[{"@value":"Turgut Tatlisumak"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 5"},{"@value":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden 6"},{"@value":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden 7"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518347","@type":"Researcher","foaf:name":[{"@value":"José M Ferro"}],"jpcoar:affiliationName":[{"@value":"Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal 30"}]},{"@id":"https://cir.nii.ac.jp/crid/1380022497415518360","@type":"Researcher","foaf:name":[{"@value":"Pankaj Sharma"}],"jpcoar:affiliationName":[{"@value":"Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK 1"},{"@value":"Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK 31"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23969873"},{"@type":"EISSN","@value":"23969881"}],"prism:publicationName":[{"@value":"European Stroke Journal"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2023-03-01","prism:volume":"8","prism:number":"1","prism:startingPage":"344","prism:endingPage":"350"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights","https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/23969873221148267"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1177/23969873221148267"},{"@id":"https://academic.oup.com/esj/article-pdf/8/1/344/64655102/23969873221148267.pdf"}],"createdAt":"2023-01-07","modifiedAt":"2026-01-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390867996486794240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Profile of Cerebral Sinus Venous Thrombosis:  A Prospective Observational Study in South India"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/23969873221148267"},{"@type":"CROSSREF","@value":"10.2739/kurumemedj.ms7112012_references_DOI_Fh3Qd318R9nraZDVAOSXQkKzYqw"}]}